2. Gene
  3. TRAF5 - TNF receptor associated factor 5 Gene

TRAF5 - TNF receptor associated factor 5 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：TNF 受体相关因子 5

种属: Homo sapiens

同用名: RNF84; MGC:39780

基因 ID: 7188 | 基因类型: protein coding

关于 TRAF5

Cytogenetic location: 1q32.3 Genomic coordinates (GRCh38): 1:211,326,635-211,374,946 (from NCBI)

This gene has 7 transcripts (splice variants), 143 orthologues and 5 paralogues. Broad expression in lymph node (RPKM 13.9), appendix (RPKM 8.7) and 24 other tissues.

功能概要

该基因编码的支架蛋白是肿瘤坏死因子受体相关因子 (TRAF) 蛋白家族的成员，包含安眠蛋白和 TRAF 同源 (MATH) 结构域、一个 RING 型锌指和两个 TRAF 型锌指. TRAF 蛋白与 TNF 受体超家族成员相关并介导信号转导。该蛋白是多蛋白复合物的成分之一，可与肿瘤坏死因子 (TNF) 受体胞质结构域结合并介导 TNF 诱导的激活。已发现该基因编码不同异构体的多个转录变体。[RefSeq 提供，2016 年 1 月]

The scaffold protein encoded by this gene is a member of the tumor necrosis factor receptor-associated factor (TRAF) protein family and contains a meprin and TRAF homology (MATH) domain, a RING-type zinc finger, and two TRAF-type zinc fingers. TRAF proteins are associated with, and mediate signal transduction from members of the TNF Receptor Superfamily. This protein is one of the components of a multiple protein complex which binds to tumor necrosis factor (TNF) receptor cytoplasmic domains and mediates TNF-induced activation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]

TRAF5 基因产物(4)

mRNA Protein Name
NM_001033910.3 NP_001029082.1 TNF receptor-associated factor 5 isoform b
NM_001319207.2 NP_001306136.1 TNF receptor-associated factor 5 isoform a
NM_004619.4 NP_004610.1 TNF receptor-associated factor 5 isoform b
NM_145759.3 NP_665702.1 TNF receptor-associated factor 5 isoform b
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables identical protein binding IPI
IPI: 通过物理相互作用推断
22493164 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
9153189 GOA
enables thioesterase binding IPI
IPI: 通过物理相互作用推断
11279055 GOA
enables ubiquitin protein ligase activity IDA
IDA: 通过直接分析推断
26453305 GOA
enables ubiquitin protein ligase binding IPI
IPI: 通过物理相互作用推断
11279055 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in CD40 signaling pathway IDA
IDA: 通过直接分析推断
15708970 GOA
involved in positive regulation of DNA-binding transcription factor activity IMP
IMP: 通过突变表型推断
12296995 GOA
involved in positive regulation of NF-kappaB transcription factor activity IMP
IMP: 通过突变表型推断
12296995 GOA
involved in positive regulation of canonical NF-kappaB signal transduction IEP
IEP: 通过表达模式推断
12761501 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in centrosome IDA
IDA: 通过直接分析推断
21399614 GOA
is active in cytoplasm IDA
IDA: 通过直接分析推断
15121867 GOA
located in cytosol IDA
IDA: 通过直接分析推断
15121867 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TRAF5 蛋白结构

zf-C3HC4

zf-C3HC4: Zinc finger, C3HC4 type (RING finger) (45 - 82)

zf-TRAF

zf-TRAF: TRAF-type zinc finger (183 - 241)

MATH

MATH: MATH domain (417 - 550)

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  • 557 a.a.
蛋白主名 其他名称

TNF receptor-associated factor 5

RING finger protein 84

TRAF5 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra TRAF5 O00463 ENOX2 Homo sapiens Q16206-2
Y2H Prey Pooling
25416956
Intra TRAF5 O00463 CCDC184 Homo sapiens Q52MB2
Y2H Prey Pooling
32296183
Intra TRAF5 O00463 CCDC184 Homo sapiens Q52MB2
Validated Y2H
32296183
Intra TRAF5 O00463 CCDC184 Homo sapiens Q52MB2
Y2H Array
32296183
Intra TRAF5 O00463 CIB3 Homo sapiens Q96Q77
Validated Y2H
32296183
Intra TRAF5 O00463 SEC13 Homo sapiens P55735
Y2H Prey Pooling
25416956
Intra TRAF5 O00463 GAS8 Homo sapiens O95995
Validated Y2H
32296183
Intra TRAF5 O00463 STIP1 Homo sapiens P31948
Validated Y2H
32814053
Intra TRAF5 O00463 STIP1 Homo sapiens P31948
Y2H Pooling
32814053
Intra TRAF5 O00463 STIP1 Homo sapiens P31948
Y2H Array
32814053
Intra TRAF5 O00463 TNFRSF14 Homo sapiens Q92956
CoIP
9153189
Intra TRAF5 O00463 TNFRSF14 Homo sapiens Q92956
Y2H
9153189
Intra TRAF5 O00463 YPEL5 Homo sapiens P62699
Validated Y2H
32296183
Intra TRAF5 O00463 SEC13 Homo sapiens P55735-3
Validated Y2H
32296183
Intra TRAF5 O00463 PIBF1 Homo sapiens Q4G0R1
Validated Y2H
32296183
Intra TRAF5 O00463 MEOX2 Homo sapiens Q6FHY5
Validated Y2H
32296183
Intra TRAF5 O00463 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
Intra TRAF5 O00463 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
Intra TRAF5 O00463 LAMP2 Homo sapiens P13473-2
Validated Y2H
32814053
Intra TRAF5 O00463 LAMP2 Homo sapiens P13473-2
Y2H Pooling
32814053
Intra TRAF5 O00463 LAMP2 Homo sapiens P13473-2
Y2H Array
32814053
Intra TRAF5 O00463 RNF4 Homo sapiens P78317
Validated Y2H
32296183
Intra TRAF5 O00463 RNF4 Homo sapiens P78317
Y2H Array
32296183
Intra TRAF5 O00463 RNF4 Homo sapiens P78317
Y2H Prey Pooling
32296183
Intra TRAF5 O00463 LMO4 Homo sapiens P61968
Validated Y2H
32296183
Intra TRAF5 O00463 CDC37 Homo sapiens Q16543
Validated Y2H
32296183
Intra TRAF5 O00463 PIAS2 Homo sapiens O75928-2
Validated Y2H
32296183
Intra TRAF5 O00463 PIAS2 Homo sapiens O75928-2
Y2H Array
32296183
Intra TRAF5 O00463 PIAS2 Homo sapiens O75928-2
Y2H Prey Pooling
32296183
Intra TRAF5 O00463 TRAF2 Homo sapiens Q12933
Y2H Prey Pooling
32296183
Intra TRAF5 O00463 TRAF2 Homo sapiens Q12933
Validated Y2H
32296183
Intra TRAF5 O00463 TRAF2 Homo sapiens Q12933
Y2H Array
32296183
Intra TRAF5 O00463 TRAF3 Homo sapiens Q13114
PLA
25241761
Intra TRAF5 O00463 TRAF3 Homo sapiens Q13114
Y2H Prey Pooling
32296183
Intra TRAF5 O00463 TRAF3 Homo sapiens Q13114
Validated Y2H
32296183
Intra TRAF5 O00463 TRAF3 Homo sapiens Q13114
Y2H Array
32296183
Intra TRAF5 O00463 TRAF6 Homo sapiens Q9Y4K3
Y2H Prey Pooling
32296183
Intra TRAF5 O00463 TRAF6 Homo sapiens Q9Y4K3
Y2H
21516116
Intra TRAF5 O00463 TRAF6 Homo sapiens Q9Y4K3
Validated Y2H
27107012
Intra TRAF5 O00463 TRAF6 Homo sapiens Q9Y4K3
Validated Y2H
32296183
Intra TRAF5 O00463 TRAF6 Homo sapiens Q9Y4K3
Y2H Array
32296183
Intra TRAF5 O00463 TRAF6 Homo sapiens Q9Y4K3
Y2H Prey Pooling
25416956
Intra TRAF5 O00463 PSMA1 Homo sapiens P25786
Validated Y2H
32296183
Intra TRAF5 O00463 NMI Homo sapiens Q13287
Y2H Array
25416956
Intra TRAF5 O00463 NMI Homo sapiens Q13287
Validated Y2H
27107012
Intra TRAF5 O00463 NMI Homo sapiens Q13287
Y2H Array
32296183
Intra TRAF5 O00463 NMI Homo sapiens Q13287
Y2H
21516116
Intra TRAF5 O00463 NMI Homo sapiens Q13287
Validated Y2H
32296183
Intra TRAF5 O00463 NMI Homo sapiens Q13287
Validated Y2H
25416956
Intra TRAF5 O00463 NMI Homo sapiens Q13287
Y2H Prey Pooling
25416956
Intra TRAF5 O00463 NMI Homo sapiens Q13287
Y2H Prey Pooling
32296183
Intra TRAF5 O00463 SRSF1 Homo sapiens Q07955
Anti Bait CoIP
21822258
Intra TRAF5 O00463 SPRED1 Homo sapiens Q7Z699
Validated Y2H
32814053
Intra TRAF5 O00463 SPRED1 Homo sapiens Q7Z699
Y2H Array
32814053
Intra TRAF5 O00463 SPRED1 Homo sapiens Q7Z699
Y2H Pooling
32814053
Intra TRAF5 O00463 ZNF655 Homo sapiens Q8N720
Y2H Prey Pooling
32296183
Intra TRAF5 O00463 ZNF655 Homo sapiens Q8N720
Y2H Array
32296183
Intra TRAF5 O00463 ZNF655 Homo sapiens Q8N720
Validated Y2H
32296183
Intra TRAF5 O00463 HSF2BP Homo sapiens O75031
Validated Y2H
32296183
Intra TRAF5 O00463 HSF2BP Homo sapiens O75031
Y2H Prey Pooling
32296183
Intra TRAF5 O00463 HSF2BP Homo sapiens O75031
Y2H Array
32296183
Intra TRAF5 O00463 SERPINB9 Homo sapiens P50453
Y2H Array
25416956
Intra TRAF5 O00463 SERPINB9 Homo sapiens P50453
Validated Y2H
32296183
Intra TRAF5 O00463 SERPINB9 Homo sapiens P50453
Validated Y2H
25416956
Intra TRAF5 O00463 PHYH Homo sapiens O14832
Y2H Pooling
32814053
Intra TRAF5 O00463 PHYH Homo sapiens O14832
Validated Y2H
32814053
Intra TRAF5 O00463 PHYH Homo sapiens O14832
Y2H Array
32814053
Intra TRAF5 O00463 SDCBP Homo sapiens O00560
Y2H Prey Pooling
25416956
Intra TRAF5 O00463 SDCBP Homo sapiens O00560
Validated Y2H
25416956
Intra TRAF5 O00463 SDCBP Homo sapiens O00560
Validated Y2H
32296183
Intra TRAF5 O00463 GORASP2 Homo sapiens Q9H8Y8
Validated Y2H
25416956
Intra TRAF5 O00463 LNX1 Homo sapiens Q8TBB1
Validated Y2H
32296183
Intra TRAF5 O00463 FBXO28 Homo sapiens Q9NVF7
Validated Y2H
32296183
Intra TRAF5 O00463 NTAQ1 Homo sapiens Q96HA8
Validated Y2H
32296183
Intra TRAF5 O00463 THAP7 Homo sapiens Q9BT49
Validated Y2H
32296183
Intra TRAF5 O00463 THAP1 Homo sapiens Q9NVV9
Validated Y2H
32296183
Intra TRAF5 O00463 THAP1 Homo sapiens Q9NVV9
Y2H Array
32296183
Intra TRAF5 O00463 THAP1 Homo sapiens Q9NVV9
Y2H Prey Pooling
32296183
Intra TRAF5 O00463 RAD23A Homo sapiens P54725
Y2H Prey Pooling
25416956
Intra TRAF5 O00463 HOMER1 Homo sapiens Q86YM7
Validated Y2H
32296183
Intra TRAF5 O00463 HOMER1 Homo sapiens Q86YM7
Y2H Array
32296183
Intra TRAF5 O00463 HOMER1 Homo sapiens Q86YM7
Y2H Prey Pooling
32296183
Intra TRAF5 O00463 PICK1 Homo sapiens Q9NRD5
Y2H Prey Pooling
32296183
Intra TRAF5 O00463 PICK1 Homo sapiens Q9NRD5
Validated Y2H
32296183
Intra TRAF5 O00463 PICK1 Homo sapiens Q9NRD5
Y2H Array
32296183
Intra TRAF5 O00463 SUMO1 Homo sapiens P63165
Y2H Prey Pooling
32296183
Intra TRAF5 O00463 SUMO1 Homo sapiens P63165
Validated Y2H
32296183
Intra TRAF5 O00463 SUMO1 Homo sapiens P63165
Y2H Array
32296183
Intra TRAF5 O00463 FAM9A Homo sapiens Q8IZU1
Validated Y2H
32296183
Intra TRAF5 O00463 FAM9A Homo sapiens Q8IZU1
Y2H Array
32296183
Intra TRAF5 O00463 FAM9A Homo sapiens Q8IZU1
Y2H Prey Pooling
32296183
Intra TRAF5 O00463 ODF2 Homo sapiens Q5BJF6-2
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Myeloma, Multiple

Multiple Myeloma

Plasma Cell Myeloma

Kahler Disease

Myelomatosis

Medullary Plasmacytoma

Multiple Myeloma, Resistance To

Myeloma

Plasma Cell Dyscrasia

Kahler'S Disease

Multiple Myeloma, Susceptibility To

Myeloma - Multiple

Kahler-Bozzolo Disease

Plasma Cell Myelomas

MM

Plasma Cell Neoplasm

Primary Systemic Amyloidosis

Primary Amyloidosis

Immunoglobulin Deposition Disease

Plasmacytic Myeloma

Multiple Myelomata

Multiple Myeloma Nos

Multiple Myeloma Without Mention Of Remission

Monostotic Plasma Cell Myeloma

Mm - [Multiple Myeloma]
Plasma Cell Neoplasm

Plasma Cell Dyscrasia

Paraproteinemias

Plasma Cell Tumour

Plasmacytic Tumor

Multiple Myeloma

Plasmacytoma

Plasma Cell Tumours

Plasma Cells Dyscrasia
Ectodermal Dysplasia

Congenital Ectodermal Defect

Congenital Ectodermal Dysplasia

Ectodermal Dysplasia Syndrome

Dysplasia, Ectodermal
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS14974 TRAF5 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris TRAF5 VGNC VGNC:47769
Bos taurus TRAF5 VGNC VGNC:36277
Rattus norvegicus TRAF5 RGD RGD:1593883
Felis catus TRAF5 VGNC VGNC:66501
Macaca mulatta TRAF5 VGNC VGNC:78644
Mus musculus TRAF5 MGD MGI:107548
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