2. Gene
  3. ABI3 - ABI family member 3 Gene

ABI3 - ABI family member 3 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：ABI 家族成员 3

种属: Homo sapiens

同用名: NESH; SSH3BP3

基因 ID: 51225 | 基因类型: protein coding

关于 ABI3

Cytogenetic location: 17q21.32 Genomic coordinates (GRCh38): 17:49,210,707-49,223,225 (from NCBI)

This gene has 4 transcripts (splice variants), 181 orthologues and 2 paralogues. Broad expression in spleen (RPKM 23.3), lymph node (RPKM 10.1) and 21 other tissues.

功能概要

该基因编码衔接蛋白家族的一个成员。该家族的成员编码的蛋白质包含同源盒同源结构域、富含脯氨酸的区域和 Src 同源 3 (SH3) 结构域，并且是调节肌动蛋白聚合的 Abi/WAVE 复合物的组分。编码的蛋白质抑制肿瘤细胞的异位转移以及细胞迁移。这可以通过与 p21 激活激酶的相互作用来实现。可变剪接导致多个转录本变体。[RefSeq 提供，2013 年 9 月]

This gene encodes a member of an adaptor protein family. Members of this family encode proteins containing a homeobox homology domain, proline rich region and Src-homology 3 (SH3) domain, and are components of the Abi/WAVE complex which regulates actin polymerization. The encoded protein inhibits ectopic metastasis of tumor cells as well as cell migration. This may be accomplished through interaction with p21-activated kinase. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

ABI3 基因产物(2)

mRNA Protein Name
NM_001135186.2 NP_001128658.2 ABI gene family member 3 isoform 2
NM_016428.3 NP_057512.2 ABI gene family member 3 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables identical protein binding IPI
IPI: 通过物理相互作用推断
25416956 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
16189514 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in defense response to tumor cell IMP
IMP: 通过突变表型推断
21223585 GOA
NOT acts upstream of or within peptidyl-tyrosine phosphorylation IDA
IDA: 通过直接分析推断
17101133 GOA
involved in positive regulation of cellular senescence IMP
IMP: 通过突变表型推断
21223585 GOA
acts upstream of or within regulation of cell migration IDA
IDA: 通过直接分析推断
11956071 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of SCAR complex IDA
IDA: 通过直接分析推断
17101133 GOA
located in lamellipodium IDA
IDA: 通过直接分析推断
17101133 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ABI3 蛋白结构

Abi_HHR

Abi_HHR: Abl-interactor HHR (93 - 165)

SH3_9

SH3_9: Variant SH3 domain (316 - 363)

  • 0
  • 100
  • 200
  • 300
  • 366 a.a.
蛋白主名 其他名称

ABI gene family member 3

new molecule including SH3

ABI3 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra ABI3 Q9P2A4 KRT13 Homo sapiens A1A4E9
Y2H Prey Pooling
25416956
Intra ABI3 Q9P2A4 b2r8y4_human Homo sapiens B2R8Y4
Y2H Array
25416956
Intra ABI3 Q9P2A4 EIF3S3 Homo sapiens Q6IB98
Validated Y2H
25416956
Intra ABI3 Q9P2A4 EIF3S3 Homo sapiens Q6IB98
Y2H Array
25416956
Intra ABI3 Q9P2A4 EIF3S3 Homo sapiens Q6IB98
Y2H Prey Pooling
25416956
Intra ABI3 Q9P2A4 RUNX1T1 Homo sapiens Q06455-4
Validated Y2H
25416956
Intra ABI3 Q9P2A4 FBF1 Homo sapiens Q8TES7-6
Y2H Prey Pooling
25416956
Intra ABI3 Q9P2A4 FBF1 Homo sapiens Q8TES7-6
Validated Y2H
25416956
Intra ABI3 Q9P2A4 FBF1 Homo sapiens Q8TES7-6
Y2H Array
25416956
Intra ABI3 Q9P2A4 KRT38 Homo sapiens O76015
Y2H Prey Pooling
32296183
Intra ABI3 Q9P2A4 KRT38 Homo sapiens O76015
Y2H Array
32296183
Intra ABI3 Q9P2A4 KRT35 Homo sapiens Q92764
Y2H Prey Pooling
32296183
Intra ABI3 Q9P2A4 KRT35 Homo sapiens Q92764
Y2H Array
32296183
Intra ABI3 Q9P2A4 MIS18A Homo sapiens Q9NYP9
Y2H Array
32296183
Intra ABI3 Q9P2A4 MIS18A Homo sapiens Q9NYP9
Y2H Prey Pooling
32296183
Intra ABI3 Q9P2A4 GNG13 Homo sapiens Q9P2W3
Validated Y2H
32296183
Intra ABI3 Q9P2A4 EMILIN1 Homo sapiens Q9Y6C2-2
Validated Y2H
32296183
Intra ABI3 Q9P2A4 EMILIN1 Homo sapiens Q9Y6C2-2
Y2H Array
32296183
Intra ABI3 Q9P2A4 EMILIN1 Homo sapiens Q9Y6C2-2
Y2H Prey Pooling
32296183
Intra ABI3 Q9P2A4 STX2 Homo sapiens P32856-2
Y2H Prey Pooling
32296183
Intra ABI3 Q9P2A4 STX2 Homo sapiens P32856-2
Y2H Array
32296183
Intra ABI3 Q9P2A4 KRT36 Homo sapiens O76013-2
Y2H Prey Pooling
32296183
Intra ABI3 Q9P2A4 KRT36 Homo sapiens O76013-2
Y2H Array
32296183
Intra ABI3 Q9P2A4 KRT28 Homo sapiens Q7Z3Y7
Y2H Prey Pooling
32296183
Intra ABI3 Q9P2A4 KRT28 Homo sapiens Q7Z3Y7
Y2H Array
32296183
Intra ABI3 Q9P2A4 WASF1 Homo sapiens Q92558
Y2H Prey Pooling
32296183
Intra ABI3 Q9P2A4 WASF1 Homo sapiens Q92558
Y2H Array
32296183
Intra ABI3 Q9P2A4 CENPQ Homo sapiens Q7L2Z9
Y2H Prey Pooling
32296183
Intra ABI3 Q9P2A4 CENPQ Homo sapiens Q7L2Z9
Y2H Array
32296183
Intra ABI3 Q9P2A4 KANK2 Homo sapiens Q63ZY3
Validated Y2H
25416956
Intra ABI3 Q9P2A4 KANK2 Homo sapiens Q63ZY3
Y2H Array
25416956
Intra ABI3 Q9P2A4 DESI1 Homo sapiens Q6ICB0
Y2H Array
32296183
Intra ABI3 Q9P2A4 DESI1 Homo sapiens Q6ICB0
Y2H Prey Pooling
32296183
Intra ABI3 Q9P2A4 NUP58 Homo sapiens Q9BVL2
Y2H Prey Pooling
25416956
Intra ABI3 Q9P2A4 NUP58 Homo sapiens Q9BVL2
Y2H
21516116
Intra ABI3 Q9P2A4 NUP58 Homo sapiens Q9BVL2
Y2H Array
25416956
Intra ABI3 Q9P2A4 KRT24 Homo sapiens Q2M2I5
Y2H Prey Pooling
32296183
Intra ABI3 Q9P2A4 KRT24 Homo sapiens Q2M2I5
Y2H Array
32296183
Intra ABI3 Q9P2A4 WAS Homo sapiens P42768
Y2H Array
25416956
Intra ABI3 Q9P2A4 EVL Homo sapiens Q9UI08
Y2H Array
29892012
Intra ABI3 Q9P2A4 EVL Homo sapiens Q9UI08
Y2H Prey Pooling
25416956
Intra ABI3 Q9P2A4 EVL Homo sapiens Q9UI08
Validated Y2H
25416956
Intra ABI3 Q9P2A4 SH3BP1 Homo sapiens Q9Y3L3
Y2H Prey Pooling
32296183
Intra ABI3 Q9P2A4 SH3BP1 Homo sapiens Q9Y3L3
Validated Y2H
32296183
Intra ABI3 Q9P2A4 SH3BP1 Homo sapiens Q9Y3L3
Y2H Array
32296183
Intra ABI3 Q9P2A4 EIF3M Homo sapiens Q7L2H7
Y2H Prey Pooling
32296183
Intra ABI3 Q9P2A4 EIF3M Homo sapiens Q7L2H7
Y2H Array
32296183
Intra ABI3 Q9P2A4 PSMA1 Homo sapiens P25786
Y2H Array
25416956
Intra ABI3 Q9P2A4 PSMA1 Homo sapiens P25786
Y2H Prey Pooling
25416956
Intra ABI3 Q9P2A4 MED29 Homo sapiens Q9NX70
Y2H Prey Pooling
32296183
Intra ABI3 Q9P2A4 MED29 Homo sapiens Q9NX70
Y2H Array
32296183
Intra ABI3 Q9P2A4 GRB2 Homo sapiens P62993
Y2H Prey Pooling
25416956
Intra ABI3 Q9P2A4 GRB2 Homo sapiens P62993
Validated Y2H
25416956
Intra ABI3 Q9P2A4 GRB2 Homo sapiens P62993
Y2H Array
25416956
Intra ABI3 Q9P2A4 BLOC1S5 Homo sapiens Q8TDH9
Y2H Array
32296183
Intra ABI3 Q9P2A4 BLOC1S5 Homo sapiens Q8TDH9
Y2H Prey Pooling
32296183
Intra ABI3 Q9P2A4 OIP5 Homo sapiens O43482
Y2H Prey Pooling
32296183
Intra ABI3 Q9P2A4 OIP5 Homo sapiens O43482
Y2H Array
32296183
Intra ABI3 Q9P2A4 EVL Homo sapiens Q9UI08-2
Validated Y2H
32296183
Intra ABI3 Q9P2A4 KRT14 Homo sapiens P02533
Y2H Prey Pooling
32296183
Intra ABI3 Q9P2A4 KRT14 Homo sapiens P02533
Y2H Array
32296183
Intra ABI3 Q9P2A4 EIF3H Homo sapiens O15372
Y2H Prey Pooling
32296183
Intra ABI3 Q9P2A4 EIF3H Homo sapiens O15372
Y2H Array
19060904
Intra ABI3 Q9P2A4 EIF3H Homo sapiens O15372
Y2H Pooling
19060904
Intra ABI3 Q9P2A4 EIF3H Homo sapiens O15372
Y2H Array
32296183
Intra ABI3 Q9P2A4 GOLM1 Homo sapiens Q8NBJ4
Y2H Prey Pooling
32296183
Intra ABI3 Q9P2A4 GOLM1 Homo sapiens Q8NBJ4
Y2H Array
32296183
Intra ABI3 Q9P2A4 STX1A Homo sapiens Q16623
Y2H Prey Pooling
32296183
Intra ABI3 Q9P2A4 STX1A Homo sapiens Q16623
Y2H Array
32296183
Intra ABI3 Q9P2A4 NCK2 Homo sapiens O43639
Y2H Prey Pooling
25416956
Intra ABI3 Q9P2A4 RUFY3 Homo sapiens Q7L099
Y2H Prey Pooling
32296183
Intra ABI3 Q9P2A4 RUFY3 Homo sapiens Q7L099
Y2H Array
32296183
Intra ABI3 Q9P2A4 FARSA Homo sapiens Q9Y285
Validated Y2H
25416956
Intra ABI3 Q9P2A4 FARSA Homo sapiens Q9Y285
Y2H Array
25416956
Intra ABI3 Q9P2A4 KIAA0408 Homo sapiens Q6ZU52
Y2H Prey Pooling
32296183
Intra ABI3 Q9P2A4 KIAA0408 Homo sapiens Q6ZU52
Y2H Array
32296183
Intra ABI3 Q9P2A4 SUFU Homo sapiens Q9UMX1
Validated Y2H
32296183
Intra ABI3 Q9P2A4 CEP44 Homo sapiens Q9C0F1
Y2H Array
32296183
Intra ABI3 Q9P2A4 CEP44 Homo sapiens Q9C0F1
Y2H Pooling
16189514
Intra ABI3 Q9P2A4 HOMER3 Homo sapiens Q9NSC5
Y2H Prey Pooling
32296183
Intra ABI3 Q9P2A4 CEP44 Homo sapiens Q9C0F1
Y2H Prey Pooling
32296183
Intra ABI3 Q9P2A4 HOMER3 Homo sapiens Q9NSC5
Y2H Array
32296183
Intra ABI3 Q9P2A4 ARMC7 Homo sapiens Q9H6L4
Validated Y2H
25416956
Intra ABI3 Q9P2A4 ARMC7 Homo sapiens Q9H6L4
Y2H Array
25416956
Intra ABI3 Q9P2A4 HOMER1 Homo sapiens Q86YM7
Y2H Array
32296183
Intra ABI3 Q9P2A4 HOMER1 Homo sapiens Q86YM7
Y2H Pooling
16189514
Intra ABI3 Q9P2A4 HOMER1 Homo sapiens Q86YM7
Y2H Prey Pooling
32296183
Intra ABI3 Q9P2A4 VASP Homo sapiens P50552
Y2H Prey Pooling
32296183
Intra ABI3 Q9P2A4 VASP Homo sapiens P50552
Y2H Array
32296183
Intra ABI3 Q9P2A4 VASP Homo sapiens P50552
Validated Y2H
25416956
Intra ABI3 Q9P2A4 VASP Homo sapiens P50552
Y2H Prey Pooling
25416956
Intra ABI3 Q9P2A4 MRFAP1L1 Homo sapiens Q96HT8
Y2H Prey Pooling
25416956
Intra ABI3 Q9P2A4 MAGEA12 Homo sapiens P43365
Y2H Prey Pooling
25416956
Intra ABI3 Q9P2A4 MAGEA12 Homo sapiens P43365
Validated Y2H
25416956
Intra ABI3 Q9P2A4 IHO1 Homo sapiens Q8IYA8
Y2H Array
32296183
Intra ABI3 Q9P2A4 IHO1 Homo sapiens Q8IYA8
Y2H Prey Pooling
32296183
Intra ABI3 Q9P2A4 IFT20 Homo sapiens Q8IY31-3
Y2H Prey Pooling
32296183
Intra ABI3 Q9P2A4 IFT20 Homo sapiens Q8IY31-3
Y2H Array
32296183
Intra ABI3 Q9P2A4 NDEL1 Homo sapiens Q9GZM8
Y2H Prey Pooling
32296183
Intra ABI3 Q9P2A4 NDEL1 Homo sapiens Q9GZM8
Y2H Array
32296183
Intra ABI3 Q9P2A4 KRT31 Homo sapiens Q15323
Y2H Array
32296183
Intra ABI3 Q9P2A4 KRT31 Homo sapiens Q15323
Y2H Prey Pooling
32296183
Intra ABI3 Q9P2A4 KLC4 Homo sapiens Q9NSK0
Y2H Array
25416956
Intra ABI3 Q9P2A4 KLC4 Homo sapiens Q9NSK0
Y2H Prey Pooling
25416956
Intra ABI3 Q9P2A4 KLC4 Homo sapiens Q9NSK0
Validated Y2H
25416956
Intra ABI3 Q9P2A4 MRFAP1 Homo sapiens Q9Y605
Y2H Prey Pooling
32296183
Intra ABI3 Q9P2A4 MRFAP1 Homo sapiens Q9Y605
Validated Y2H
32296183
Intra ABI3 Q9P2A4 MRFAP1 Homo sapiens Q9Y605
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Polycystic Lipomembranous Osteodysplasia With Sclerosing Leukoencephalopathy 1

Nasu-Hakola Disease

Polycystic Lipomembranous Osteodysplasia With Sclerosing Leukoencephalopathy

Plosl

Nhd

Presenile Dementia With Bone Cysts

Plo-Sl

PLOSL1

Dementia, Prefrontal, With Bone Cysts

Dementia, Progressive, With Lipomembranous Polycystic Osteodysplasia

Brain-Bone-Fat Disease

Progressive Dementia With Lipomembranous Polycystic Osteodysplasia

Brain-Bone-Fat Disease
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS00101 ABI3BP Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS00100 ABI3 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus ABI3 RGD RGD:1311794
Bos taurus ABI3 VGNC VGNC:25507
Mus musculus ABI3 MGD MGI:1913860
Felis catus ABI3 VGNC VGNC:59488
Macaca mulatta ABI3 VGNC VGNC:69549
Canis familiaris ABI3 VGNC VGNC:37476
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