2. Gene
  3. EVL - Enah/Vasp-like Gene

EVL - Enah/Vasp-like Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：Enah/Vasp-like

种属: Homo sapiens

同用名: RNB6

基因 ID: 51466 | 基因类型: protein coding

关于 EVL

Cytogenetic location: 14q32.2 Genomic coordinates (GRCh38): 14:99,971,422-100,144,236 (from NCBI)

This gene has 24 transcripts (splice variants), 264 orthologues and 5 paralogues. Broad expression in lymph node (RPKM 31.5), spleen (RPKM 27.6) and 24 other tissues.

功能概要

预测启用 SH3 域绑定活动和概要文件绑定活动。参与上皮细胞迁移的负调控；荷叶边组件的负调节；和应力纤维组装的正向调节。位于膜内。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable SH3 domain binding activity and profilin binding activity. Involved in negative regulation of epithelial cell migration; negative regulation of ruffle assembly; and positive regulation of stress fiber assembly. Located in membrane. [provided by Alliance of Genome Resources, Apr 2022]

EVL 基因产物(2)

mRNA Protein Name
NM_001330221.2 NP_001317150.1 ena/VASP-like protein isoform 2
NM_016337.3 NP_057421.1 ena/VASP-like protein isoform 1
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
10993894 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of epithelial cell migration IMP
IMP: 通过突变表型推断
23153535 GOA
involved in negative regulation of ruffle assembly IMP
IMP: 通过突变表型推断
23153535 GOA
involved in positive regulation of stress fiber assembly IMP
IMP: 通过突变表型推断
23153535 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

EVL 蛋白结构

WH1

WH1: WH1 domain (4 - 105)

VASP_tetra

VASP_tetra: VASP tetramerisation domain (376 - 415)

  • 0
  • 100
  • 200
  • 300
  • 416 a.a.
蛋白主名 其他名称

ena/VASP-like protein

ena/vasodilator-stimulated phosphoprotein-like

EVL 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
EVL Q9UI08 SPTAN1 Homo sapiens Q13813
Anti Tag CoIP
16336193
种属内
EVL Q9UI08 SPTAN1 Homo sapiens Q13813
Y2H
16336193
种属内
EVL Q9UI08 TRIM9 Homo sapiens Q9C026
Validated Y2H
25416956
种属内
EVL Q9UI08 ABI3 Homo sapiens Q9P2A4
Y2H Array
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Gastrointestinal Adenoma

Gi Adenoma

Digestive System Adenoma
Myasthenic Syndrome, Congenital, 10

Congenital Myasthenic Syndrome 10

CMS10

Lgm

Myasthenia, Limb-Girdle, Familial

Myasthenia, Limb-Girdle, Familial, Formerly

Lgm, Formerly

Congenital Myasthenic Syndrome Type Ib, Formerly

Cms1b, Formerly

Cms Ib, Formerly

Myasthenic Myopathy, Formerly

Familial Limb-Girdle Myasthenia

Cms1b

Cms Ib

Congenital Myasthenic Syndrome Type 1b

Congenital Myasthenic Syndrome Type Ib

Myasthenic Myopathy

Myasthenic Syndrome, Congenital, Type 10

Congenital Myasthenic Syndrome Ib

Myopathy In Myasthenia Gravis
Drug-Induced Lupus Erythematosus

Dile

Dil

Drug-Induced Systemic Lupus Erythematosus
Frontometaphyseal Dysplasia

Fmd

Dysplasia, Frontometaphyseal
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS04577 EVL Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus EVL RGD RGD:621150
Bos taurus EVL VGNC VGNC:28636
Canis familiaris EVL VGNC VGNC:40505
Felis catus EVL VGNC VGNC:61991
Mus musculus EVL MGD MGI:1194884
Macaca mulatta EVL VGNC VGNC:72306
Others EVL NCBI
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