2. Gene
  3. ZFAND6 - zinc finger AN1-type containing 6 Gene

ZFAND6 - zinc finger AN1-type containing 6 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：含锌指 AN1 型 6

种属: Homo sapiens

同用名: AWP1; ZA20D3; ZFAND5B

基因 ID: 54469 | 基因类型: protein coding

关于 ZFAND6

Cytogenetic location: 15q25.1 Genomic coordinates (GRCh38): 15:80,058,951-80,138,393 (from NCBI)

This gene has 24 transcripts (splice variants), 151 orthologues and 2 paralogues. Ubiquitous expression in testis (RPKM 50.8), thyroid (RPKM 41.4) and 25 other tissues.

功能概要

预测可启用多聚泛素修饰依赖性蛋白结合活性。参与细胞对肿瘤坏死因子的反应；细胞凋亡过程的负调控；和调节 I-kappaB 激酶/NF-kappaB 信号。预测位于胞质溶胶中。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable polyubiquitin modification-dependent protein binding activity. Involved in cellular response to tumor necrosis factor; negative regulation of apoptotic process; and regulation of I-kappaB kinase/NF-kappaB signaling. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]

ZFAND6 基因产物(10)

mRNA Protein Name
NM_001242911.2 NP_001229840.1 AN1-type zinc finger protein 6 isoform a
NM_001242912.2 NP_001229841.1 AN1-type zinc finger protein 6 isoform a
NM_001242913.2 NP_001229842.1 AN1-type zinc finger protein 6 isoform a
NM_001242914.2 NP_001229843.1 AN1-type zinc finger protein 6 isoform a
NM_001242915.2 NP_001229844.1 AN1-type zinc finger protein 6 isoform a
NM_001242916.2 NP_001229845.1 AN1-type zinc finger protein 6 isoform a
NM_001242917.2 NP_001229846.1 AN1-type zinc finger protein 6 isoform b
NM_001242918.2 NP_001229847.1 AN1-type zinc finger protein 6 isoform c
NM_001242919.1 NP_001229848.1 AN1-type zinc finger protein 6 isoform d
NM_019006.4 NP_061879.2 AN1-type zinc finger protein 6 isoform a
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
16189514 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to tumor necrosis factor IMP
IMP: 通过突变表型推断
21810480 GOA
involved in negative regulation of apoptotic process IMP
IMP: 通过突变表型推断
21810480 GOA
involved in regulation of canonical NF-kappaB signal transduction IMP
IMP: 通过突变表型推断
21810480 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ZFAND6 蛋白结构

zf-A20

zf-A20: A20-like zinc finger (11 - 35)

zf-AN1

zf-AN1: AN1-like Zinc finger (149 - 188)

  • 0
  • 100
  • 208 a.a.
蛋白主名 其他名称

AN1-type zinc finger protein 6

protein associated with PRK1

ZFAND6 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
ZFAND6 Q6FIF0 TRAF2 Homo sapiens Q12933
Anti Tag CoIP
33961781
种属内
ZFAND6 Q6FIF0 TRAF2 Homo sapiens Q12933
Anti Bait CoIP
21810480
种属内
ZFAND6 Q6FIF0 TRAF2 Homo sapiens Q12933
Anti Tag CoIP
21810480
种属内
ZFAND6 Q6FIF0 TRAF5 Homo sapiens O00463
Y2H Array
25416956
种属内
ZFAND6 Q6FIF0 TRAF5 Homo sapiens O00463
Y2H Prey Pooling
25416956
种属内
ZFAND6 Q6FIF0 TRAF5 Homo sapiens O00463
Validated Y2H
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Peroxisome Biogenesis Disorder 1b

Peroxisome Biogenesis Disorder

Infantile Refsum Disease

Infantile Phytanic Acid Storage Disease

PBD1B

Refsum Disease, Infantile

Adrenoleukodystrophy, Autosomal Neonatal

Ird

Mild Pbd-Zsd

Mild Peroxisome Biogenesis Disorder-Zellweger Spectrum Disorder

Pbd-Zsd

Peroxisome Biogenesis Disorder Spectrum

Peroxisome Biogenesis Disorder-Zellweger Spectrum Disorder

Autosomal Neonatal Adrenoleukodystrophy

Refsum Disease Infantile

Peroxisome Biogenesis Disorders

Peroxisome Biogenesis Disorder, Type 1b
Zellweger Syndrome

Cerebrohepatorenal Syndrome

Zellweger Leukodystrophy

Zs

Congenital Iron Overload

Chr

Zws

Severe Pbd-Zsd

Severe Peroxisome Biogenesis Disorder-Zellweger Spectrum Disorder
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS16032 ZFAND6 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus ZFAND6 RGD RGD:1359317
Canis familiaris ZFAND6 VGNC VGNC:103715
Bos taurus ZFAND6 VGNC VGNC:107038
Mus musculus ZFAND6 MGD MGI:1929510
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