CENPF - centromere protein F Gene

中文名称：着丝粒蛋白 F

种属: Homo sapiens

同用名: CENF; hcp-1; CILD31; STROMS; PRO1779

基因 ID: 1063 | 基因类型: protein coding

关于 CENPF

Cytogenetic location: 1q41 Genomic coordinates (GRCh38): 1:214,603,195-214,664,571 (from NCBI)

This gene has 5 transcripts (splice variants), 189 orthologues and is associated with 4 phenotypes. Broad expression in bone marrow (RPKM 9.7), testis (RPKM 6.0) and 15 other tissues.

功能概要

该基因编码一种与着丝粒-着丝粒复合体相关的蛋白质。该蛋白质是间期 G2 期核基质的组成部分。在 G2 后期，该蛋白质与着丝粒结合，并在早期后期维持这种结合。它分别定位于晚期后期和末期的纺锤体中区和细胞内桥，并且被认为随后被降解。这种蛋白质的定位表明它可能在有丝分裂期间的染色体分离中发挥作用。它被认为形成同二聚体或异二聚体。在患有癌症或移植物抗宿主病的患者中发现了针对这种蛋白质的自身抗体。[RefSeq 提供，2008 年 7 月]

This gene encodes a protein that associates with the centromere-kinetochore complex. The protein is a component of the nuclear matrix during the G2 phase of interphase. In late G2 the protein associates with the kinetochore and maintains this association through early anaphase. It localizes to the spindle midzone and the intracellular bridge in late anaphase and telophase, respectively, and is thought to be subsequently degraded. The localization of this protein suggests that it may play a role in chromosome segregation during mitotis. It is thought to form either a homodimer or heterodimer. Autoantibodies against this protein have been found in patients with Cancer or graft versus host disease. [provided by RefSeq, Jul 2008]

CENPF 基因产物(1)

mRNA	Protein	Name
NM_016343.4	NP_057427.3	centromere protein F

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables DNA-binding transcription factor binding	IPI IPI: 通过物理相互作用推断	15677469	GOA
enables dynein complex binding	IDA IDA: 通过直接分析推断	12974617	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	7642639	GOA
enables protein homodimerization activity	IPI IPI: 通过物理相互作用推断	7642639	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in chromosome segregation	IMP IMP: 通过突变表型推断	16252009	GOA
involved in kidney development	IMP IMP: 通过突变表型推断	25564561	GOA
involved in metaphase chromosome alignment	IDA IDA: 通过直接分析推断	15870278	GOA
involved in mitotic cell cycle	IMP IMP: 通过突变表型推断	7542657	GOA
involved in negative regulation of DNA-templated transcription	IDA IDA: 通过直接分析推断	15677469	GOA
involved in protein transport	IDA IDA: 通过直接分析推断	12974617	GOA
involved in protein transport	IMP IMP: 通过突变表型推断	17600710	GOA
involved in regulation of G2/M transition of mitotic cell cycle	IMP IMP: 通过突变表型推断	7651420	GOA
involved in ventricular system development	IMP IMP: 通过突变表型推断	25564561	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in chromosome, centromeric region	IDA IDA: 通过直接分析推断	7542657	GOA
part of ciliary transition fiber	IMP IMP: 通过突变表型推断	25564561	GOA
located in cytoplasm	IDA IDA: 通过直接分析推断	12974617	GOA
located in kinetochore	IDA IDA: 通过直接分析推断	7542657	GOA
located in midbody	IDA IDA: 通过直接分析推断	7651420	GOA
located in nuclear envelope	IDA IDA: 通过直接分析推断	12154071	GOA
located in nuclear matrix	IDA IDA: 通过直接分析推断	7542657	GOA
located in nucleus	IDA IDA: 通过直接分析推断	7542657	GOA
part of outer kinetochore	IDA IDA: 通过直接分析推断	7542657	GOA
located in spindle	IDA IDA: 通过直接分析推断	7651420	GOA
located in spindle pole	IDA IDA: 通过直接分析推断	7542657	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CENPF 蛋白结构

CENP-F_N

CENP-F_leu_zip

CENP-F_C_Rb_bdg

0
500
1000
1500
2000
2500
3114 a.a.

蛋白主名

其他名称

centromere protein F

AH antigen

CENPF 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	CENPF	P49454	NUP133	Homo sapiens	Q8WUM0	Anti Bait CoIP	17363900
种属内	CENPF	P49454	NDEL1	Homo sapiens	Q9GZM8	Y2H	17600710
种属内	CENPF	P49454	NDEL1	Homo sapiens	Q9GZM8	Y2H	17043677
种属内	CENPF	P49454	NDEL1	Homo sapiens	Q9GZM8	Pull Down	17600710

种属间: 跨种属相互作用 种属内: 同种属相互作用

CENPF 抗体

目录号	产品名	应用	反应物种
HY-P81416	CENPF Antibody (YA1161)	IHC-P	Human

关联疾病

疾病名称

别名

Stromme Syndrome

Jejunal Atresia With Microcephaly And Ocular Anomalies	Apple Peel Syndrome With Microcephaly And Ocular Anomalies
STROMS	Cild31
Lethal Fetal Brain Malformation-Duodenal Atresia-Bilateral Renal Hypoplasia Syndrome	Ciliary Dyskinesia, Primary, 31, Formerly
Cild31, Formerly	Primary Ciliary Dyskinesia 31
Apple-Peel Intestinal Atresia-Ocular Anomalies-Microcephaly Syndrome	Jejunal Atresia-Microcephaly-Ocular Anomalies Syndrome
Ciliary Dyskinesia, Primary, 31	Dyskinesia, Ciliary, Primary, Type 31

Graft-Versus-Host Disease

Graft-Versus-Host Disease, Susceptibility To	Graft Versus Host Disease
GVHDS	Graft-Versus-Host Disease, Protection Against
Gvh	Graft-Vs-Host Disease
Gvhd - [Graft-Versus-Host Disease]	Graft-Versus-Host Reaction Or Disease
Gvh - [Graft-Versus-Host] Disease	Gvh - [Graft-Versus-Host] Reaction

Intestinal Atresia

Cystinuria

CSNU	Cystinuria Type B
Cystinuria Type A	Cystinuria, Type I, Formerly
Csnu1, Formerly	Cystinuria, Type Ii, Formerly
Cystinuria, Type Iii, Formerly	Csnu3, Formerly
Cystinuria, Type Non-I, Formerly	Cystinuria-Lysinuria
Cystinuria-Lysinuria Syndrome	Csnu1
Csnu3	Cystinuria 1
Cystinuria Type A/B	Cystinuria Type I
Cystinuria Type Ii	Cystinuria Type Iii
Cystinuria Type Non-I	Cystinuria, Type A/B
Cystinuria Type 1	Cystinuria - Lysinuria
Csnu - [Cystinuria]	Cystine Disease

Microcephaly

Microencephaly	Microcephalus
Microcephalic	Nanocephaly
Congenital Microcephaly	Brain Hypoplasia
Brain Nondevelopment	Cephalic Hypoplasia
Undeveloped Cerebrum	Undeveloped Brain
Micrencephalon	Micrencephaly

Mosaic Variegated Aneuploidy Syndrome 1

Mva Syndrome	MVA1
Mosaic Variegated Aneuploidy Syndrome, Type 1	Mosaic Variegated Aneuploidy Syndrome
Congenital Chromosomal Disease

Gastric Cancer

Stomach Cancer	Gastric Carcinoma
Stomach Carcinoma	Gastric Cancer, Somatic
Gastric Neoplasm	Carcinoma Of Stomach
Stomach Neoplasms	Malignant Neoplasm Of Stomach
Gastric Cancer Risk After H. Pylori Infection	Cancer Of The Stomach
Adult Stomach Cancer	Adult Stomach Carcinoma
GASC	Gastric Cancer Intestinal
Gastric Cancers	Gastric Carcinomas
Cancer, Gastric	Stomach Neoplasm
Malignant Neoplasm Of Body Of Stomach	Malignant Tumor Of Lesser Curve Of Stomach
Gastrocarcinoma Of Unspecified Site	Leather Bottle Stomach
Carcinoma Of Fundus Of Stomach	Cancer Of Fundus Of Stomach
Primary Malignant Neoplasm Of Body Of Stomach	Cancer Of Body Of Stomach
Primary Malignant Neoplasm Of Pyloric Antrum	Pyloric Antrum Cancer
Malignant Tumour Of Stomach

Familial Apolipoprotein C-Ii Deficiency

Familial Apoc-Ii Deficiency	Familial Apoc2 Deficiency
C-Ii Anapolipoproteinemia	Hyperlipoproteinemia, Type 1b
Hyperlipoproteinemia, Type Ib	Hyperlipoproteinemia Type I

Primary Autosomal Recessive Microcephaly

Autosomal Recessive Primary Microcephaly	Mcph
True Microcephaly	Microcephalia Vera
Microcephaly Vera	Microcephaly Primary Hereditary
Microcephaly, Primary, Autosomal Recessive	Primary Microcephaly

Congenital Nervous System Abnormality

Congenital Neurologic Anomaly

Congenital Nervous System Disorder

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS02479	CENPF Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	CENPF	VGNC	VGNC:27176
Mus musculus	CENPF	MGD	MGI:1313302
Felis catus	CENPF	VGNC	VGNC:107851
Rattus norvegicus	CENPF	RGD	RGD:628667
Macaca mulatta	CENPF	VGNC	VGNC:71009

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