2. Gene
  3. RUFY3 - RUN and FYVE domain containing 3 Gene

RUFY3 - RUN and FYVE domain containing 3 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：含 RUN 和 FYVE 结构域 3

种属: Homo sapiens

同用名: RIPX; SINGAR1; ZFYVE30

基因 ID: 22902 | 基因类型: protein coding

关于 RUFY3

Cytogenetic location: 4q13.3 Genomic coordinates (GRCh38): 4:70,703,767-70,808,619 (from NCBI)

This gene has 15 transcripts (splice variants), 215 orthologues and 13 paralogues. Ubiquitous expression in brain (RPKM 27.2), testis (RPKM 10.8) and 24 other tissues.

功能概要

该基因编码一个包含 RPIP8、UNC-14 和 NESCA 结构域的蛋白质，这是维持神经元极性所必需的。此外，它通过与促进其表达的 P21 激活激酶-1 相互作用，参与胃癌细胞迁移和侵袭的介导。编码的蛋白质定位于富含 F-肌动蛋白的侵袭伪足以诱导突起的形成，从而促进细胞迁移。可变剪接导致多个转录本变体。[RefSeq 提供，2016 年 9 月]

This gene encodes a RPIP8, UNC-14, and NESCA domain-containing protein that is required for maintenance of neuronal polarity. In addition, it has been implicated in mediation of gastric Cancer cell migration and invasion via interaction with P21-activated kinase-1, which promotes its expression. The encoded protein localizes to F-actin-enriched invadopodia to induce formation of protrusions, thereby facilitating cell migration. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]

RUFY3 基因产物(6)

mRNA Protein Name
NM_001037442.4 NP_001032519.1 protein RUFY3 isoform 1
NM_001130709.2 NP_001124181.1 protein RUFY3 isoform 3
NM_001291993.2 NP_001278922.1 protein RUFY3 isoform 4
NM_001291994.2 NP_001278923.1 protein RUFY3 isoform 5
NM_001345840.2 NP_001332769.1 protein RUFY3 isoform 6
NM_014961.5 NP_055776.1 protein RUFY3 isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
25766321 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in positive regulation of cell migration IDA
IDA: 通过直接分析推断
25766321 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
25766321 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

RUFY3 蛋白结构

RUN

RUN: RUN domain (103 - 225)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 469 a.a.
蛋白主名 其他名称

protein RUFY3

rap2 interacting protein x

RUFY3 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
RUFY3 Q7L099 ABI3 Homo sapiens Q9P2A4
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Gastric Cancer

Stomach Cancer

Gastric Carcinoma

Stomach Carcinoma

Gastric Cancer, Somatic

Gastric Neoplasm

Carcinoma Of Stomach

Stomach Neoplasms

Malignant Neoplasm Of Stomach

Gastric Cancer Risk After H. Pylori Infection

Cancer Of The Stomach

Adult Stomach Cancer

Adult Stomach Carcinoma

GASC

Gastric Cancer Intestinal

Gastric Cancers

Gastric Carcinomas

Cancer, Gastric

Stomach Neoplasm

Malignant Neoplasm Of Body Of Stomach

Malignant Tumor Of Lesser Curve Of Stomach

Gastrocarcinoma Of Unspecified Site

Leather Bottle Stomach

Carcinoma Of Fundus Of Stomach

Cancer Of Fundus Of Stomach

Primary Malignant Neoplasm Of Body Of Stomach

Cancer Of Body Of Stomach

Primary Malignant Neoplasm Of Pyloric Antrum

Pyloric Antrum Cancer

Malignant Tumour Of Stomach
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS12345 RUFY3 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris RUFY3 VGNC VGNC:45805
Macaca mulatta RUFY3 VGNC VGNC:77128
Bos taurus RUFY3 VGNC VGNC:34215
Rattus norvegicus RUFY3 RGD RGD:1565242
Mus musculus RUFY3 MGD MGI:106484
Felis catus RUFY3 VGNC VGNC:64820
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z