1. Gene
  2. HOMER1 - homer scaffold protein 1 Gene

HOMER1 - homer scaffold protein 1 Gene

中文名称:荷马支架蛋白 1

种属: Homo sapiens

同用名: HOMER; SYN47; Ves-1; HOMER1A; HOMER1B; HOMER1C

基因 ID: 9456 | 基因类型: protein coding

关于 HOMER1

Cytogenetic location: 5q14.1 Genomic coordinates (GRCh38): 5:79,372,636-79,514,134 (from NCBI)

This gene has 5 transcripts (splice variants), 268 orthologues and 2 paralogues. Broad expression in brain (RPKM 8.6), thyroid (RPKM 5.8) and 14 other tissues.

功能概要

该基因编码树突状蛋白荷马家族的一个成员。该家族的成员调节第 1 组代谢型谷氨酸受体功能。[RefSeq 提供,2008 年 7 月]

This gene encodes a member of the homer family of dendritic proteins. Members of this family regulate group 1 metabotrophic glutamate receptor function. [provided by RefSeq, Jul 2008]

HOMER1 基因产物(3)

mRNA Protein Name
NM_001277077.1 NP_001264006.1 homer protein homolog 1 isoform 2
NM_001277078.1 NP_001264007.1 homer protein homolog 1 isoform 3
NM_004272.5 NP_004263.1 homer protein homolog 1 isoform 1
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
16189514 GOA
enables transmembrane transporter binding IPI
IPI: 通过物理相互作用推断
14505576 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in response to calcium ion IDA
IDA: 通过直接分析推断
14505576 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

HOMER1 蛋白结构

WH1

WH1: WH1 domain (4 - 106)

  • 0
  • 100
  • 200
  • 300
  • 354 a.a.
蛋白主名 其他名称

homer protein homolog 1

homer homolog 1

HOMER1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra HOMER1 Q86YM7 ABI1 Homo sapiens Q8IZP0-5
Y2H Prey Pooling
32296183
Intra HOMER1 Q86YM7 ABI1 Homo sapiens Q8IZP0-5
Y2H Array
32296183
Intra HOMER1 Q86YM7 ABI1 Homo sapiens Q8IZP0-5
Validated Y2H
32296183
Intra HOMER1 Q86YM7 SYCE2 Homo sapiens Q6PIF2
Y2H Prey Pooling
32296183
Intra HOMER1 Q86YM7 SYCE2 Homo sapiens Q6PIF2
Y2H Array
32296183
Intra HOMER1 Q86YM7 SHANK2 Homo sapiens Q9UPX8-4
Y2H Array
32296183
Intra HOMER1 Q86YM7 SHANK2 Homo sapiens Q9UPX8-4
Y2H Prey Pooling
32296183
Intra HOMER1 Q86YM7 SHANK2 Homo sapiens Q9UPX8-4
Validated Y2H
32296183
Intra HOMER1 Q86YM7 INADL Homo sapiens A5PKX9
Y2H Prey Pooling
32296183
Intra HOMER1 Q86YM7 INADL Homo sapiens A5PKX9
Y2H Array
32296183
Intra HOMER1 Q86YM7 AIMP1 Homo sapiens Q12904-2
Y2H Array
32296183
Intra HOMER1 Q86YM7 AIMP1 Homo sapiens Q12904-2
Y2H Prey Pooling
32296183
Intra HOMER1 Q86YM7 ZMYM5 Homo sapiens Q9UJ78-2
Y2H Prey Pooling
32296183
Intra HOMER1 Q86YM7 ZMYM5 Homo sapiens Q9UJ78-2
Validated Y2H
32296183
Intra HOMER1 Q86YM7 ZMYM5 Homo sapiens Q9UJ78-2
Y2H Array
32296183
Intra HOMER1 Q86YM7 SARG Homo sapiens Q9BW04
Y2H Prey Pooling
32296183
Intra HOMER1 Q86YM7 SARG Homo sapiens Q9BW04
Y2H Array
32296183
Intra HOMER1 Q86YM7 SARG Homo sapiens Q9BW04
Y2H Pooling
19447967
Intra HOMER1 Q86YM7 SARG Homo sapiens Q9BW04
Validated Y2H
32296183
Intra HOMER1 Q86YM7 SARG Homo sapiens Q9BW04
Validated Y2H
25416956
Intra HOMER1 Q86YM7 CENPQ Homo sapiens Q7L2Z9
Y2H Array
32296183
Intra HOMER1 Q86YM7 CENPQ Homo sapiens Q7L2Z9
Y2H Prey Pooling
32296183
Intra HOMER1 Q86YM7 RASAL3 Homo sapiens Q86YV0
Validated Y2H
32296183
Intra HOMER1 Q86YM7 RASAL3 Homo sapiens Q86YV0
Y2H Array
32296183
Intra HOMER1 Q86YM7 RASAL3 Homo sapiens Q86YV0
Y2H Prey Pooling
32296183
Intra HOMER1 Q86YM7 PIAS2 Homo sapiens O75928-2
Y2H Prey Pooling
32296183
Intra HOMER1 Q86YM7 PIAS2 Homo sapiens O75928-2
Y2H Array
32296183
Intra HOMER1 Q86YM7 TRAF5 Homo sapiens O00463
Anti Tag CoIP
28514442
Intra HOMER1 Q86YM7 TRAF5 Homo sapiens O00463
Anti Tag CoIP
33961781
Intra HOMER1 Q86YM7 BRME1 Homo sapiens Q0VDD7
Y2H Prey Pooling
25416956
Intra HOMER1 Q86YM7 ABI3 Homo sapiens Q9P2A4
Validated Y2H
32296183
Intra HOMER1 Q86YM7 HOMER3 Homo sapiens Q9NSC5
Anti Tag CoIP
35271311
Intra HOMER1 Q86YM7 HOMER3 Homo sapiens Q9NSC5
Validated Y2H
25416956
Intra HOMER1 Q86YM7 HOMER3 Homo sapiens Q9NSC5
Complementation
32296183
Intra HOMER1 Q86YM7 HOMER3 Homo sapiens Q9NSC5
Y2H Prey Pooling
25416956
Intra HOMER1 Q86YM7 HOMER3 Homo sapiens Q9NSC5
Validated Y2H
32296183
Intra HOMER1 Q86YM7 HOMER3 Homo sapiens Q9NSC5
Y2H Array
25416956
Intra HOMER1 Q86YM7 HOMER3 Homo sapiens Q9NSC5
Y2H Prey Pooling
32296183
Intra HOMER1 Q86YM7 HOMER3 Homo sapiens Q9NSC5
Y2H Array
32296183
Intra HOMER1 Q86YM7 HOMER3 Homo sapiens Q9NSC5
MAPPIT
25416956
Intra HOMER1 Q86YM7 HOMER3 Homo sapiens Q9NSC5
Anti Tag CoIP
25416956
Intra HOMER1 Q86YM7 FAM9A Homo sapiens Q8IZU1
Y2H Prey Pooling
32296183
Intra HOMER1 Q86YM7 FAM9A Homo sapiens Q8IZU1
Validated Y2H
32296183
Intra HOMER1 Q86YM7 FAM9A Homo sapiens Q8IZU1
Y2H Array
32296183
Intra HOMER1 Q86YM7 RAD54L2 Homo sapiens Q9Y4B4
Validated Y2H
32296183
Intra HOMER1 Q86YM7 RAD54L2 Homo sapiens Q9Y4B4
Y2H Array
32296183
Intra HOMER1 Q86YM7 RAD54L2 Homo sapiens Q9Y4B4
Y2H Prey Pooling
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Fragile X Syndrome

FXS

Martin-Bell Syndrome

Fraxa Syndrome

Marker X Syndrome

X-Linked Mental Retardation And Macroorchidism

Fragile X Mental Retardation Syndrome

Fra Syndrome

Mental Retardation, X-Linked, Associated With Marxq28

X-Linked Intellectual Disability And Macroorchidism

Frax Syndrome

Symptomatic Form Of Fragile X Syndrome In Female Carriers

Fragile-X Syndrome

Fraxe Syndrome

Deafness, Autosomal Dominant 68

DFNA68

Autosomal Dominant Nonsyndromic Deafness 68

Autosomal Dominant Deafness 68

Deafness, Autosomal Dominant, 68

Autism

Autistic Disorder

Autism Susceptibility 1

Childhood Autism

Autistic Disorder Of Childhood Onset

Infantile Autism

Kanner'S Syndrome

Autistic

Ogden Syndrome

OGDNS

N-Terminal Acetyltransferase Deficiency

NATD

N-Alpha-Acetyltransferase

X-Linked Malformation And Infantile Lethality Syndrome

Premature Aging Appearance-Developmental Delay-Cardiac Arrhythmia Syndrome

Phelan-Mcdermid Syndrome

Chromosome 22q13.3 Deletion Syndrome

22q13.3 Deletion Syndrome

Telomeric 22q13 Monosomy Syndrome

PHMDS

Deletion 22q13 Syndrome

22q13.3 Deletion

Deletion 22q13.3 Syndrome

Monosomy 22q13

Monosomy 22q13.3

22q13 Deletion Syndrome

Monosomy 22q13 Syndrome

22q13 Deletion

Chromosome Deletion

Autism Spectrum Disorder

Asd

Autism Spectrum Disorders

Autistic Continuum

Pervasive Developmental Disorder

Pervasive Development Disorder

Autistic Behavior

Autistic Disorder

Autistic

Autistic Disorder Of Childhood Onset

Infantile Autism

Childhood Autism

Kanner Syndrome

Pervasive Developmental Delay Nos

Pervasive Developmental Disorder, Not Otherwise Specified

Bipolar Disorder

Bipolar Depression

Manic Disorder

Depression, Bipolar

Bipolar Disorder Manic Phase

Depressive-Manic Psych.

Manic Bipolar Affective Disorder

Manic Bipolar I Disorder

Manic Depression

Manic Depressive Disorder

Mixed Bipolar Disorder

Bipolar Affective Disorder

Bipolar Affective Psychosis

Bipolar Spectrum Disorder

Manic Depressive Illness

Depression Bipolar

Bipolar Disorder, Mixed

Major Affective Disorder

Major Affective Disorder 1

Major Affective Disorder 2

Pervasive Developmental Disorder

Pervasive Development Disorder

Pervasive Developmental Disorders

Pervasive Child Development Disorders

Autistic Behavior

Autism Spectrum Disorders

Schizophrenia

SCZD

Schizophrenia With Or Without An Affective Disorder

Schizophrenia 12

Schizophrenia, Susceptibility To

Schizophrenia-1

Dementia Praecox

Schizophrenia 1

Attention Deficit-Hyperactivity Disorder

Attention Deficit Hyperactivity Disorder

ADHD

Attention Deficit Disorder

Attention Deficit-Hyperactivity Disorder, Susceptibility To

Attention Deficit Disorder With Hyperactivity

Hyperkinetic Disorder

Hyperactivity Of Childhood

Attention-Deficit/Hyperactivity Disorder

Add

Addh

Attention Deficit

Attention Deficit Disorder Of Childhood With Hyperactivity

Attention Deficit Disorder With Hyperactivity Syndrome

Hyperkinetic Syndrome

Attention-Deficit Hyperactivity Disorder

Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type

Disturbance Of Activity And Attention

Disorder Of Activity And Attention

Adhd - [Attention Deficit Hyperactivity Disorder]

Hyperkinetic Disorders

Disorder Of Activity And Attention With Hyperkinesia

Attention Deficit Syndrome With Hyperactivity

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta HOMER1 VGNC VGNC:73405
Mus musculus HOMER1 MGD MGI:1347345
Felis catus HOMER1 VGNC VGNC:62830
Canis familiaris HOMER1 VGNC VGNC:41737
Rattus norvegicus HOMER1 RGD RGD:628725
Bos taurus HOMER1 VGNC VGNC:29901