2. Gene
  3. KRT24 - keratin 24 Gene

KRT24 - keratin 24 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：角蛋白 24

种属: Homo sapiens

同用名: K24; KA24; CK-24

基因 ID: 192666 | 基因类型: protein coding

关于 KRT24

Cytogenetic location: 17q21.2 Genomic coordinates (GRCh38): 17:40,694,246-40,703,752 (from NCBI)

This gene has 1 transcript (splice variant), 114 orthologues and 68 paralogues. Biased expression in esophagus (RPKM 10.1), colon (RPKM 5.1) and 2 other tissues.

功能概要

该基因编码 I 型 (酸性) 角蛋白家族的成员，属于中间丝 (IF) 蛋白超家族。角蛋白是形成中间丝的杂聚结构蛋白。这些细丝与肌动蛋白微丝和微管一起构成了上皮细胞的细胞骨架。 I 型角蛋白基因聚集在染色体 17q12-q21 的区域。[RefSeq 提供，2009 年 6 月]

This gene encodes a member of the type I (acidic) keratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the Cytoskeleton of epithelial cells. The type I keratin genes are clustered in a region of chromosome 17q12-q21. [provided by RefSeq, Jun 2009]

KRT24 基因产物(1)

mRNA Protein Name
NM_019016.3 NP_061889.2 keratin, type I cytoskeletal 24
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

KRT24 蛋白结构

Filament

Filament: Intermediate filament protein (140 - 452)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 525 a.a.
蛋白主名 其他名称

keratin, type I cytoskeletal 24

cytokeratin-24

KRT24 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra KRT24 Q2M2I5 CCHCR1 Homo sapiens Q8TD31-3
Validated Y2H
32296183
Intra KRT24 Q2M2I5 TSGA10IP Homo sapiens Q3SY00
Validated Y2H
32296183
Intra KRT24 Q2M2I5 CCDC146 Homo sapiens Q8IYE0
Validated Y2H
32296183
Intra KRT24 Q2M2I5 TRIML2 Homo sapiens Q8N7C3
Validated Y2H
32296183
Intra KRT24 Q2M2I5 ABI2 Homo sapiens Q9NYB9-2
Validated Y2H
32296183
Intra KRT24 Q2M2I5 KRT80 Homo sapiens Q6KB66-2
Validated Y2H
32296183
Intra KRT24 Q2M2I5 RCOR3 Homo sapiens Q9P2K3-2
Validated Y2H
32296183
Intra KRT24 Q2M2I5 KRT79 Homo sapiens Q5XKE5
Validated Y2H
32296183
Intra KRT24 Q2M2I5 KRT71 Homo sapiens Q3SY84
Validated Y2H
32296183
Intra KRT24 Q2M2I5 AARD Homo sapiens Q4LEZ3
Validated Y2H
32296183
Intra KRT24 Q2M2I5 TCHP Homo sapiens Q9BT92
Validated Y2H
32296183
Intra KRT24 Q2M2I5 ABI3 Homo sapiens Q9P2A4
Validated Y2H
32296183
Intra KRT24 Q2M2I5 SGF29 Homo sapiens Q96ES7
Validated Y2H
32296183
Intra KRT24 Q2M2I5 C1orf216 Homo sapiens Q8TAB5
Validated Y2H
32296183
Intra KRT24 Q2M2I5 AIRIM Homo sapiens Q9NX04
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Naegeli-Franceschetti-Jadassohn Syndrome

Naegeli Syndrome

Nfj Syndrome

NFJS

Reticular Skin Changes, Dental Anomalies, Decreased Function Of Sweat Glands, Strabismus, And Optic Atrophy

Naegeli-Franceschetti-Jadassohn Syndrome/Dermatopathia Pigmentosa Reticularis

Dpr

Franceschetti-Jadassohn Syndrome

Nfjs/Dpr
Retinitis Pigmentosa 42

RP42

Retinitis Pigmentosa-42

Retinitis Pigmentosa, Type 42
Dermatopathia Pigmentosa Reticularis

DPR
Ectodermal Dysplasia 4, Hair/Nail Type

Pure Hair And Nail Ectodermal Dysplasia

ECTD4

Ectodermal Dysplasia, Pure Hair-Nail Type

Ectodermal Dysplasia, 'Pure' Hair/Nail Type

Hned

Hair-Nail Ectodermal Dysplasia

Phned

Ectodermal Dysplasia Pure Hair-Nail Type

Ectodermal Dysplasia, 'Pure' Hair-Nail Type

Dysplasia, Ectodermal, Type 4, Hair/Nail
Brill-Zinsser Disease

Recrudescent Typhus

Brill Disease

Brill Zinsser Disease

Brill'S Disease

Latent Typhus

Sporadic Typhus

Typhus, Epidemic Louse-Borne

Recrudescent Typhus Due To Rickettsia Prowazekii

Recrudescent Typhus Fever

Recrudescent Brill-Zinsser Typhus Due To Rickettsia Prowazekii

Recrudescent Brill Disease

Recrudescent Typhus Fever Due To Rickettsia Prowazekii
Autosomal Dominant Severe Congenital Neutropenia

Severe Congenital Neutropenia Autosomal Dominant

Neutropenia, Congenital, Severe, Autosomal Dominant
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS07448 KRT24 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus KRT24 RGD RGD:1303157
Canis familiaris KRT24 VGNC VGNC:42523
Felis catus KRT24 VGNC VGNC:63170
Mus musculus KRT24 MGD MGI:1922956
Bos taurus KRT24 VGNC VGNC:30723
Macaca mulatta KRT24 VGNC VGNC:99164
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