2. Gene
  3. NSMAF - neutral sphingomyelinase activation associated factor Gene

NSMAF - neutral sphingomyelinase activation associated factor Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：中性鞘磷脂酶激活相关因子

种属: Homo sapiens

同用名: FAN; GRAMD5

基因 ID: 8439 | 基因类型: protein coding

关于 NSMAF

Cytogenetic location: 8q12.1 Genomic coordinates (GRCh38): 8:58,583,504-58,659,853 (from NCBI)

This gene has 18 transcripts (splice variants), 217 orthologues and 7 paralogues. Ubiquitous expression in lymph node (RPKM 12.0), appendix (RPKM 10.7) and 25 other tissues.

功能概要

该基因编码一种 WD 重复蛋白，该蛋白结合 55kD 肿瘤坏死因子受体的细胞质鞘磷脂酶激活域。这种蛋白质是 TNF 介导的中性鞘磷脂酶激活所必需的，并且可能在调节 TNF 诱导的细胞反应 (例如炎症) 中发挥作用。可变剪接导致多个转录变体。[RefSeq 提供，2009 年 1 月]

This gene encodes a WD-repeat protein that binds the cytoplasmic sphingomyelinase activation domain of the 55kD tumor necrosis factor receptor. This protein is required for TNF-mediated activation of neutral sphingomyelinase and may play a role in regulating TNF-induced cellular responses such as inflammation. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jan 2009]

NSMAF 基因产物(24)

mRNA Protein Name
NM_001144772.1 NP_001138244.1 protein FAN isoform 2
NM_001412988.1 NP_001399917.1 protein FAN isoform 3
NM_001412989.1 NP_001399918.1 protein FAN isoform 4
NM_001412990.1 NP_001399919.1 protein FAN isoform 5
NM_001412991.1 NP_001399920.1 protein FAN isoform 6
NM_001412992.1 NP_001399921.1 protein FAN isoform 7
NM_001412993.1 NP_001399922.1 protein FAN isoform 8
NM_001412994.1 NP_001399923.1 protein FAN isoform 9
NM_001412995.1 NP_001399924.1 protein FAN isoform 10
NM_001412996.1 NP_001399925.1 protein FAN isoform 6
NM_001412997.1 NP_001399926.1 protein FAN isoform 6
NM_001412998.1 NP_001399927.1 protein FAN isoform 11
NM_001412999.1 NP_001399928.1 protein FAN isoform 6
NM_001413000.1 NP_001399929.1 protein FAN isoform 6
NM_001413001.1 NP_001399930.1 protein FAN isoform 6
NM_001413002.1 NP_001399931.1 protein FAN isoform 12
NM_001413003.1 NP_001399932.1 protein FAN isoform 6
NM_001413004.1 NP_001399933.1 protein FAN isoform 6
NM_001413005.1 NP_001399934.1 protein FAN isoform 9
NM_001413006.1 NP_001399935.1 protein FAN isoform 13
NM_001413007.1 NP_001399936.1 protein FAN isoform 14
NM_001413008.1 NP_001399937.1 protein FAN isoform 14
NM_001413009.1 NP_001399938.1 protein FAN isoform 15
NM_003580.4 NP_003571.2 protein FAN isoform 1

NSMAF 蛋白结构

GRAM

GRAM: GRAM domain (180 - 246)

Beach

Beach: Beige/BEACH domain (303 - 575)

WD40

WD40: WD domain, G-beta repeat (709 - 740)

WD40

WD40: WD domain, G-beta repeat (799 - 832)

WD40

WD40: WD domain, G-beta repeat (882 - 914)

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  • 917 a.a.
蛋白主名 其他名称

protein FAN

factor associated with N-SMase activation

NSMAF 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
NSMAF Q92636 ACTB Homo sapiens P60709
Pull Down
17599063
种属内
NSMAF Q92636 DCP1B Homo sapiens Q8IZD4
Pull Down
26133670
种属内
NSMAF Q92636 GABARAP Homo sapiens O95166
Pull Down
20562859
种属内
NSMAF Q92636 GABARAPL1 Homo sapiens Q9H0R8
Anti Tag CoIP
33961781
种属内
NSMAF Q92636 GABARAPL1 Homo sapiens Q9H0R8
Anti Tag CoIP
28514442
种属内
NSMAF Q92636 GABARAPL1 Homo sapiens Q9H0R8
Pull Down
20562859
种属内
NSMAF Q92636 VASP Homo sapiens P50552
Pull Down
17599063
种属间
NSMAF Q92636 dcp1_arath Arabidopsis thaliana Q9SJF3
Y2H
26133670
种属间
NSMAF Q92636 dcp1_arath Arabidopsis thaliana Q9SJF3
Pull Down
26133670
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS09596 NSMAF Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus NSMAF VGNC VGNC:32278
Mus musculus NSMAF MGD MGI:1341864
Felis catus NSMAF VGNC VGNC:68573
Rattus norvegicus NSMAF RGD RGD:727868
Canis familiaris NSMAF VGNC VGNC:43987
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