2. Gene
  3. GET3 - guided entry of tail-anchored proteins factor 3, ATPase Gene

GET3 - guided entry of tail-anchored proteins factor 3, ATPase Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：引导进入尾锚定蛋白因子 3，ATPase

种属: Homo sapiens

同用名: ARSA1; ASNA1; TRC40; ARSA-I; ASNA-I

基因 ID: 439 | 基因类型: protein coding

关于 GET3

Cytogenetic location: 19p13.13 Genomic coordinates (GRCh38): 19:12,737,106-12,748,323 (from NCBI)

This gene has 3 transcripts (splice variants) and 204 orthologues. Ubiquitous expression in kidney (RPKM 39.3), thyroid (RPKM 34.9) and 25 other tissues.

功能概要

该基因代表细菌 arsA 基因的人类同系物，编码亚砷酸盐转运蛋白中亚砷酸盐刺激的 ATP 酶成分，负责抗砷。该蛋白也是跨膜结构域 (TMD) 识别复合物 (TRC) 的核心成分，该复合物参与尾部锚定 (TA) 蛋白从胞质溶胶到内质网 (ER) 的翻译后递送。它识别并选择性结合胞质溶胶中 TA 蛋白的 TMD，并将其递送至 ER 进行插入。[RefSeq 提供，2011 年 10 月]

This gene represents the human homolog of the Bacterial arsA gene, encoding the arsenite-stimulated ATPase component of the arsenite transporter responsible for resistance to arsenicals. This protein is also a central component of a transmembrane domain (TMD) recognition complex (TRC) that is involved in the post-translational delivery of tail-anchored (TA) proteins from the cytosol to the endoplasmic reticulum (ER). It recognizes and selectively binds the TMD of TA proteins in the cytosol, and delivers them to the ER for insertion. [provided by RefSeq, Oct 2011]

GET3 基因产物(3)

mRNA Protein Name
NM_001371488.1 NP_001358417.1 ATPase GET3
NM_001371489.1 NP_001358418.1 ATPase GET3
NM_004317.4 NP_004308.2 ATPase GET3
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables membrane insertase activity IDA
IDA: 通过直接分析推断
23610396 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
21516116 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in tail-anchored membrane protein insertion into ER membrane IDA
IDA: 通过直接分析推断
25535373 GOA
involved in tail-anchored membrane protein insertion into ER membrane IMP
IMP: 通过突变表型推断
23041287 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of GET complex IDA
IDA: 通过直接分析推断
32910895 GOA
part of GET complex IPI
IPI: 通过物理相互作用推断
23041287 GOA
is active in endoplasmic reticulum membrane IDA
IDA: 通过直接分析推断
32910895 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

GET3 蛋白结构

ArsA_ATPase

ArsA_ATPase: Anion-transporting ATPase (38 - 339)

  • 0
  • 100
  • 200
  • 300
  • 348 a.a.
蛋白主名 其他名称

ATPase GET3

arsA arsenite transporter, ATP-binding, homolog 1

GET3 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra GET3 O43681 PDIA6 Homo sapiens Q15084
Y2H Prey Pooling
32296183
Intra GET3 O43681 PDIA6 Homo sapiens Q15084
Validated Y2H
32296183
Intra GET3 O43681 PDIA6 Homo sapiens Q15084
Y2H Array
32296183
Intra GET3 O43681 PGRMC2 Homo sapiens O15173
Y2H Prey Pooling
32296183
Intra GET3 O43681 PGRMC2 Homo sapiens O15173
Y2H Array
32296183
Intra GET3 O43681 TMX1 Homo sapiens Q9H3N1
Validated Y2H
32296183
Intra GET3 O43681 TMX1 Homo sapiens Q9H3N1
Y2H Prey Pooling
32296183
Intra GET3 O43681 TMX1 Homo sapiens Q9H3N1
Y2H Array
32296183
Intra GET3 O43681 GPX8 Homo sapiens Q8TED1
Y2H Array
32296183
Intra GET3 O43681 GPX8 Homo sapiens Q8TED1
Y2H Prey Pooling
32296183
Intra GET3 O43681 GPX8 Homo sapiens Q8TED1
Validated Y2H
32296183
Intra GET3 O43681 KCNE4 Homo sapiens Q8WWG9
Validated Y2H
32296183
Intra GET3 O43681 KCNE4 Homo sapiens Q8WWG9
Y2H Prey Pooling
32296183
Intra GET3 O43681 KCNE4 Homo sapiens Q8WWG9
Y2H Array
32296183
Intra GET3 O43681 FAM163A Homo sapiens Q96GL9
Y2H Prey Pooling
32296183
Intra GET3 O43681 FAM163A Homo sapiens Q96GL9
Validated Y2H
32296183
Intra GET3 O43681 FAM163A Homo sapiens Q96GL9
Y2H Array
32296183
Intra GET3 O43681 VWC2 Homo sapiens Q2TAL6
Validated Y2H
32296183
Intra GET3 O43681 VWC2 Homo sapiens Q2TAL6
Y2H Array
32296183
Intra GET3 O43681 VWC2 Homo sapiens Q2TAL6
Y2H Prey Pooling
32296183
Intra GET3 O43681 KCNE5 Homo sapiens Q9UJ90
Y2H Array
32296183
Intra GET3 O43681 KCNE5 Homo sapiens Q9UJ90
Y2H Prey Pooling
32296183
Intra GET3 O43681 KCNE5 Homo sapiens Q9UJ90
Validated Y2H
32296183
Intra GET3 O43681 EMSY Homo sapiens Q7Z589-5
Validated Y2H
32296183
Intra GET3 O43681 EMSY Homo sapiens Q7Z589-5
Y2H Array
32296183
Intra GET3 O43681 EMSY Homo sapiens Q7Z589-5
Y2H Prey Pooling
32296183
Intra GET3 O43681 ASPH Homo sapiens Q12797-6
Validated Y2H
32296183
Intra GET3 O43681 LDLRAD4 Homo sapiens O15165-2
Y2H Array
32296183
Intra GET3 O43681 LDLRAD4 Homo sapiens O15165-2
Y2H Prey Pooling
32296183
Intra GET3 O43681 TMEM154 Homo sapiens Q6P9G4
Y2H Prey Pooling
32296183
Intra GET3 O43681 TMEM154 Homo sapiens Q6P9G4
Validated Y2H
32296183
Intra GET3 O43681 TMEM154 Homo sapiens Q6P9G4
Y2H Array
32296183
Intra GET3 O43681 PRB3 Homo sapiens Q04118
Y2H Prey Pooling
32296183
Intra GET3 O43681 PRB3 Homo sapiens Q04118
Validated Y2H
32296183
Intra GET3 O43681 PRB3 Homo sapiens Q04118
Y2H Array
32296183
Intra GET3 O43681 SSMEM1 Homo sapiens Q8WWF3
Y2H Prey Pooling
32296183
Intra GET3 O43681 SSMEM1 Homo sapiens Q8WWF3
Validated Y2H
32296183
Intra GET3 O43681 SSMEM1 Homo sapiens Q8WWF3
Y2H Array
32296183
Intra GET3 O43681 CAMLG Homo sapiens P49069
Y2H Prey Pooling
32296183
Intra GET3 O43681 CAMLG Homo sapiens P49069
Complementation
32296183
Intra GET3 O43681 CAMLG Homo sapiens P49069
Anti Tag CoIP
33961781
Intra GET3 O43681 CAMLG Homo sapiens P49069
Y2H Array
32296183
Intra GET3 O43681 CAMLG Homo sapiens P49069
Validated Y2H
32296183
Intra GET3 O43681 SMIM19 Homo sapiens Q96E16
Y2H Array
32296183
Intra GET3 O43681 SMIM19 Homo sapiens Q96E16
Validated Y2H
32296183
Intra GET3 O43681 SMIM19 Homo sapiens Q96E16
Y2H Prey Pooling
32296183
Intra GET3 O43681 SYPL2 Homo sapiens Q5VXT5-2
Y2H Prey Pooling
32296183
Intra GET3 O43681 SYPL2 Homo sapiens Q5VXT5-2
Validated Y2H
32296183
Intra GET3 O43681 SYPL2 Homo sapiens Q5VXT5-2
Y2H Array
32296183
Intra GET3 O43681 RHEX Homo sapiens Q6ZWK4
Y2H Prey Pooling
32296183
Intra GET3 O43681 RHEX Homo sapiens Q6ZWK4
Y2H Array
32296183
Intra GET3 O43681 RHEX Homo sapiens Q6ZWK4
Validated Y2H
32296183
Intra GET3 O43681 FAM209A Homo sapiens Q5JX71
Y2H Prey Pooling
32296183
Intra GET3 O43681 FAM209A Homo sapiens Q5JX71
Validated Y2H
32296183
Intra GET3 O43681 FAM209A Homo sapiens Q5JX71
Y2H Array
32296183
Intra GET3 O43681 CSPG5 Homo sapiens O95196-2
Validated Y2H
32296183
Intra GET3 O43681 CSPG5 Homo sapiens O95196-2
Y2H Prey Pooling
32296183
Intra GET3 O43681 CSPG5 Homo sapiens O95196-2
Y2H Array
32296183
Intra GET3 O43681 ASPH Homo sapiens Q12797
Y2H Prey Pooling
25416956
Intra GET3 O43681 FKBP7 Homo sapiens Q9Y680
Y2H Prey Pooling
32296183
Intra GET3 O43681 FKBP7 Homo sapiens Q9Y680
Validated Y2H
32296183
Intra GET3 O43681 FKBP7 Homo sapiens Q9Y680
Y2H Array
32296183
Intra GET3 O43681 CREB3L4 Homo sapiens Q8TEY5
Validated Y2H
32296183
Intra GET3 O43681 CREB3L4 Homo sapiens Q8TEY5
Y2H Array
32296183
Intra GET3 O43681 CREB3L4 Homo sapiens Q8TEY5
Y2H Prey Pooling
32296183
Intra GET3 O43681 PEX14 Homo sapiens O75381
Y2H Prey Pooling
32296183
Intra GET3 O43681 PEX14 Homo sapiens O75381
Validated Y2H
32296183
Intra GET3 O43681 PEX14 Homo sapiens O75381
Y2H Array
32296183
Cross GET3 O43681 yscD Yersinia pestis Q56975
Y2H Array
21911467
Intra GET3 O43681 GET4 Homo sapiens Q7L5D6
Y2H Array
32296183
Intra GET3 O43681 GET4 Homo sapiens Q7L5D6
Validated Y2H
32296183
Intra GET3 O43681 GET4 Homo sapiens Q7L5D6
Y2H Prey Pooling
32296183
Intra GET3 O43681 GET4 Homo sapiens Q7L5D6
Y2H
21516116
Intra GET3 O43681 GOLM1 Homo sapiens Q8NBJ4
Y2H Prey Pooling
32296183
Intra GET3 O43681 GOLM1 Homo sapiens Q8NBJ4
Validated Y2H
32296183
Intra GET3 O43681 GOLM1 Homo sapiens Q8NBJ4
Y2H Array
32296183
Intra GET3 O43681 AGR2 Homo sapiens O95994
Validated Y2H
32296183
Intra GET3 O43681 AGR2 Homo sapiens O95994
Y2H Array
32296183
Intra GET3 O43681 AGR2 Homo sapiens O95994
Y2H Prey Pooling
32296183
Intra GET3 O43681 SPP1 Homo sapiens P10451
Y2H Prey Pooling
32296183
Intra GET3 O43681 SPP1 Homo sapiens P10451
Validated Y2H
32296183
Intra GET3 O43681 SPP1 Homo sapiens P10451
Y2H Array
32296183
Intra GET3 O43681 TMEM51 Homo sapiens Q9NW97
Validated Y2H
32296183
Intra GET3 O43681 TMEM51 Homo sapiens Q9NW97
Y2H Array
32296183
Intra GET3 O43681 PRR4 Homo sapiens Q16378
Y2H Array
32296183
Intra GET3 O43681 PRR4 Homo sapiens Q16378
Y2H Prey Pooling
32296183
Intra GET3 O43681 PRR4 Homo sapiens Q16378
Validated Y2H
32296183
Intra GET3 O43681 DDIT4L Homo sapiens Q96D03
Y2H Array
32296183
Intra GET3 O43681 DDIT4L Homo sapiens Q96D03
Validated Y2H
32296183
Intra GET3 O43681 DDIT4L Homo sapiens Q96D03
Y2H Prey Pooling
32296183
Intra GET3 O43681 GPX7 Homo sapiens Q96SL4
Validated Y2H
32296183
Intra GET3 O43681 GPX7 Homo sapiens Q96SL4
Y2H Array
32296183
Intra GET3 O43681 GPX7 Homo sapiens Q96SL4
Y2H Array
25416956
Intra GET3 O43681 GPX7 Homo sapiens Q96SL4
Y2H Prey Pooling
32296183
Intra GET3 O43681 WFDC3 Homo sapiens Q8IUB2
Validated Y2H
32296183
Intra GET3 O43681 WFDC3 Homo sapiens Q8IUB2
Y2H Prey Pooling
32296183
Intra GET3 O43681 WFDC3 Homo sapiens Q8IUB2
Y2H Array
32296183
Intra GET3 O43681 IGFBP6 Homo sapiens P24592
Y2H Array
32296183
Intra GET3 O43681 IGFBP6 Homo sapiens P24592
Y2H Prey Pooling
32296183
Intra GET3 O43681 IGFBP6 Homo sapiens P24592
Validated Y2H
32296183
Intra GET3 O43681 RCN1 Homo sapiens Q15293
Y2H Array
32296183
Intra GET3 O43681 RCN1 Homo sapiens Q15293
Y2H Prey Pooling
32296183
Intra GET3 O43681 RCN1 Homo sapiens Q15293
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Breast Adenoma

Ademoma - Breast
Nephronophthisis 1

NPHP1

Nephronophthisis, Familial Juvenile

Nph1

Nephronophthisis 1, Juvenile

Juvenile Nephronophthisis 1

Familial Juvenile Nephronophthisis 1

Nephronophthisis, Type 1
Peroxisome Biogenesis Disorder 1b

Peroxisome Biogenesis Disorder

Infantile Refsum Disease

Infantile Phytanic Acid Storage Disease

PBD1B

Refsum Disease, Infantile

Adrenoleukodystrophy, Autosomal Neonatal

Ird

Mild Pbd-Zsd

Mild Peroxisome Biogenesis Disorder-Zellweger Spectrum Disorder

Pbd-Zsd

Peroxisome Biogenesis Disorder Spectrum

Peroxisome Biogenesis Disorder-Zellweger Spectrum Disorder

Autosomal Neonatal Adrenoleukodystrophy

Refsum Disease Infantile

Peroxisome Biogenesis Disorders

Peroxisome Biogenesis Disorder, Type 1b
Peroxisomal Biogenesis Disorder

Zellweger Spectrum Disorders

Peroxisome Biogenesis Disorder-Zellweger Syndrome Spectrum

Disorders Of Peroxisome Biogenesis

Zellweger Spectrum

Zellweger Syndrome Spectrum

Peroxisomal Biogenesis Disorders

Pbd, Zss

Pbd-Zsd

Pbd-Zss

Pbd-Zellweger Spectrum Disorder

Peroxisomal Biogenesis Disorders, Zellweger Syndrome Spectrum

Peroxisome Biogenesis Disorder

Peroxisome Biogenesis Disorder Spectrum

Peroxisome Biogenesis Disorders

Zellweger Spectrum Disorder

Hyperpipecolic Acidaemia
Zellweger Syndrome

Cerebrohepatorenal Syndrome

Zellweger Leukodystrophy

Zs

Congenital Iron Overload

Chr

Zws

Severe Pbd-Zsd

Severe Peroxisome Biogenesis Disorder-Zellweger Spectrum Disorder
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS05374 GET3 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus GET3 MGD MGI:1928379
Rattus norvegicus GET3 RGD RGD:1307906
Felis catus GET3 VGNC VGNC:80262
Macaca mulatta GET3 VGNC VGNC:80258
Bos taurus GET3 VGNC VGNC:96696
Canis familiaris GET3 VGNC VGNC:102781
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