2. Gene
  3. NUP85 - nucleoporin 85 Gene

NUP85 - nucleoporin 85 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：核孔蛋白 85

种属: Homo sapiens

同用名: Nup75; FROUNT; NPHS17

基因 ID: 79902 | 基因类型: protein coding

关于 NUP85

Cytogenetic location: 17q25.1 Genomic coordinates (GRCh38): 17:75,205,679-75,235,758 (from NCBI)

This gene has 25 transcripts (splice variants), 214 orthologues and is associated with 3 phenotypes. Ubiquitous expression in lymph node (RPKM 9.1), testis (RPKM 9.0) and 25 other tissues.

功能概要

该基因编码核孔复合体 Nup107-160 亚基的蛋白质成分。核孔复合物嵌入核膜中，促进大分子在细胞质和细胞核之间的双向运输。编码的蛋白还可以结合趋化因子 (CC 基序) 受体 2 (CCR2) 的 C 端，促进单核细胞的趋化性，从而参与炎症反应。可变剪接导致多个转录本变体。[RefSeq 提供，2014 年 12 月]

This gene encodes a protein component of the Nup107-160 subunit of the nuclear pore complex. Nuclear pore complexes are embedded in the nuclear envelope and promote bidirectional transport of macromolecules between the cytoplasm and nucleus. The encoded protein can also bind to the C-terminus of chemokine (C-C motif) receptor 2 (CCR2) and promote chemotaxis of monocytes, thereby participating in the inflammatory response. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]

NUP85 基因产物(3)

mRNA Protein Name
NM_001303276.2 NP_001290205.1 nuclear pore complex protein Nup85 isoform 2
NM_001330472.2 NP_001317401.1 nuclear pore complex protein Nup85 isoform 3
NM_024844.5 NP_079120.1 nuclear pore complex protein Nup85 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
15146057 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in nephron development IMP
IMP: 通过突变表型推断
30179222 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
colocalizes with kinetochore IDA
IDA: 通过直接分析推断
15146057 GOA
located in nuclear envelope IDA
IDA: 通过直接分析推断
24315095 GOA
part of nuclear pore outer ring IDA
IDA: 通过直接分析推断
15146057 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

NUP85 蛋白结构

Nucleopor_Nup85

Nucleopor_Nup85: Nup85 Nucleoporin (53 - 607)

  • 0
  • 200
  • 400
  • 600
  • 656 a.a.
蛋白主名 其他名称

nuclear pore complex protein Nup85

nucleoporin 85kDa

NUP85 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra NUP85 Q9BW27 CCR2 Homo sapiens P41597-2
SPR
25283965
Intra NUP85 Q9BW27 CCR2 Homo sapiens P41597-2
NMR
25283965
Intra NUP85 Q9BW27 NUP133 Homo sapiens Q8WUM0
Affinity Chrom
24315095
Intra NUP85 Q9BW27 NUP160 Homo sapiens Q12769
Anti Tag CoIP
30179222
Intra NUP85 Q9BW27 NUP160 Homo sapiens Q12769
Affinity Chrom
24315095
Intra NUP85 Q9BW27 GET4 Homo sapiens Q7L5D6
Y2H Prey Pooling
32296183
Intra NUP85 Q9BW27 GET4 Homo sapiens Q7L5D6
Y2H Array
32296183
Intra NUP85 Q9BW27 SEH1L Homo sapiens Q96EE3
GMS
26391640
Intra NUP85 Q9BW27 SEH1L Homo sapiens Q96EE3
Affinity Chrom
24315095
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Nephrotic Syndrome, Type 17

NPHS17

Nephrotic Syndrome Type 17

Nephrotic Syndrome 17
Seckel Syndrome

Microcephalic Primordial Dwarfism

Bird-Headed Dwarfism

Harper'S Syndrome

Virchow-Seckel Dwarfism

Nanocephalic Dwarfism

Sckl

Seckel-Type Dwarfism
Genetic Steroid-Resistant Nephrotic Syndrome

Familial Idiopathic Steroid-Resistant Nephrotic Syndrome

Genetic Srns

Hereditary Steroid-Resistant Nephrotic Syndrome

Familial Idiopathic Nephrotic Syndrome

Nephrotic Syndrome, Steroid-Resistant, Autosomal Recessive

Srn1
Nephrotic Syndrome

Finnish Congenital Nephrotic Syndrome

Ns - [Nephrotic Syndrome]

Nephrosis Syndrome

Nephrosis Nos

Glomerular Lesion Nephrosis
Seckel Syndrome 8

SCKL8

Seckel Syndrome, Type 8
Focal Segmental Glomerulosclerosis

Familial Idiopathic Steroid-Resistant Nephrotic Syndrome

Focal Glomerulosclerosis

Fsgs

Segmental Glomerulosclerosis

Glomerulosclerosis, Focal Segmental

Fgs

Focal Glomerular Sclerosis

Familial Idiopathic Nephrotic Syndrome

Focal Sclerosis With Hyalinosis

Glomerulosclerosis, Focal

Glomerulosclerosis Focal

Glomerulosclerosis, Segmental, Focal

Focal Segmental Glomerulosclerosis, Not Otherwise Specified
Autoimmune Lymphoproliferative Syndrome

ALPS

Canale-Smith Syndrome

Autoimmune Lymphoproliferative Syndrome, Type Ia

Autoimmune Lymphoproliferative Syndrome, Type Ib

Autoimmune Lymphoproliferative Syndrome Type 1, Autosomal Dominant

Css

Autoimmune Lymphoproliferative Syndrome, Type 1b

Autoimmune Lymphoproliferative Syndrome, Type 1a

Autoimmune Lymphoproliferative Syndrome, Type I, Autosomal Dominant

Fas Deficiency

Autoimmune Lymphoproliferative Syndrome 1a

ALPS1A

Autoimmune Lymphoproliferative Syndrome Type Ia

Autoimmune Lymphoproliferative Syndrome 1b

ALPS1B

Autoimmune Lymphoproliferative Syndrome Type Ib
Microcephaly

Microencephaly

Microcephalus

Microcephalic

Nanocephaly

Congenital Microcephaly

Brain Hypoplasia

Brain Nondevelopment

Cephalic Hypoplasia

Undeveloped Cerebrum

Undeveloped Brain

Micrencephalon

Micrencephaly
Primary Autosomal Recessive Microcephaly

Autosomal Recessive Primary Microcephaly

Mcph

True Microcephaly

Microcephalia Vera

Microcephaly Vera

Microcephaly Primary Hereditary

Microcephaly, Primary, Autosomal Recessive

Primary Microcephaly
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS09698 NUP85 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus NUP85 RGD RGD:1311942
Macaca mulatta NUP85 VGNC VGNC:75591
Bos taurus NUP85 VGNC VGNC:32364
Canis familiaris NUP85 VGNC VGNC:44060
Felis catus NUP85 VGNC VGNC:68728
Mus musculus NUP85 MGD MGI:3046173
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