1. Gene
  2. SH3BP1 - SH3 domain binding protein 1 Gene

SH3BP1 - SH3 domain binding protein 1 Gene

中文名称:SH3 结构域结合蛋白 1

种属: Homo sapiens

同用名: ARHGAP43

基因 ID: 23616 | 基因类型: protein coding

关于 SH3BP1

Cytogenetic location: 22q13.1 Genomic coordinates (GRCh38): 22:37,639,669-37,656,117 (from NCBI)

This gene has 10 transcripts (splice variants), 202 orthologues and 2 paralogues. Broad expression in spleen (RPKM 13.4), appendix (RPKM 12.6) and 23 other tissues.

功能概要

该基因编码 Rho GTP 酶激活蛋白 (RhoGAP) 家族的成员。编码的蛋白质调节 Rac 信号,并在细胞骨架动力学、细胞运动和上皮连接形成中发挥作用。这种蛋白质与 exocyst 复合体的结合,将分泌囊泡拴在质膜上,已被证明在细胞运动中很重要。在一个独特的复合物中,这种蛋白质已被证明可以调节上皮连接形成和形态发生。通过与 Plexin-D1 细胞表面受体相互作用,该蛋白介导细胞骨架响应信号蛋白结合而发生的变化。这种蛋白质可能促进人肝癌细胞和组织的转移。[RefSeq 提供,2017 年 3 月]

This gene encodes a member of the Rho GTPase activating protein (RhoGAP) family. The encoded protein regulates Rac signaling and plays a role in cytoskeletal dynamics, cell motility and epithelial junction formation. This protein's association with the exocyst complex, which tethers secretory vesicles to the plasma membrane, has been demonstrated to be important in cell motility. In a distinct complex, this protein has been shown to regulate epithelial junction formation and morphogenesis. By interacting with the Plexin-D1 cell surface receptor, this protein mediates changes in the Cytoskeleton in response to semaphorin binding. This protein may promote metastasis in human liver Cancer cells and tissues. [provided by RefSeq, Mar 2017]

SH3BP1 基因产物(2)

mRNA Protein Name
NM_001350055.2 NP_001336984.1 SH3 domain-binding protein 1 isoform 2
NM_018957.6 NP_061830.3 SH3 domain-binding protein 1 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables GTPase activator activity IMP
IMP: 通过突变表型推断
22891260 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
21044950 GOA
enables semaphorin receptor binding IPI
IPI: 通过物理相互作用推断
24841563 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in actin filament organization IMP
IMP: 通过突变表型推断
22891260 GOA
involved in cell junction assembly IMP
IMP: 通过突变表型推断
22891260 GOA
involved in cell migration IMP
IMP: 通过突变表型推断
21658605 GOA
involved in establishment of epithelial cell apical/basal polarity IMP
IMP: 通过突变表型推断
22891260 GOA
involved in negative regulation of small GTPase mediated signal transduction IMP
IMP: 通过突变表型推断
22891260 GOA
involved in phagocytosis, engulfment IMP
IMP: 通过突变表型推断
26465210 GOA
involved in positive regulation of GTPase activity IMP
IMP: 通过突变表型推断
22891260 GOA
involved in regulation of actin cytoskeleton organization IMP
IMP: 通过突变表型推断
24841563 GOA
involved in regulation of actin filament depolymerization IMP
IMP: 通过突变表型推断
24841563 GOA
involved in regulation of blood vessel endothelial cell migration IMP
IMP: 通过突变表型推断
24841563 GOA
involved in semaphorin-plexin signaling pathway IMP
IMP: 通过突变表型推断
24841563 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in adherens junction IDA
IDA: 通过直接分析推断
22891260 GOA
located in bicellular tight junction IDA
IDA: 通过直接分析推断
22891260 GOA
located in cell leading edge IDA
IDA: 通过直接分析推断
21658605 GOA
located in cytosol IDA
IDA: 通过直接分析推断
22891260 GOA
part of exocyst IDA
IDA: 通过直接分析推断
21658605 GOA
located in lamellipodium IDA
IDA: 通过直接分析推断
24841563 GOA
located in nucleus IDA
IDA: 通过直接分析推断
22891260 GOA
located in phagocytic cup IDA
IDA: 通过直接分析推断
26465210 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

SH3BP1 蛋白结构

BAR

BAR: BAR domain (2 - 252)

RhoGAP

RhoGAP: RhoGAP domain (292 - 438)

  • 0
  • 200
  • 400
  • 600
  • 701 a.a.
蛋白主名 其他名称

SH3 domain-binding protein 1

3BP-1

SH3BP1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
SH3BP1 Q9Y3L3 TRIP10 Homo sapiens Q15642-2
Y2H Prey Pooling
32296183
种属内
SH3BP1 Q9Y3L3 TRIP10 Homo sapiens Q15642-2
Y2H Array
32296183
种属内
SH3BP1 Q9Y3L3 TERF1 Homo sapiens P54274
Pull Down
21044950
种属内
SH3BP1 Q9Y3L3 TERF1 Homo sapiens P54274
BiFC
21044950
种属内
SH3BP1 Q9Y3L3 TRIP10 Homo sapiens Q15642
Validated Y2H
25416956
种属内
SH3BP1 Q9Y3L3 FGA Homo sapiens P02671-2
Y2H Array
32296183
种属内
SH3BP1 Q9Y3L3 FGA Homo sapiens P02671-2
Y2H Prey Pooling
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

直系同源

种属 基因名 来源 基因 ID
Bos taurus SH3BP1 VGNC VGNC:34565
Mus musculus SH3BP1 MGD MGI:104603
Rattus norvegicus SH3BP1 RGD RGD:1306275
Canis familiaris SH3BP1 VGNC VGNC:46117