VASP - vasodilator stimulated phosphoprotein Gene

中文名称：血管扩张因子刺激的磷蛋白

种属: Homo sapiens

关于 VASP

功能概要

血管扩张剂刺激的磷蛋白 (VASP) 是 Ena-VASP 蛋白家族的成员。 Ena-VASP 家族成员包含一个 EHV1 N 末端结构域，该结构域结合含有 E/DFPPPPXD/E 基序的蛋白质，并将 Ena-VASP 蛋白质靶向粘着斑。在蛋白质的中部区域，家族成员有一个富含脯氨酸的结构域，该结构域结合包含 SH3 和 WW 结构域的蛋白质。它们的 C 端 EVH2 结构域介导四聚化并结合 G 和 F 肌动蛋白。 VASP 与丝状肌动蛋白形成有关，可能在细胞粘附和运动中起着广泛的作用。 VASP 也可能参与调节整合素-细胞外基质相互作用的细胞内信号通路。 VASP 受环核苷酸依赖性激酶 PKA 和 PKG 的调节。[RefSeq 提供，2008 年 7 月]

Vasodilator-stimulated phosphoprotein (VASP) is a member of the Ena-VASP protein family. Ena-VASP family members contain an EHV1 N-terminal domain that binds proteins containing E/DFPPPPXD/E motifs and targets Ena-VASP proteins to focal adhesions. In the mid-region of the protein, family members have a proline-rich domain that binds SH3 and WW domain-containing proteins. Their C-terminal EVH2 domain mediates tetramerization and binds both G and F actin. VASP is associated with filamentous actin formation and likely plays a widespread role in cell adhesion and motility. VASP may also be involved in the intracellular signaling pathways that regulate integrin-extracellular matrix interactions. VASP is regulated by the cyclic nucleotide-dependent kinases PKA and PKG. [provided by RefSeq, Jul 2008]