CAMLG - calcium modulating ligand Gene

中文名称：钙调节配体

种属: Homo sapiens

同用名: CAML; GET2

关于 CAMLG

功能概要

免疫抑制剂药物环孢菌素 A 可阻断来自 T 细胞受体 (TCR) 的钙依赖性信号，该信号通常会导致 T 细胞活化。当与亲环蛋白 B 结合时，环孢菌素 A 结合并灭活关键的信号传导中间体钙调神经磷酸酶。由该基因编码的蛋白质功能类似于环孢菌素 A，与亲环素 B 结合并通过引起钙流入而作用于 TCR 下游和神经钙蛋白上游。这种完整的膜蛋白似乎是钙信号转导途径的新参与者，即使在没有环孢菌素的情况下，也表明亲环蛋白 B 参与钙信号传导。[RefSeq 提供，2008 年 7 月]

The immunosuppressant drug cyclosporin A blocks a calcium-dependent signal from the T-cell receptor (TCR) that normally leads to T-cell activation. When bound to Cyclophilin B, cyclosporin A binds and inactivates the key signaling intermediate Calcineurin. The protein encoded by this gene functions similarly to cyclosporin A, binding to Cyclophilin B and acting downstream of the TCR and upstream of Calcineurin by causing an influx of calcium. This integral membrane protein appears to be a new participant in the calcium signal transduction pathway, implicating Cyclophilin B in calcium signaling, even in the absence of cyclosporin. [provided by RefSeq, Jul 2008]