SUMO2 蛋白, Human (His)

Small ubiquitin-related modifier 2 (SUMO2) is a ubiquitin-like protein that covalently attached to proteins as part of post-translational modification system. SUMO2 is involved in a variety of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, DNA replication and repair, mitosis, signal transduction and protein stability. SUMO2 Protein, Human (His) is the recombinant human-derived SUMO2 protein, expressed by E. coli , with N-6*His labeled tag. The total length of SUMO2 Protein, Human (His) is 93 a.a., with molecular weight of ~17.0 kDa.

小泛素相关修饰因子 2 (SUMO2) 是 SUMO 蛋白家族的成员。SUMO2 是一种泛素样蛋白，可以作为单体或赖氨酸连接的聚合物共价附着在蛋白质上，是翻译后修饰系统的一部分。SUMO2 参与多种细胞过程，如核转运、转录调控、凋亡、DNA 复制和修复、有丝分裂、信号转导和蛋白质稳定性等。直到羧基末端的最后两个氨基酸被切割掉，SUMO2 才有活性。聚合 SUMO2 链也易受多泛素化的影响，多泛素化是蛋白酶体降解被修饰蛋白的信号。SUMO2 也在调节 SETX 的苏酰化状态中发挥作用。

Human

E. coli

N-6*His

AAH08450.1 (M1-G93)

6613  [NCBI]

MADEKPKEGVKTENNNHINLKVAGQDGSVVQFKIKRHTPLSKLMKAYCERQGLSMRQIRFRFDGQPINETDTPAQLEMEDEDTIDVFQQQTGG

Approximately 17.0 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US;may vary elsewhere.