2. Gene
  3. FARSA - phenylalanyl-tRNA synthetase subunit alpha Gene

FARSA - phenylalanyl-tRNA synthetase subunit alpha Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：苯丙氨酰-tRNA 合成酶亚基α

种属: Homo sapiens

同用名: FRSA; CML33; FARSL; PheHA; FARSLA; RILDBC2

基因 ID: 2193 | 基因类型: protein coding

关于 FARSA

Cytogenetic location: 19p13.13 Genomic coordinates (GRCh38): 19:12,922,479-12,933,711 (from NCBI)

This gene has 10 transcripts (splice variants), 199 orthologues, 2 paralogues and is associated with 1 phenotype. Ubiquitous expression in brain (RPKM 24.2), lymph node (RPKM 16.8) and 25 other tissues.

功能概要

氨酰-tRNA 合成酶是一类用同源氨基酸给 tRNA 充电的酶。该基因编码的产物类似于原核生物和酿酒酵母苯丙氨酰-tRNA 合成酶 (PheRS) 的催化亚基。该基因产物已被证明以肿瘤选择性和细胞周期阶段和分化依赖的方式表达，tRNA 合成酶基因家族的第一个成员显示出这种类型的调节表达[RefSeq 提供，2008 年 7 月]

Aminoacyl-tRNA synthetases are a class of Enzymes that charge tRNAs with their cognate Amino acids. This gene encodes a product which is similar to the catalytic subunit of prokaryotic and Saccharomyces cerevisiae phenylalanyl-tRNA synthetases (PheRS). This gene product has been shown to be expressed in a tumor-selective and cell cycle stage- and differentiation-dependent manner, the first member of the tRNA synthetase gene family shown to exhibit this type of regulated expression [provided by RefSeq, Jul 2008]

FARSA 基因产物(1)

mRNA Protein Name
NM_004461.3 NP_004452.1 phenylalanine--tRNA ligase alpha subunit
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables phenylalanine-tRNA ligase activity IDA
IDA: 通过直接分析推断
20223217 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
20223217 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in phenylalanyl-tRNA aminoacylation IDA
IDA: 通过直接分析推断
20223217 GOA
involved in protein heterotetramerization IDA
IDA: 通过直接分析推断
20223217 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of phenylalanine-tRNA ligase complex IDA
IDA: 通过直接分析推断
20223217 GOA
part of phenylalanine-tRNA ligase complex IPI
IPI: 通过物理相互作用推断
20223217 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

FARSA 蛋白结构

tRNA-synt_2d

tRNA-synt_2d: tRNA synthetases class II core domain (F) (210 - 483)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 508 a.a.
蛋白主名 其他名称

phenylalanine--tRNA ligase alpha subunit

pheRS

FARSA 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra FARSA Q9Y285 FARSB Homo sapiens Q9NSD9
Anti Tag CoIP
33961781
Intra FARSA Q9Y285 FARSB Homo sapiens Q9NSD9
Pull Down
20223217
Intra FARSA Q9Y285 FARSB Homo sapiens Q9NSD9
Y2H Prey Pooling
32296183
Intra FARSA Q9Y285 FARSB Homo sapiens Q9NSD9
GMS
20223217
Intra FARSA Q9Y285 FARSB Homo sapiens Q9NSD9
X-Ray Diffraction
20223217
Intra FARSA Q9Y285 FARSB Homo sapiens Q9NSD9
Y2H Array
32296183
Intra FARSA Q9Y285 FARSB Homo sapiens Q9NSD9
Anti Tag CoIP
28514442
Intra FARSA Q9Y285 COG4 Homo sapiens Q9H9E3
Y2H Prey Pooling
32296183
Intra FARSA Q9Y285 COG4 Homo sapiens Q9H9E3
Y2H Array
32296183
Intra FARSA Q9Y285 ECSIT Homo sapiens Q9BQ95
Pull Down
21163940
Intra FARSA Q9Y285 PDCD10 Homo sapiens Q9BUL8
Y2H Prey Pooling
32296183
Intra FARSA Q9Y285 PDCD10 Homo sapiens Q9BUL8
Y2H Array
32296183
Intra FARSA Q9Y285 ABI3 Homo sapiens Q9P2A4
Y2H Prey Pooling
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Rajab Interstitial Lung Disease With Brain Calcifications 2

RILDBC2
Interstitial Lung Disease

Ild

Lung Diseases, Interstitial

Lung Diseases Interstitial

Interstitial Lung Diseases
Liver Disease

Liver Failure

Liver Diseases

Abnormality Of The Liver

Liver Dysfunction

Disorder Of Liver

Hepatic Disorder

Hepatic Disease

Disease Of Bilirubin Metabolism

Disorder Of Bilirubin Metabolism

Liver Decompensation

Liver Function Failure

Hepatic Failure Nos

Liver Failure Nos

End Stage Liver Disease

Decompensated Liver Failure

Decompensation Of Liver Function

Hepatic Decompensation

Hepatic Insufficiency

Liver Cell Necrosis With Hepatic Failure

Liver Insufficiency

Decompensated Liver Disease

End Stage Liver Failure

Liver Necrosis With Hepatic Failure
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS04749 FARSA Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus FARSA RGD RGD:1310314
Macaca mulatta FARSA VGNC VGNC:72615
Felis catus FARSA VGNC VGNC:62151
Mus musculus FARSA MGD MGI:1913840
Bos taurus FARSA VGNC VGNC:28867
Canis familiaris FARSA VGNC VGNC:40733
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