NUP133 - nucleoporin 133 Gene

中文名称：核孔蛋白 133

种属: Homo sapiens

同用名: GAMOS8; NPHS18; hNUP133

基因 ID: 55746 | 基因类型: protein coding

关于 NUP133

Cytogenetic location: 1q42.13 Genomic coordinates (GRCh38): 1:229,440,259-229,508,341 (from NCBI)

This gene has 4 transcripts (splice variants), 207 orthologues and is associated with 5 phenotypes. Ubiquitous expression in testis (RPKM 11.8), brain (RPKM 11.8) and 25 other tissues.

功能概要

核膜在真核细胞中产生不同的核和细胞质区室。它由两个由核孔穿孔的同心膜组成，大型蛋白质复合物形成水通道以调节细胞核和细胞质之间大分子的流动。这些复合物由至少 100 个不同的多肽亚基组成，其中许多属于核孔蛋白家族。由该基因编码的核孔蛋白显示出与其他核孔蛋白在进化上保守的相互作用。这种蛋白质在间期定位于核孔复合体的两侧，在有丝分裂期间仍与复合体相关，并在早期阶段靶向重整核膜。这种蛋白质也定位于有丝分裂细胞的着丝粒。[RefSeq 提供，2008 年 7 月]

The nuclear envelope creates distinct nuclear and cytoplasmic compartments in eukaryotic cells. It consists of two concentric membranes perforated by nuclear pores, large protein complexes that form aqueous channels to regulate the flow of macromolecules between the nucleus and the cytoplasm. These complexes are composed of at least 100 different polypeptide subunits, many of which belong to the nucleoporin family. The nucleoporin protein encoded by this gene displays evolutionarily conserved interactions with Other nucleoporins. This protein, which localizes to both sides of the nuclear pore complex at interphase, remains associated with the complex during mitosis and is targeted at early stages to the reforming nuclear envelope. This protein also localizes to kinetochores of mitotic cells. [provided by RefSeq, Jul 2008]

NUP133 基因产物(1)

mRNA	Protein	Name
NM_018230.3	NP_060700.2	nuclear pore complex protein Nup133

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	11564755	GOA
enables structural constituent of nuclear pore	IDA IDA: 通过直接分析推断	11684705	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in mRNA export from nucleus	IDA IDA: 通过直接分析推断	11684705	GOA
involved in nephron development	IMP IMP: 通过突变表型推断	30179222	GOA
involved in nuclear pore organization	IMP IMP: 通过突变表型推断	15146057	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
colocalizes with kinetochore	IDA IDA: 通过直接分析推断	17098863	GOA
located in nuclear envelope	IDA IDA: 通过直接分析推断	24315095	GOA
part of nuclear pore	IDA IDA: 通过直接分析推断	11564755	GOA
part of nuclear pore outer ring	IDA IDA: 通过直接分析推断	15146057	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

NUP133 蛋白结构

Nucleoporin_N

Nucleoporin_C

0
200
400
600
800
1000
1156 a.a.

蛋白主名

其他名称

nuclear pore complex protein Nup133

133 kDa nucleoporin

NUP133 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属间	NUP133	Q8WUM0	NUP85	Saccharomyces cerevisiae	P46673	Y2H Array	27194810
种属间	NUP133	Q8WUM0	NUP85	Saccharomyces cerevisiae	P46673	MST	27194810
种属内	NUP133	Q8WUM0	NUP107	Homo sapiens	P57740	Anti Bait CoIP	17363900
种属内	NUP133	Q8WUM0	NUP107	Homo sapiens	P57740	Anti Tag CoIP	30179222
种属内	NUP133	Q8WUM0	NUP107	Homo sapiens	P57740	Y2H	11564755
种属内	NUP133	Q8WUM0	NUP107	Homo sapiens	P57740	Anti Tag CoIP	33961781
种属内	NUP133	Q8WUM0	NUP107	Homo sapiens	P57740	Y2H Array	27194810
种属内	NUP133	Q8WUM0	NUP107	Homo sapiens	P57740	CoIP	11564755
种属内	NUP133	Q8WUM0	NUP107	Homo sapiens	P57740	BiFC	27194810
种属内	NUP133	Q8WUM0	LRRK2	Homo sapiens	Q5S007	Protein Array	24947832
种属内	NUP133	Q8WUM0	NUP85	Homo sapiens	Q9BW27	Anti Tag CoIP	33961781
种属内	NUP133	Q8WUM0	NUP85	Homo sapiens	Q9BW27	BiFC	27194810
种属内	NUP133	Q8WUM0	CENPF	Homo sapiens	P49454	Y2H	17363900

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Galloway-Mowat Syndrome 8

GAMOS8

Nephrotic Syndrome, Type 18

NPHS18	Nephrotic Syndrome Type 18
Nephrotic Syndrome 18

Galloway-Mowat Syndrome

Galloway Mowat Syndrome	Galloway Syndrome
Hiatal Hernia-Microcephaly-Nephrosis, Galloway Type	Microcephaly Nephrosis Syndrome
Microcephaly, Hiatal Hernia, And Nephrotic Syndrome	Nephrosis Neuronal Dysmigration Syndrome
Microcephaly-Hiatus Hernia-Nephrotic Syndrome	Nephrosis-Neuronal Dysmigration Syndrome

Genetic Steroid-Resistant Nephrotic Syndrome

Familial Idiopathic Steroid-Resistant Nephrotic Syndrome	Genetic Srns
Hereditary Steroid-Resistant Nephrotic Syndrome	Familial Idiopathic Nephrotic Syndrome
Nephrotic Syndrome, Steroid-Resistant, Autosomal Recessive	Srn1

Nephrotic Syndrome

Finnish Congenital Nephrotic Syndrome	Ns - [Nephrotic Syndrome]
Nephrosis Syndrome	Nephrosis Nos
Glomerular Lesion Nephrosis

Achalasia-Addisonianism-Alacrima Syndrome

Allgrove Syndrome	Triple-A Syndrome
Achalasia-Addisonianism-Alacrimia Syndrome	Alacrima-Achalasia-Adrenal Insufficiency Neurologic Disorder
Triple A Syndrome	Aaa Syndrome
AAAS	Glucocorticoid Deficiency With Achalasia
Glucocorticoid Deficiency And Achalasia	Addisonian-Achalasia Syndrome
Hypoadrenalism With Achalasia	Alacrima-Achalasia-Addisonianism
Aaa	Acth-Resistant Adrenal Insufficiency, Achalasia And Alacrima
Achalasia Addisonianism Alacrimia Syndrome	Achalasia Alacrima Syndrome
Addisonian Achalasia Syndrome	Achalasia-Addisonian Syndrome
Achalasia-Alacrima Syndrome	2a Syndrome
3a Syndrome	4a Syndrome
Adrenal Insufficiency-Achalasia-Alacrima Syndrome	Double A Syndrome
Quaternary A Syndrome	Acth-Resistant Adrenal Insufficiency With Achalasia And Alacrima
Allgrove'S Syndrome	Adrenal Gland Hypofunction
Adrenal Cortical Hypofunction

Focal Segmental Glomerulosclerosis

Familial Idiopathic Steroid-Resistant Nephrotic Syndrome	Focal Glomerulosclerosis
Fsgs	Segmental Glomerulosclerosis
Glomerulosclerosis, Focal Segmental	Fgs
Focal Glomerular Sclerosis	Familial Idiopathic Nephrotic Syndrome
Focal Sclerosis With Hyalinosis	Glomerulosclerosis, Focal
Glomerulosclerosis Focal	Glomerulosclerosis, Segmental, Focal
Focal Segmental Glomerulosclerosis, Not Otherwise Specified

Lissencephaly

Pachygyria	Broad Gyri Of Cerebrum
Large Gyri Of Cerebrum	Macrogyria

Autoimmune Lymphoproliferative Syndrome

ALPS	Canale-Smith Syndrome
Autoimmune Lymphoproliferative Syndrome, Type Ia	Autoimmune Lymphoproliferative Syndrome, Type Ib
Autoimmune Lymphoproliferative Syndrome Type 1, Autosomal Dominant	Css
Autoimmune Lymphoproliferative Syndrome, Type 1b	Autoimmune Lymphoproliferative Syndrome, Type 1a
Autoimmune Lymphoproliferative Syndrome, Type I, Autosomal Dominant	Fas Deficiency
Autoimmune Lymphoproliferative Syndrome 1a	ALPS1A
Autoimmune Lymphoproliferative Syndrome Type Ia	Autoimmune Lymphoproliferative Syndrome 1b
ALPS1B	Autoimmune Lymphoproliferative Syndrome Type Ib

Polymicrogyria

Pmg

Microcephaly

Microencephaly	Microcephalus
Microcephalic	Nanocephaly
Congenital Microcephaly	Brain Hypoplasia
Brain Nondevelopment	Cephalic Hypoplasia
Undeveloped Cerebrum	Undeveloped Brain
Micrencephalon	Micrencephaly

Congenital Nervous System Abnormality

Congenital Neurologic Anomaly

Congenital Nervous System Disorder

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS09684	NUP133 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	NUP133	VGNC	VGNC:75428
Mus musculus	NUP133	MGD	MGI:2442620
Felis catus	NUP133	VGNC	VGNC:63919
Bos taurus	NUP133	VGNC	VGNC:32351
Canis familiaris	NUP133	VGNC	VGNC:44045
Rattus norvegicus	NUP133	RGD	RGD:1307827

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站点地图隐私声明

沪ICP备15051369号-4

上海工商

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沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

NUP133 - nucleoporin 133 Gene

关于 NUP133

功能概要

NUP133 基因产物(1)

NUP133 蛋白结构

NUP133 蛋白互作信息

关联疾病

直系同源

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NUP133 - nucleoporin 133 Gene

关于 NUP133

功能概要

NUP133 基因产物(1)

NUP133 蛋白结构

NUP133 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z