1. Gene
  2. RAD23A - RAD23 homolog A, nucleotide excision repair protein Gene

RAD23A - RAD23 homolog A, nucleotide excision repair protein Gene

中文名称:RAD23 同系物 A,核苷酸切除修复蛋白

种属: Homo sapiens

同用名: HR23A; HHR23A

基因 ID: 5886 | 基因类型: protein coding

关于 RAD23A

Cytogenetic location: 19p13.13 Genomic coordinates (GRCh38): 19:12,945,862-12,953,642 (from NCBI)

This gene has 11 transcripts (splice variants), 198 orthologues and 1 paralogue. Ubiquitous expression in fat (RPKM 50.3), heart (RPKM 47.4) and 25 other tissues.

功能概要

由该基因编码的蛋白质是酿酒酵母 Rad23 的两个人类同系物之一,这是一种参与核苷酸切除修复的蛋白质。该家族中的蛋白质具有模块化结构域结构,由泛素样结构域 (UbL) 、泛素相关结构域 1 (UbA1) 、XPC 结合结构域和 UbA2 组成。由该基因编码的蛋白质在核苷酸切除修复以及将多泛素化蛋白质递送至蛋白酶体中起着重要作用。可变剪接导致编码多个亚型的多个转录本变体。[RefSeq 提供,2012 年 6 月]

The protein encoded by this gene is one of two human homologs of Saccharomyces cerevisiae Rad23, a protein involved in nucleotide excision repair. Proteins in this family have a modular domain structure consisting of an ubiquitin-like domain (UbL), ubiquitin-associated domain 1 (UbA1), XPC-binding domain and UbA2. The protein encoded by this gene plays an important role in nucleotide excision repair and also in delivery of polyubiquitinated proteins to the Proteasome. Alternative splicing results in multiple transcript variants encoding multiple isoforms. [provided by RefSeq, Jun 2012]

RAD23A 基因产物(3)

mRNA Protein Name
NM_001270362.2 NP_001257291.1 UV excision repair protein RAD23 homolog A isoform 2
NM_001270363.2 NP_001257292.1 UV excision repair protein RAD23 homolog A isoform 3
NM_005053.4 NP_005044.1 UV excision repair protein RAD23 homolog A isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables kinase binding IPI
IPI: 通过物理相互作用推断
26296656 GOA
enables polyubiquitin modification-dependent protein binding IDA
IDA: 通过直接分析推断
12643283 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
10488153 GOA
enables ubiquitin-specific protease binding IPI
IPI: 通过物理相互作用推断
22970133 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in nucleotide-excision repair IDA
IDA: 通过直接分析推断
9372924 GOA
involved in positive regulation of cell cycle IMP
IMP: 通过突变表型推断
26296656 GOA
involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
IMP: 通过突变表型推断
26296656 GOA
involved in positive regulation of viral genome replication IMP
IMP: 通过突变表型推断
20614012 GOA
involved in protein destabilization IMP
IMP: 通过突变表型推断
26296656 GOA
involved in regulation of proteasomal ubiquitin-dependent protein catabolic process IDA
IDA: 通过直接分析推断
12643283 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
26296656 GOA
located in nucleus IDA
IDA: 通过直接分析推断
26296656 GOA
part of protein-containing complex IMP
IMP: 通过突变表型推断
26296656 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

RAD23A 蛋白结构

ubiquitin

ubiquitin: Ubiquitin family (8 - 79)

UBA

UBA: UBA/TS-N domain (163 - 198)

XPC-binding

XPC-binding: XPC-binding domain (232 - 288)

UBA

UBA: UBA/TS-N domain (321 - 355)

  • 0
  • 100
  • 200
  • 300
  • 363 a.a.
蛋白主名 其他名称

UV excision repair protein RAD23 homolog A

RAD23, yeast homolog, A

RAD23A 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra RAD23A P54725 KRTAP12-2 Homo sapiens P59991
Y2H Array
32296183
Intra RAD23A P54725 KRTAP12-2 Homo sapiens P59991
Y2H Prey Pooling
32296183
Intra RAD23A P54725 KRTAP12-2 Homo sapiens P59991
Validated Y2H
32296183
Intra RAD23A P54725 FAM22F Homo sapiens B7ZLH0
Y2H Array
32296183
Intra RAD23A P54725 FAM22F Homo sapiens B7ZLH0
Y2H Prey Pooling
32296183
Intra RAD23A P54725 REL Homo sapiens Q04864-2
Validated Y2H
32296183
Intra RAD23A P54725 REL Homo sapiens Q04864-2
Y2H Array
32296183
Intra RAD23A P54725 REL Homo sapiens Q04864-2
Y2H Prey Pooling
32296183
Intra RAD23A P54725 TRIM55 Homo sapiens Q9BYV6-2
Y2H Prey Pooling
32296183
Intra RAD23A P54725 TRIM55 Homo sapiens Q9BYV6-2
Validated Y2H
32296183
Intra RAD23A P54725 TRIM55 Homo sapiens Q9BYV6-2
Y2H Array
32296183
Intra RAD23A P54725 TRIM39 Homo sapiens Q9HCM9-2
Y2H Array
32296183
Intra RAD23A P54725 TRIM39 Homo sapiens Q9HCM9-2
Y2H Prey Pooling
32296183
Intra RAD23A P54725 TRIM39 Homo sapiens Q9HCM9-2
Validated Y2H
32296183
Intra RAD23A P54725 UBXN1 Homo sapiens Q04323-2
Y2H Prey Pooling
32296183
Intra RAD23A P54725 UBXN1 Homo sapiens Q04323-2
Validated Y2H
32296183
Intra RAD23A P54725 UBXN1 Homo sapiens Q04323-2
Y2H Array
32296183
Intra RAD23A P54725 ATXN3 Homo sapiens Q4VBR4
Y2H Array
32814053
Intra RAD23A P54725 ATXN3 Homo sapiens Q4VBR4
Validated Y2H
32814053
Intra RAD23A P54725 ATXN3 Homo sapiens Q4VBR4
Y2H Array
32296183
Intra RAD23A P54725 ATXN3 Homo sapiens Q4VBR4
Y2H Pooling
32814053
Intra RAD23A P54725 ATXN3 Homo sapiens Q4VBR4
Validated Y2H
32296183
Intra RAD23A P54725 ATXN3 Homo sapiens Q4VBR4
Y2H Prey Pooling
32296183
Intra RAD23A P54725 RABGEF1 Homo sapiens Q9UJ41-4
Y2H Prey Pooling
32296183
Intra RAD23A P54725 RABGEF1 Homo sapiens Q9UJ41-4
Y2H Array
32296183
Intra RAD23A P54725 RABGEF1 Homo sapiens Q9UJ41-4
Validated Y2H
32296183
Intra RAD23A P54725 UIMC1 Homo sapiens Q96RL1-2
Validated Y2H
32296183
Intra RAD23A P54725 UIMC1 Homo sapiens Q96RL1-2
Y2H Prey Pooling
32296183
Intra RAD23A P54725 UIMC1 Homo sapiens Q96RL1-2
Y2H Array
32296183
Intra RAD23A P54725 RNF41 Homo sapiens Q9H4P4
Validated Y2H
32296183
Intra RAD23A P54725 RNF41 Homo sapiens Q9H4P4
Y2H Array
32296183
Intra RAD23A P54725 RNF41 Homo sapiens Q9H4P4
Y2H Prey Pooling
32296183
Intra RAD23A P54725 TRIM54 Homo sapiens Q9BYV2
Y2H Array
25416956
Intra RAD23A P54725 TRIM54 Homo sapiens Q9BYV2
Y2H Prey Pooling
25416956
Intra RAD23A P54725 TRIM8 Homo sapiens Q9BZR9
Validated Y2H
32296183
Intra RAD23A P54725 TRIM8 Homo sapiens Q9BZR9
Y2H Array
32296183
Intra RAD23A P54725 TRIM8 Homo sapiens Q9BZR9
Y2H Prey Pooling
32296183
Intra RAD23A P54725 USP25 Homo sapiens Q9UHP3
Validated Y2H
32296183
Intra RAD23A P54725 USP25 Homo sapiens Q9UHP3
Y2H Array
25416956
Intra RAD23A P54725 USP25 Homo sapiens Q9UHP3
Y2H Array
32296183
Intra RAD23A P54725 USP25 Homo sapiens Q9UHP3
Y2H Prey Pooling
25416956
Intra RAD23A P54725 USP25 Homo sapiens Q9UHP3
Validated Y2H
25416956
Intra RAD23A P54725 USP25 Homo sapiens Q9UHP3
Y2H Prey Pooling
32296183
Intra RAD23A P54725 ITGAV Homo sapiens P06756
Validated Y2H
32814053
Intra RAD23A P54725 ITGAV Homo sapiens P06756
Y2H Array
32814053
Intra RAD23A P54725 ITGAV Homo sapiens P06756
Y2H Pooling
32814053
Intra RAD23A P54725 SQSTM1 Homo sapiens Q13501
Pull Down
16189514
Intra RAD23A P54725 SQSTM1 Homo sapiens Q13501
Y2H Pooling
16189514
Intra RAD23A P54725 EEF1A1 Homo sapiens P68104
Pull Down
16712842
Intra RAD23A P54725 TRAF2 Homo sapiens Q12933
Validated Y2H
25416956
Intra RAD23A P54725 TRAF2 Homo sapiens Q12933
Y2H Pooling
16189514
Intra RAD23A P54725 TRAF2 Homo sapiens Q12933
Validated Y2H
32296183
Intra RAD23A P54725 TRAF2 Homo sapiens Q12933
Y2H Array
32296183
Intra RAD23A P54725 TRAF2 Homo sapiens Q12933
Y2H Prey Pooling
25416956
Intra RAD23A P54725 TRAF2 Homo sapiens Q12933
Y2H Prey Pooling
32296183
Intra RAD23A P54725 UBA52 Homo sapiens P62987
Validated Y2H
32296183
Intra RAD23A P54725 UBA52 Homo sapiens P62987
Y2H Prey Pooling
32296183
Intra RAD23A P54725 UBA52 Homo sapiens P62987
Y2H Array
32296183
Intra RAD23A P54725 RPS27A Homo sapiens P62979
Validated Y2H
32296183
Intra RAD23A P54725 RPS27A Homo sapiens P62979
Y2H Array
32296183
Intra RAD23A P54725 RPS27A Homo sapiens P62979
Y2H Prey Pooling
32296183
Intra RAD23A P54725 TRAF3 Homo sapiens Q13114
Validated Y2H
32296183
Intra RAD23A P54725 TRAF3 Homo sapiens Q13114
Y2H Array
32296183
Intra RAD23A P54725 TRAF3 Homo sapiens Q13114
Y2H Prey Pooling
32296183
Intra RAD23A P54725 TRAF6 Homo sapiens Q9Y4K3
Y2H Prey Pooling
32296183
Intra RAD23A P54725 TRAF6 Homo sapiens Q9Y4K3
Validated Y2H
32296183
Intra RAD23A P54725 TRAF6 Homo sapiens Q9Y4K3
Y2H Array
32296183
Intra RAD23A P54725 PSMD4 Homo sapiens P55036
Pull Down
10488153
Intra RAD23A P54725 PSMD4 Homo sapiens P55036
SPR
12970176
Intra RAD23A P54725 PSMD4 Homo sapiens P55036
Y2H Prey Pooling
32296183
Intra RAD23A P54725 PSMD4 Homo sapiens P55036
Validated Y2H
32296183
Intra RAD23A P54725 PSMD4 Homo sapiens P55036
Y2H Array
32296183
Intra RAD23A P54725 PSMD4 Homo sapiens P55036
Y2H
10488153
Intra RAD23A P54725 PSMD4 Homo sapiens P55036
Pull Down
20059542
Intra RAD23A P54725 MKRN1 Homo sapiens Q9UHC7
Validated Y2H
32296183
Intra RAD23A P54725 MKRN1 Homo sapiens Q9UHC7
Y2H Prey Pooling
32296183
Intra RAD23A P54725 MKRN1 Homo sapiens Q9UHC7
Y2H Array
32296183
Intra RAD23A P54725 ZBTB26 Homo sapiens Q9HCK0
Validated Y2H
32296183
Intra RAD23A P54725 ZBTB26 Homo sapiens Q9HCK0
Y2H Prey Pooling
32296183
Intra RAD23A P54725 ZBTB26 Homo sapiens Q9HCK0
Y2H Array
32296183
Intra RAD23A P54725 TRAF5 Homo sapiens O00463
Y2H Array
25416956
Intra RAD23A P54725 TRAF5 Homo sapiens O00463
Validated Y2H
25416956
Intra RAD23A P54725 TNFAIP3 Homo sapiens P21580
Y2H Array
32296183
Intra RAD23A P54725 TNFAIP3 Homo sapiens P21580
Y2H Prey Pooling
32296183
Intra RAD23A P54725 ZBTB44 Homo sapiens Q8NCP5
Y2H Prey Pooling
25416956
Intra RAD23A P54725 ZBTB44 Homo sapiens Q8NCP5
Validated Y2H
25416956
Intra RAD23A P54725 SGCA Homo sapiens Q16586
Y2H Pooling
32814053
Intra RAD23A P54725 SGCA Homo sapiens Q16586
Validated Y2H
32814053
Intra RAD23A P54725 SGCA Homo sapiens Q16586
Y2H Array
32814053
Intra RAD23A P54725 NGLY1 Homo sapiens Q96IV0
Y2H Array
31515488
Intra RAD23A P54725 NGLY1 Homo sapiens Q96IV0
Validated Y2H
25416956
Intra RAD23A P54725 NGLY1 Homo sapiens Q96IV0
Y2H Prey Pooling
32296183
Intra RAD23A P54725 NGLY1 Homo sapiens Q96IV0
Validated Y2H
32296183
Intra RAD23A P54725 NGLY1 Homo sapiens Q96IV0
Y2H Array
25416956
Intra RAD23A P54725 NGLY1 Homo sapiens Q96IV0
Y2H Array
32296183
Intra RAD23A P54725 DAZAP2 Homo sapiens Q15038
Validated Y2H
32296183
Intra RAD23A P54725 DAZAP2 Homo sapiens Q15038
Y2H Array
32296183
Intra RAD23A P54725 DAZAP2 Homo sapiens Q15038
Y2H Prey Pooling
32296183
Intra RAD23A P54725 ZFAND6 Homo sapiens Q6FIF0
Validated Y2H
32296183
Intra RAD23A P54725 ZFAND6 Homo sapiens Q6FIF0
Y2H Array
32296183
Intra RAD23A P54725 ZFAND6 Homo sapiens Q6FIF0
Y2H Prey Pooling
32296183
Intra RAD23A P54725 MINDY3 Homo sapiens Q9H8M7
Y2H Array
31515488
Intra RAD23A P54725 MINDY3 Homo sapiens Q9H8M7
Validated Y2H
25416956
Intra RAD23A P54725 MINDY3 Homo sapiens Q9H8M7
Y2H Prey Pooling
25416956
Intra RAD23A P54725 MINDY3 Homo sapiens Q9H8M7
Validated Y2H
32296183
Intra RAD23A P54725 MINDY3 Homo sapiens Q9H8M7
Y2H Array
25416956
Intra RAD23A P54725 MINDY3 Homo sapiens Q9H8M7
Y2H Prey Pooling
32296183
Intra RAD23A P54725 MINDY3 Homo sapiens Q9H8M7
Y2H Array
32296183
Intra RAD23A P54725 TRIP6 Homo sapiens Q15654
Validated Y2H
25416956
Intra RAD23A P54725 TRIP6 Homo sapiens Q15654
Y2H Prey Pooling
25416956
Intra RAD23A P54725 ZBTB8A Homo sapiens Q96BR9
Validated Y2H
32296183
Intra RAD23A P54725 ZBTB8A Homo sapiens Q96BR9
Y2H Array
25416956
Intra RAD23A P54725 ZBTB8A Homo sapiens Q96BR9
Y2H Array
32296183
Intra RAD23A P54725 ZBTB8A Homo sapiens Q96BR9
Y2H Prey Pooling
25416956
Intra RAD23A P54725 ZBTB8A Homo sapiens Q96BR9
Y2H Prey Pooling
32296183
Intra RAD23A P54725 CSNK1D Homo sapiens P48730-2
Y2H Pooling
32814053
Intra RAD23A P54725 CSNK1D Homo sapiens P48730-2
Validated Y2H
32814053
Intra RAD23A P54725 CSNK1D Homo sapiens P48730-2
Y2H Array
32814053
Intra RAD23A P54725 UBQLN2 Homo sapiens Q9UHD9
Y2H Array
32296183
Intra RAD23A P54725 UBQLN2 Homo sapiens Q9UHD9
NMR
17098253
Intra RAD23A P54725 UBQLN2 Homo sapiens Q9UHD9
Y2H Prey Pooling
32296183
Intra RAD23A P54725 UBQLN2 Homo sapiens Q9UHD9
Validated Y2H
32296183
Intra RAD23A P54725 CNTROB Homo sapiens Q8N137
Validated Y2H
32296183
Intra RAD23A P54725 CNTROB Homo sapiens Q8N137
Y2H Prey Pooling
32296183
Intra RAD23A P54725 CNTROB Homo sapiens Q8N137
Y2H Array
32296183
Intra RAD23A P54725 TRIM50 Homo sapiens Q86XT4
Y2H Prey Pooling
32296183
Intra RAD23A P54725 TRIM50 Homo sapiens Q86XT4
Validated Y2H
32296183
Intra RAD23A P54725 TRIM50 Homo sapiens Q86XT4
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Xeroderma Pigmentosum, Variant Type

Xeroderma Pigmentosum

XPV

Xeroderma Pigmentosum Variant Type

Xeroderma Pigmentosum With Normal Dna Repair Rates

Photosensitivity With Defective Dna Synthesis

Xp

De Sanctis-Cacchione Syndrome

Desanctis-Cacchione Syndrome

Xeroderma Pigmentosa

Xerodermic Idiocy

Xeroderma Pigmentosum Variant

Xp - [Xeroderma Pigmentosum]

Atrophoderma Pigmentosum

Xeroderma Pigmentosum, Complementation Group C

Xeroderma Pigmentosum, Group C

XPC

Xpcc

Xeroderma Pigmentosum Iii

Xp3

Xeroderma Pigmentosum Group C

Xp Group C

Xp, Group C

Xeroderma Pigmentosum, Type 3

Xeroderma Pigmentosum Complementation Group C

XP-C

Angelman Syndrome

AS

Happy Puppet Syndrome

Happy Puppet Syndrome, Formerly

Puppetlike Syndrome

Brain Sarcoma

Sarcoma Of The Brain

Hyperinsulinemic Hypoglycemia, Familial, 2

Persistent Hyperinsulinemic Hypoglycemia Of Infancy

Phhi

Familial Hyperinsulinism

Congenital Hyperinsulinism

HHF2

Nesidioblastosis

Hyperinsulinemic Hypoglycemia Due To Focal Adenomatous Hyperplasia

Familial Hyperinsulinemic Hypoglycemia 2

Autosomal Recessive Hyperinsulinemic Hypoglycemia Due To Kir6.2 Deficiency

Chi

Congenital Isolated Hyperinsulinism

Hyperinsulinemic Hypoglycemia, Persistent

Hyperinsulinism, Neonatal

Hyperinsulinism, Congenital

Hyperinsulinism, Familial

Hyperinsulinemic Hypoglycemia Familial

Hyperinsulinism Congenital

Hyperinsulinism Familial With Pancreatic Nesidioblastosis

Hypoglycemia Hyperinsulinemic Of Infancy

Nesidioblastosis Of Pancreas

Hyperinsulinemic Hypoglycemia Familial 2

Hyperinsulinemia Hypoglycemia Of Infancy

Infancy Hyperinsulinemia Hypoglycemia

Neonatal Hyperinsulinism

Persistent Hyperinsulinemia Hypoglycemia Of Infancy

Persistent Hyperinsulinemic Hypoglycemia

Phhi Hypoglycemia

Autosomal Dominant Hyperinsulinism Due To Kir6.2 Deficiency

Autosomal Dominant Hyperinsulinemic Hypoglycemia Due To Kir6.2 Deficiency

Dominant Katp Hyperinsulinism Due To Kir6.2 Deficiency

Diazoxide-Resistant Focal Hyperinsulinism Due To Kir6.2 Deficiency

Hyperinsulinemic Hypoglycemia Due To Kir6.2 Deficiency, Diazoxide-Resistant Focal Form

Fhi

Familial Hyperinsulinemic Hypoglycemia

Autosomal Recessive Hyperinsulinism Due To Kir6.2 Deficiency

Hypoglycemia, Hyperinsulinemic, Familial, Type 2

Hi-C

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta RAD23A VGNC VGNC:76643
Felis catus RAD23A VGNC VGNC:69213
Mus musculus RAD23A MGD MGI:105126
Rattus norvegicus RAD23A RGD RGD:1309899
Canis familiaris RAD23A VGNC VGNC:45315
Bos taurus RAD23A VGNC VGNC:33682