1. Gene
  2. RPS6KA1 - ribosomal protein S6 kinase A1 Gene

RPS6KA1 - ribosomal protein S6 kinase A1 Gene

中文名称:核糖体蛋白 S6 激酶 A1

种属: Homo sapiens

同用名: RSK; HU-1; RSK1; p90Rsk; MAPKAPK1; MAPKAPK1A

基因 ID: 6195 | 基因类型: protein coding

关于 RPS6KA1

Cytogenetic location: 1p36.11 Genomic coordinates (GRCh38): 1:26,529,761-26,575,025 (from NCBI)

This gene has 20 transcripts (splice variants), 1 gene allele, 218 orthologues and 7 paralogues. Broad expression in small intestine (RPKM 31.6), duodenum (RPKM 29.3) and 21 other tissues.

功能概要

该基因编码丝氨酸/苏氨酸激酶 RSK (核糖体 S6 激酶) 家族的成员。该激酶包含 2 个不同的激酶催化结构域并磷酸化各种底物,包括有丝分裂原活化激酶 (MAPK) 信号通路的成员。这种蛋白质的活性与控制细胞生长和分化有关。已经表征了编码不同亚型的替代转录剪接变体。[RefSeq 提供,2008 年 7 月]

This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 nonidentical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

RPS6KA1 基因产物(5)

mRNA Protein Name
XM_024448871.2 XP_024304639.1 ribosomal protein S6 kinase alpha-1 isoform X2
XM_047427258.1 XP_047283214.1 ribosomal protein S6 kinase alpha-1 isoform X1
NM_001330441.2 NP_001317370.1 ribosomal protein S6 kinase alpha-1 isoform c
NM_002953.4 NP_002944.2 ribosomal protein S6 kinase alpha-1 isoform a
NM_001006665.2 NP_001006666.1 ribosomal protein S6 kinase alpha-1 isoform b
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process IDA
IDA: 通过直接分析推断
18402937 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
19470470 GOA
enables protein serine/threonine kinase activity IDA
IDA: 通过直接分析推断
10679322 GOA
enables protein serine/threonine/tyrosine kinase activity IDA
IDA: 通过直接分析推断
22797923 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of TOR signaling IMP
IMP: 通过突变表型推断
35772404 GOA
involved in negative regulation of apoptotic process IDA
IDA: 通过直接分析推断
18402937 GOA
involved in negative regulation of apoptotic process IMP
IMP: 通过突变表型推断
11684016 GOA
involved in positive regulation of hepatic stellate cell activation IMP
IMP: 通过突变表型推断
10679322 GOA
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
22065586 GOA
involved in protein phosphorylation IMP
IMP: 通过突变表型推断
35772404 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

RPS6KA1 蛋白结构

Pkinase

Pkinase: Protein kinase domain (62 - 319)

Pkinase_C

Pkinase_C: Protein kinase C terminal domain (343 - 383)

Pkinase

Pkinase: Protein kinase domain (418 - 675)

  • 0
  • 200
  • 400
  • 600
  • 735 a.a.
蛋白主名 其他名称

ribosomal protein S6 kinase alpha-1

90 kDa ribosomal protein S6 kinase 1

MAP kinase-activated protein kinase 1a

MAPK-activated protein kinase 1a

MAPKAP kinase 1a

MAPKAPK-1a

RSK-1

S6K-alpha 1

dJ590P13.1 (ribosomal protein S6 kinase, 90kD, polypeptide 1)

p90-RSK 1

p90RSK1

p90S6K

ribosomal S6 kinase 1

ribosomal protein S6 kinase, 90kDa, polypeptide 1

RPS6KA1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
RPS6KA1 Q15418 CDC37 Homo sapiens Q16543 35271311
种属内
RPS6KA1 Q15418 CDC37 Homo sapiens Q16543 31980649
种属内
RPS6KA1 Q15418 HSP90AB1 Homo sapiens P08238 31980649
种属内
RPS6KA1 Q15418 HSP90AB1 Homo sapiens P08238
TAP
23455922
种属内
RPS6KA1 Q15418 SCRIB Homo sapiens Q14160 30126976
种属内
RPS6KA1 Q15418 S100B Homo sapiens P04271
FPS
31837246
种属内
RPS6KA1 Q15418 VASP Homo sapiens P50552 21423205
种属内
RPS6KA1 Q15418 VASP Homo sapiens P50552 21423205
种属内
RPS6KA1 Q15418 MAPK1 Homo sapiens P28482
TAP
23455922
种属内
RPS6KA1 Q15418 MAPK1 Homo sapiens P28482 23519423
种属间
RPS6KA1 Q15418 yopM Yersinia enterocolitica serotype O:8/biotype 1B A1JU68 25513777
种属间: 跨种属相互作用 种属内: 同种属相互作用

RPS6KA1 抗体

目录号 产品名 应用 反应物种
HY-P80848 Phospho-RSK1 p90 (Ser380) Antibody WB, ICC/IF, IP Human, Rat, Mouse
HY-P80849 Phospho-RSK1 p90 (Thr359/Ser363) Antibody WB, IP Human, Mouse, Rat
HY-P80886 RSK1 p90 Antibody (YA676) WB, IP Human, Mouse, Monkey

关联疾病

疾病名称 别名
Sarcoma

Connective And Soft Tissue Neoplasm

Tumor Of Soft Tissue And Skeleton

Sarcomas

Sarcoma - Category

Tuberous Sclerosis

Tuberous Sclerosis Syndrome

Bourneville'S Disease

Epiloia

Cerebral Sclerosis

Tuberose Sclerosis

Tuberous Sclerosis 1

Bourneville Disease

Bourneville Phakomatosis

Pringle'S Disease

Coffin-Lowry Syndrome

CLS

Mental Retardation With Osteocartilaginous Abnormalities

Coffin Syndrome 1

Coffin Syndrome

Dwarfism, Lean Spastic Type

Lean Spastic Dwarfism

Coffin Lowry Syndrome

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Canis familiaris RPS6KA1 VGNC VGNC:45738
Macaca mulatta RPS6KA1 VGNC VGNC:76927
Rattus norvegicus RPS6KA1 RGD RGD:620675
Felis catus RPS6KA1 VGNC VGNC:64754
Bos taurus RPS6KA1 VGNC VGNC:34140
Mus musculus RPS6KA1 MGD MGI:104558
Others RPS6KA1 NCBI