1. Gene
  2. NDEL1 - nudE neurodevelopment protein 1 like 1 Gene

NDEL1 - nudE neurodevelopment protein 1 like 1 Gene

中文名称:nudE 神经发育蛋白 1 样 1

种属: Homo sapiens

同用名: EOPA; NDE2; NUDEL; MITAP1; NDE1L1

基因 ID: 81565 | 基因类型: protein coding

关于 NDEL1

Cytogenetic location: 17p13.1 Genomic coordinates (GRCh38): 17:8,413,131-8,474,328 (from NCBI)

This gene has 19 transcripts (splice variants), 96 orthologues and 1 paralogue. Ubiquitous expression in bone marrow (RPKM 18.6), adrenal (RPKM 13.4) and 25 other tissues.

功能概要

该基因编码一种卷曲螺旋蛋白,该蛋白在多个过程中发挥作用,包括细胞骨架组织、细胞信号传导和神经元迁移、生长和维持。已经观察到该基因编码多种同种型的选择性剪接转录变体,并且该基因的假基因位于染色体 X 的长臂上。[RefSeq 提供,2012 年 3 月]

This gene encodes a coiled-coil protein that plays a role in multiple processes including cytoskeletal organization, cell signaling and neuron migration, outgrowth and maintenance. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome X. [provided by RefSeq, Mar 2012]

NDEL1 基因产物(3)

mRNA Protein Name
NM_001025579.3 NP_001020750.1 nuclear distribution protein nudE-like 1 isoform A
NM_001330129.2 NP_001317058.1 nuclear distribution protein nudE-like 1 isoform C
NM_030808.5 NP_110435.1 nuclear distribution protein nudE-like 1 isoform B
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables identical protein binding IPI
IPI: 通过物理相互作用推断
10931877 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
10931877 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in chromosome segregation IMP
IMP: 通过突变表型推断
17600710 GOA
involved in positive regulation of GTPase activity IMP
IMP: 通过突变表型推断
21283621 GOA
involved in regulation of intracellular protein transport IMP
IMP: 通过突变表型推断
21283621 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in kinetochore IDA
IDA: 通过直接分析推断
17600710 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

NDEL1 蛋白结构

NUDE_C

NUDE_C: NUDE protein, C-terminal conserved region (135 - 336)

  • 0
  • 100
  • 200
  • 300
  • 345 a.a.
蛋白主名 其他名称

nuclear distribution protein nudE-like 1

endooligopeptidase A

NDEL1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
NDEL1 Q9GZM8 KRT40 Homo sapiens Q6A162 25416956
种属内
NDEL1 Q9GZM8 KRT40 Homo sapiens Q6A162 25416956
种属内
NDEL1 Q9GZM8 ZNF572 Homo sapiens Q7Z3I7 25416956
种属内
NDEL1 Q9GZM8 ZNF572 Homo sapiens Q7Z3I7 25416956
种属内
NDEL1 Q9GZM8 CCHCR1 Homo sapiens Q8TD31-3 25416956
种属内
NDEL1 Q9GZM8 MBIP Homo sapiens Q9NS73-5 25416956
种属内
NDEL1 Q9GZM8 MBIP Homo sapiens Q9NS73-5 25416956
种属内
NDEL1 Q9GZM8 BORCS6 Homo sapiens Q96GS4 32296183
种属内
NDEL1 Q9GZM8 BORCS6 Homo sapiens Q96GS4 32296183
种属内
NDEL1 Q9GZM8 ZNF844 Homo sapiens Q08AG5 25416956
种属内
NDEL1 Q9GZM8 ZNF844 Homo sapiens Q08AG5 25416956
种属内
NDEL1 Q9GZM8 ZNF260 Homo sapiens Q3ZCT1 25416956
种属内
NDEL1 Q9GZM8 ZNF662 Homo sapiens Q6ZS27-3 32296183
种属内
NDEL1 Q9GZM8 ZNF662 Homo sapiens Q6ZS27-3 32296183
种属内
NDEL1 Q9GZM8 ZNF180 Homo sapiens Q9UJW8 25416956
种属内
NDEL1 Q9GZM8 ZNF180 Homo sapiens Q9UJW8 31413325
种属内
NDEL1 Q9GZM8 ZNF180 Homo sapiens Q9UJW8 25416956
种属内
NDEL1 Q9GZM8 CEP135 Homo sapiens Q66GS9 33961781
种属内
NDEL1 Q9GZM8 CEP135 Homo sapiens Q66GS9 31413325
种属内
NDEL1 Q9GZM8 MIS18A Homo sapiens Q9NYP9 32296183
种属内
NDEL1 Q9GZM8 MIS18A Homo sapiens Q9NYP9 32296183
种属内
NDEL1 Q9GZM8 MIS18A Homo sapiens Q9NYP9 32296183
种属内
NDEL1 Q9GZM8 MIS18A Homo sapiens Q9NYP9 31413325
种属内
NDEL1 Q9GZM8 DIXDC1 Homo sapiens Q155Q3 31413325
种属内
NDEL1 Q9GZM8 DIXDC1 Homo sapiens Q155Q3 33961781
种属内
NDEL1 Q9GZM8 CCSER1 Homo sapiens Q9C0I3 33961781
种属内
NDEL1 Q9GZM8 CCSER1 Homo sapiens Q9C0I3 31413325
种属内
NDEL1 Q9GZM8 ZNF490 Homo sapiens Q9ULM2 25416956
种属内
NDEL1 Q9GZM8 ZNF490 Homo sapiens Q9ULM2 25416956
种属内
NDEL1 Q9GZM8 ZNF490 Homo sapiens Q9ULM2 32296183
种属内
NDEL1 Q9GZM8 IMMT Homo sapiens Q16891-1
Y2H
20880836
种属内
NDEL1 Q9GZM8 IMMT Homo sapiens Q16891-1 20880836
种属内
NDEL1 Q9GZM8 PXN Homo sapiens P49023-2 19492042
种属内
NDEL1 Q9GZM8 PXN Homo sapiens P49023-2 19492042
种属内
NDEL1 Q9GZM8 DISC1 Homo sapiens Q9NRI5-2 32296183
种属内
NDEL1 Q9GZM8 DISC1 Homo sapiens Q9NRI5-2 32296183
种属内
NDEL1 Q9GZM8 DISC1 Homo sapiens Q9NRI5-2 32296183
种属内
NDEL1 Q9GZM8 SNAPC5 Homo sapiens O75971-2 32296183
种属内
NDEL1 Q9GZM8 SNAPC5 Homo sapiens O75971-2 32296183
种属内
NDEL1 Q9GZM8 CLVS2 Homo sapiens Q5SYC1 32296183
种属内
NDEL1 Q9GZM8 CLVS2 Homo sapiens Q5SYC1 32296183
种属内
NDEL1 Q9GZM8 DISC1 Homo sapiens Q9NRI5-1
Y2H
17043677
种属内
NDEL1 Q9GZM8 DISC1 Homo sapiens Q9NRI5-1 20880836
种属内
NDEL1 Q9GZM8 BMI1 Homo sapiens P35226 25416956
种属内
NDEL1 Q9GZM8 BLZF1 Homo sapiens Q9H2G9 32296183
种属内
NDEL1 Q9GZM8 BLZF1 Homo sapiens Q9H2G9 32296183
种属内
NDEL1 Q9GZM8 BLZF1 Homo sapiens Q9H2G9 32296183
种属内
NDEL1 Q9GZM8 TACC3 Homo sapiens Q9Y6A5 32296183
种属内
NDEL1 Q9GZM8 TACC3 Homo sapiens Q9Y6A5 32296183
种属内
NDEL1 Q9GZM8 TACC3 Homo sapiens Q9Y6A5 32296183
种属内
NDEL1 Q9GZM8 CHAT Homo sapiens P28329-3 32814053
种属内
NDEL1 Q9GZM8 CHAT Homo sapiens P28329-3 32814053
种属内
NDEL1 Q9GZM8 CHAT Homo sapiens P28329-3 32814053
种属内
NDEL1 Q9GZM8 ZNF264 Homo sapiens Q14C61 25416956
种属内
NDEL1 Q9GZM8 ZNF264 Homo sapiens Q14C61 25416956
种属内
NDEL1 Q9GZM8 BRK1 Homo sapiens Q8WUW1 31413325
种属内
NDEL1 Q9GZM8 ZNF544 Homo sapiens Q6NX49 25416956
种属内
NDEL1 Q9GZM8 ZNF544 Homo sapiens Q6NX49 31413325
种属内
NDEL1 Q9GZM8 ZNF544 Homo sapiens Q6NX49 31515488
种属内
NDEL1 Q9GZM8 ZNF445 Homo sapiens P59923 31413325
种属内
NDEL1 Q9GZM8 ZNF445 Homo sapiens P59923 33961781
种属内
NDEL1 Q9GZM8 XPA Homo sapiens P23025 25416956
种属内
NDEL1 Q9GZM8 XPA Homo sapiens P23025 25416956
种属内
NDEL1 Q9GZM8 FGFR3 Homo sapiens P22607 32814053
种属内
NDEL1 Q9GZM8 FGFR3 Homo sapiens P22607 32814053
种属内
NDEL1 Q9GZM8 FGFR3 Homo sapiens P22607 32814053
种属内
NDEL1 Q9GZM8 HRAS Homo sapiens P01112 32814053
种属内
NDEL1 Q9GZM8 HRAS Homo sapiens P01112 32814053
种属内
NDEL1 Q9GZM8 HRAS Homo sapiens P01112 32814053
种属内
NDEL1 Q9GZM8 GSN Homo sapiens P06396 32814053
种属内
NDEL1 Q9GZM8 GSN Homo sapiens P06396 32814053
种属内
NDEL1 Q9GZM8 GSN Homo sapiens P06396 32814053
种属内
NDEL1 Q9GZM8 PARVG Homo sapiens Q9HBI0 32296183
种属内
NDEL1 Q9GZM8 MED11 Homo sapiens Q9P086 32296183
种属内
NDEL1 Q9GZM8 MED11 Homo sapiens Q9P086 32296183
种属内
NDEL1 Q9GZM8 MED11 Homo sapiens Q9P086 32296183
种属内
NDEL1 Q9GZM8 DISC1 Homo sapiens Q9NRI5
Y2H
12812986
种属内
NDEL1 Q9GZM8 DISC1 Homo sapiens Q9NRI5 33961781
种属内
NDEL1 Q9GZM8 CWF19L2 Homo sapiens Q2TBE0 25416956
种属内
NDEL1 Q9GZM8 CWF19L2 Homo sapiens Q2TBE0 25416956
种属内
NDEL1 Q9GZM8 GOLGA2 Homo sapiens Q08379 25416956
种属内
NDEL1 Q9GZM8 GOLGA2 Homo sapiens Q08379 25416956
种属内
NDEL1 Q9GZM8 GOLGA2 Homo sapiens Q08379 25416956
种属内
NDEL1 Q9GZM8 PKP2 Homo sapiens Q99959 25416956
种属内
NDEL1 Q9GZM8 PKP2 Homo sapiens Q99959 25416956
种属内
NDEL1 Q9GZM8 CCSER2 Homo sapiens Q9H7U1 33961781
种属内
NDEL1 Q9GZM8 CCSER2 Homo sapiens Q9H7U1 31413325
种属内
NDEL1 Q9GZM8 NDC80 Homo sapiens O14777 25416956
种属内
NDEL1 Q9GZM8 NDC80 Homo sapiens O14777 29892012
种属内
NDEL1 Q9GZM8 TRIM27 Homo sapiens P14373 32296183
种属内
NDEL1 Q9GZM8 TRIM27 Homo sapiens P14373 33961781
种属内
NDEL1 Q9GZM8 TRIM27 Homo sapiens P14373 32296183
种属内
NDEL1 Q9GZM8 PAFAH1B1 Homo sapiens P43034
Y2H
10931877
种属内
NDEL1 Q9GZM8 PAFAH1B1 Homo sapiens P43034 33961781
种属内
NDEL1 Q9GZM8 DTNB Homo sapiens O60941 25416956
种属内
NDEL1 Q9GZM8 ZNF417 Homo sapiens Q8TAU3 25416956
种属内
NDEL1 Q9GZM8 NUP54 Homo sapiens Q7Z3B4 31413325
种属内
NDEL1 Q9GZM8 NUP54 Homo sapiens Q7Z3B4 33961781
种属内
NDEL1 Q9GZM8 UBQLN1 Homo sapiens Q9UMX0 32814053
种属内
NDEL1 Q9GZM8 UBQLN1 Homo sapiens Q9UMX0 32814053
种属内
NDEL1 Q9GZM8 UBQLN1 Homo sapiens Q9UMX0 32814053
种属内
NDEL1 Q9GZM8 ABI3 Homo sapiens Q9P2A4 32296183
种属内
NDEL1 Q9GZM8 DDIT4L Homo sapiens Q96D03 32296183
种属内
NDEL1 Q9GZM8 DDIT4L Homo sapiens Q96D03 32296183
种属内
NDEL1 Q9GZM8 MTUS2 Homo sapiens Q5JR59 25416956
种属内
NDEL1 Q9GZM8 USP2 Homo sapiens O75604 25416956
种属内
NDEL1 Q9GZM8 AIMP2 Homo sapiens Q13155 25416956
种属内
NDEL1 Q9GZM8 AIMP2 Homo sapiens Q13155 25416956
种属内
NDEL1 Q9GZM8 SNAPC5 Homo sapiens O75971 25416956
种属内
NDEL1 Q9GZM8 TRAF3IP3 Homo sapiens Q9Y228 25416956
种属内
NDEL1 Q9GZM8 TRAF3IP3 Homo sapiens Q9Y228 32296183
种属内
NDEL1 Q9GZM8 TRAF3IP3 Homo sapiens Q9Y228 25416956
种属内
NDEL1 Q9GZM8 PICK1 Homo sapiens Q9NRD5 32296183
种属内
NDEL1 Q9GZM8 PICK1 Homo sapiens Q9NRD5 32296183
种属内
NDEL1 Q9GZM8 PICK1 Homo sapiens Q9NRD5 32296183
种属内
NDEL1 Q9GZM8 ZNF57 Homo sapiens Q68EA5 32296183
种属内
NDEL1 Q9GZM8 ZNF57 Homo sapiens Q68EA5 32296183
种属内
NDEL1 Q9GZM8 ZNF599 Homo sapiens Q96NL3 25416956
种属内
NDEL1 Q9GZM8 ZNF599 Homo sapiens Q96NL3 25416956
种属内
NDEL1 Q9GZM8 NDEL1 Homo sapiens Q9GZM8 22843697
种属内
NDEL1 Q9GZM8 NDEL1 Homo sapiens Q9GZM8 22843697
种属内
NDEL1 Q9GZM8 NDEL1 Homo sapiens Q9GZM8 32296183
种属内
NDEL1 Q9GZM8 NDEL1 Homo sapiens Q9GZM8
GMS
22843697
种属内
NDEL1 Q9GZM8 NDEL1 Homo sapiens Q9GZM8 32296183
种属内
NDEL1 Q9GZM8 NDEL1 Homo sapiens Q9GZM8 25416956
种属内
NDEL1 Q9GZM8 NDEL1 Homo sapiens Q9GZM8
Y2H
10931877
种属内
NDEL1 Q9GZM8 NDEL1 Homo sapiens Q9GZM8 32296183
种属内
NDEL1 Q9GZM8 NDEL1 Homo sapiens Q9GZM8 22843697
种属内
NDEL1 Q9GZM8 NDEL1 Homo sapiens Q9GZM8 17997972
种属内
NDEL1 Q9GZM8 NDE1 Homo sapiens Q9NXR1 33961781
种属内
NDEL1 Q9GZM8 CENPF Homo sapiens P49454 17600710
种属内
NDEL1 Q9GZM8 CENPF Homo sapiens P49454
Y2H
17600710
种属内
NDEL1 Q9GZM8 CENPF Homo sapiens P49454 31413325
种属间: 跨种属相互作用 种属内: 同种属相互作用

NDEL1 抗体

目录号 产品名 应用 反应物种
HY-P82227 NUDEL Antibody (YA1972) WB, IHC-P Human, Mouse, Rat
HY-P83349 NDEL1 Antibody (YA3094) WB Human, Mouse

关联疾病

疾病名称 别名
Lissencephaly

Pachygyria

Broad Gyri Of Cerebrum

Large Gyri Of Cerebrum

Macrogyria

Miller-Dieker Lissencephaly Syndrome

Miller-Dieker Syndrome

Mds

MDLS

Miller Dieker Syndrome

Classical Lissencephaly Syndrome

Lissencephaly Due To 17p13.3 Deletion

Monosomy 17p13.3

Telomeric Deletion 17p

Classical Lissencephaly

Lissencephaly 4

LIS4

Lissencephaly 4 With Microcephaly

Microlissencephaly

Lissencephaly, Type 4

Lissencephaly 1

LIS1

Classic Lissencephaly

Ils

Subcortical Laminar Heterotopia

Lissencephaly Due To Lis1 Mutation

Lissencephaly Sequence, Isolated

Lissencephaly, Classic

Pafah1b1-Related Lissencephaly

Classical Lissencephaly

Lissencephaly Type 1

Lissencephaly-1

Subcortical Band Heterotopia

Double Cortex

Lissencephaly Classic

Lissencephaly Sequence Isolated

Isolated Lissencephaly Sequence

Type 1 Lissencephaly

Lissencephaly Syndrome Type 1

SBH

Sclh

Lissencephaly, Type 1

Type I Lissencephaly

Microlissencephaly
Chromosome 17p13.3, Centromeric, Duplication Syndrome

Chromosome 17p13.3 Duplication Syndrome

17p13.3 Duplication Syndrome

17p13.3 Microduplication Syndrome

Trisomy 17p13.3

Chromosome 17p13.3 Centromeric Duplication Syndrome

Dup(17)(P13.3)

Neuronopathy, Distal Hereditary Motor, Type Viib

HMN7B

Hmn Viib

Dhmn7b

Neuropathy, Distal Hereditary Motor, Type Viib

Distal Hereditary Motor Neuronopathy Type 7b

Distal Hereditary Motor Neuropathy Type Viib

Neuronopathy, Distal Hereditary Motor, Type 7b

Neuropathy, Distal Hereditary Motor, With Vocal Cord Paralysis, Type Viib

Lower Motor Neuron Disease, Dynactin Type

Distal Spinal Muscular Atrophy With Vocal Cord Paralysis Type 7b

Harper-Young Myopathy

Neuronopathy, Distal Hereditary Motor, 7b

Distal Hereditary Motor Neuropathy With Vocal Cord Paralysis Type Viib

Lower Motor Neuron Disease Dynactin Type

Plmnd

Progressive Lower Motor Neuron Disease

Neuropathy, Motor, Distal, Hereditary, Type Viib

Band Heterotopia

Subcortical Band Heterotopia

Double Cortex Syndrome

Subcortical Laminar Heterotopia

Double Cortex

Band Heterotopia Of Brain

BH

Heco

Heterotopic Cortex

Familial Band Heterotopia

Dc

Dc Syndrome

Heterotopia, Subcortical Band

Sbh

Sclh

Bhy

Bipolar Disorder

Bipolar Depression

Manic Disorder

Depression, Bipolar

Bipolar Disorder Manic Phase

Depressive-Manic Psych.

Manic Bipolar Affective Disorder

Manic Bipolar I Disorder

Manic Depression

Manic Depressive Disorder

Mixed Bipolar Disorder

Bipolar Affective Disorder

Bipolar Affective Psychosis

Bipolar Spectrum Disorder

Manic Depressive Illness

Depression Bipolar

Bipolar Disorder, Mixed

Major Affective Disorder

Major Affective Disorder 1

Major Affective Disorder 2

Schizophrenia

SCZD

Schizophrenia With Or Without An Affective Disorder

Schizophrenia 12

Schizophrenia, Susceptibility To

Schizophrenia-1

Dementia Praecox

Schizophrenia 1

Autism

Autistic Disorder

Autism Susceptibility 1

Childhood Autism

Autistic Disorder Of Childhood Onset

Infantile Autism

Kanner'S Syndrome

Autistic

Congenital Nervous System Abnormality

Congenital Neurologic Anomaly

Congenital Nervous System Disorder

Psychotic Disorder

Psychotic Disorders

Mental Or Behavioural Disorder

Psychotic

Mental Disorders

Periventricular Nodular Heterotopia

Periventricular Heterotopia

Pvnh

Familial Nodular Heterotopia

Heterotopia, Periventricular

Periventricular Heterotopia, X-Linked

Primary Autosomal Recessive Microcephaly

Autosomal Recessive Primary Microcephaly

Mcph

True Microcephaly

Microcephalia Vera

Microcephaly Vera

Microcephaly Primary Hereditary

Microcephaly, Primary, Autosomal Recessive

Primary Microcephaly

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Bos taurus NDEL1 VGNC VGNC:31933
Rattus norvegicus NDEL1 RGD RGD:621235
Canis familiaris NDEL1 VGNC VGNC:43672
Mus musculus NDEL1 MGD MGI:1932915
Macaca mulatta NDEL1 VGNC VGNC:74982
Felis catus NDEL1 VGNC VGNC:63749