2. Gene
  3. GET4 - guided entry of tail-anchored proteins factor 4 Gene

GET4 - guided entry of tail-anchored proteins factor 4 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品

中文名称：尾锚定蛋白因子 4 的引导进入

种属: Homo sapiens

同用名: CEE; TRC35; CGI-20; C7orf20

基因 ID: 51608 | 基因类型: protein coding

关于 GET4

Cytogenetic location: 7p22.3 Genomic coordinates (GRCh38): 7:876,554-896,436 (from NCBI)

This gene has 7 transcripts (splice variants) and 205 orthologues. Ubiquitous expression in testis (RPKM 20.0), adrenal (RPKM 15.8) and 25 other tissues.

功能概要

启用伴侣结合活动。参与蛋白质的细胞质螯合；维持参与 ERAD 通路的未折叠蛋白；和尾锚定膜蛋白插入 ER 膜。位于染色体；胞质溶胶；和核腔。 BAT3 复合体的一部分。 [由基因组资源联盟提供，2022 年 4 月]

Enables chaperone binding activity. Involved in cytoplasmic sequestering of protein; maintenance of unfolded protein involved in ERAD pathway; and tail-anchored membrane protein insertion into ER membrane. Located in chromosome; cytosol; and nuclear lumen. Part of BAT3 complex. [provided by Alliance of Genome Resources, Apr 2022]

GET4 基因产物(1)

mRNA Protein Name
NM_015949.3 NP_057033.2 Golgi to ER traffic protein 4 homolog

GET4 蛋白结构

DUF410

DUF410: Protein of unknown function (DUF410) (54 - 302)

  • 0
  • 100
  • 200
  • 300
  • 327 a.a.
蛋白主名 其他名称

Golgi to ER traffic protein 4 homolog

H_NH1244M04.5

GET4 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
GET4 Q7L5D6 KRTAP9-3 Homo sapiens Q9BYQ3
Validated Y2H
32296183
种属内
GET4 Q7L5D6 PRKAB2 Homo sapiens O43741
Y2H Prey Pooling
25416956
种属内
GET4 Q7L5D6 PRKAB2 Homo sapiens O43741
Y2H Array
25416956
种属内
GET4 Q7L5D6 PRKAB2 Homo sapiens O43741
Y2H
21516116
种属内
GET4 Q7L5D6 BAG6 Homo sapiens P46379-2
Anti Tag CoIP
28514442
种属内
GET4 Q7L5D6 FBN1 Homo sapiens P35555
Y2H Prey Pooling
32296183
种属内
GET4 Q7L5D6 GET3 Homo sapiens O43681
Anti Tag CoIP
33961781
种属内
GET4 Q7L5D6 NUP85 Homo sapiens Q9BW27
Validated Y2H
32296183
种属内
GET4 Q7L5D6 DUSP21 Homo sapiens Q9H596
Validated Y2H
32296183
种属内
GET4 Q7L5D6 ENKD1 Homo sapiens Q9H0I2
Validated Y2H
32296183
种属内
GET4 Q7L5D6 AIRIM Homo sapiens Q9NX04
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Louping Ill
Hypotrichosis 2

HYPT2

Hypotrichosis Simplex Of The Scalp 1

Htss1

Htss

Hypotrichosis, Spanish Type

Spanish Type Hypotrichosis

Hypotrichosis Spanish Type

Hypotrichosis, Type 2

Hypotrichosis Simplex Of Scalp
Eastern Equine Encephalitis

Eee

Neuroinvasive Eastern Equine Encephalitis Virus Infection

Eastern Equine Encephalomyelitis

Encephalomyelitis, Eastern Equine

Triple E

Eastern Equine Encephalitis Virus Infection

Neuroinvasive Eastern Equine Encephalitis Virus Disease

Eee - [Eastern Equine Encephalitis]
Saethre-Chotzen Syndrome

SCS

Acs3

Acs Iii

Chotzen Syndrome

Acrocephaly, Skull Asymmetry, And Mild Syndactyly

Acrocephalosyndactyly Type 3

Acrocephalosyndactyly, Type Iii

Acrocephalosyndactyly Type Iii

Saethre-Chotzen Syndrome With Or Without Eyelid Anomalies

Auralcephalosyndactyly

Acs 3

Acrocephalo-Syndactyly, Type 3

Blepharophimosis,Epicanthus Inversus, And Ptosis 3

Aural Cephalosyndactyly

Kurczynski-Casperson Syndrome

Acrocephalosyndactyly Iii

Dysostosis Craniofacialis With Hypertelorism

Saethre-Chotzen Syndrome, With/Without Eyelid Anomalies

Sakati Syndrome
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS05375 GET4 Human Pre-designed siRNA Set A Pre-designed Sets / 否
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