2. Gene
  3. RPS6KA1 - ribosomal protein S6 kinase A1 Gene

RPS6KA1 - ribosomal protein S6 kinase A1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：核糖体蛋白 S6 激酶 A1

种属: Homo sapiens

同用名: RSK; HU-1; RSK1; p90Rsk; MAPKAPK1; MAPKAPK1A

基因 ID: 6195 | 基因类型: protein coding

关于 RPS6KA1

Cytogenetic location: 1p36.11 Genomic coordinates (GRCh38): 1:26,529,761-26,575,025 (from NCBI)

This gene has 20 transcripts (splice variants), 1 gene allele, 218 orthologues and 7 paralogues. Broad expression in small intestine (RPKM 31.6), duodenum (RPKM 29.3) and 21 other tissues.

功能概要

该基因编码丝氨酸/苏氨酸激酶 RSK (核糖体 S6 激酶) 家族的成员。该激酶包含 2 个不同的激酶催化结构域并磷酸化各种底物，包括有丝分裂原活化激酶 (MAPK) 信号通路的成员。这种蛋白质的活性与控制细胞生长和分化有关。已经表征了编码不同亚型的替代转录剪接变体。[RefSeq 提供，2008 年 7 月]

This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 nonidentical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

RPS6KA1 基因产物(5)

mRNA Protein Name
XM_024448871.2 XP_024304639.1 ribosomal protein S6 kinase alpha-1 isoform X2
XM_047427258.1 XP_047283214.1 ribosomal protein S6 kinase alpha-1 isoform X1
NM_001330441.2 NP_001317370.1 ribosomal protein S6 kinase alpha-1 isoform c
NM_002953.4 NP_002944.2 ribosomal protein S6 kinase alpha-1 isoform a
NM_001006665.2 NP_001006666.1 ribosomal protein S6 kinase alpha-1 isoform b

RPS6KA1 蛋白结构

Pkinase

Pkinase: Protein kinase domain (62 - 319)

Pkinase_C

Pkinase_C: Protein kinase C terminal domain (343 - 383)

Pkinase

Pkinase: Protein kinase domain (418 - 675)

  • 0
  • 200
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  • 600
  • 735 a.a.
蛋白主名 其他名称

ribosomal protein S6 kinase alpha-1

90 kDa ribosomal protein S6 kinase 1

MAP kinase-activated protein kinase 1a

MAPK-activated protein kinase 1a

MAPKAP kinase 1a

MAPKAPK-1a

RSK-1

S6K-alpha 1

dJ590P13.1 (ribosomal protein S6 kinase, 90kD, polypeptide 1)

p90-RSK 1

p90RSK1

p90S6K

ribosomal S6 kinase 1

ribosomal protein S6 kinase, 90kDa, polypeptide 1

关联疾病

疾病名称 别名
Sarcoma

Connective And Soft Tissue Neoplasm

Tumor Of Soft Tissue And Skeleton

Sarcomas

Sarcoma - Category
Tuberous Sclerosis

Tuberous Sclerosis Syndrome

Bourneville'S Disease

Epiloia

Cerebral Sclerosis

Tuberose Sclerosis

Tuberous Sclerosis 1

Bourneville Disease

Bourneville Phakomatosis

Pringle'S Disease
Coffin-Lowry Syndrome

CLS

Mental Retardation With Osteocartilaginous Abnormalities

Coffin Syndrome 1

Coffin Syndrome

Dwarfism, Lean Spastic Type

Lean Spastic Dwarfism

Coffin Lowry Syndrome
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (9)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-123919 TL13-112 Inhibitor 98.15% 否
HY-148063 DB0614 98.80% 否
HY-122582 TL13-12 Inhibitor 98.06% 否
HY-148061 DB1113 99.28% 否
HY-136194 TL13-22 Inhibitor / 否
HY-136195 TL13-110 Inhibitor / 否
HY-RS12248 RPS6KA1 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS12249 Rps6ka1 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS12250 Rps6ka1 Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris RPS6KA1 VGNC VGNC:45738
Macaca mulatta RPS6KA1 VGNC VGNC:76927
Rattus norvegicus RPS6KA1 RGD RGD:620675
Felis catus RPS6KA1 VGNC VGNC:64754
Bos taurus RPS6KA1 VGNC VGNC:34140
Mus musculus RPS6KA1 MGD MGI:104558
Others RPS6KA1 NCBI
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