2. Gene
  3. ETNK1 - ethanolamine kinase 1 Gene

ETNK1 - ethanolamine kinase 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：乙醇胺激酶 1

种属: Homo sapiens

同用名: EKI; EKI1; EKI 1; Nbla10396

基因 ID: 55500 | 基因类型: protein coding

关于 ETNK1

Cytogenetic location: 12p12.1 Genomic coordinates (GRCh38): 12:22,625,171-22,690,665 (from NCBI)

This gene has 12 transcripts (splice variants), 209 orthologues, 3 paralogues and is associated with 61 phenotypes. Ubiquitous expression in stomach (RPKM 14.8), colon (RPKM 12.5) and 25 other tissues.

功能概要

该基因编码一种乙醇胺激酶，它在磷脂酰乙醇胺合成途径的第一步中发挥作用。这种胞质酶对乙醇胺具有特异性，对胆碱的激酶活性可忽略不计。可变剪接导致编码不同异构体的多个转录变体。[RefSeq 提供，2008 年 7 月]

This gene encodes an ethanolamine kinase, which functions in the first committed step of the phosphatidylethanolamine synthesis pathway. This cytosolic Enzyme is specific for ethanolamine and exhibits negligible kinase activity on choline. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

ETNK1 基因产物(2)

mRNA Protein Name
NM_001039481.2 NP_001034570.2 ethanolamine kinase 1 isoform B
NM_018638.5 NP_061108.3 ethanolamine kinase 1 isoform A
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ethanolamine kinase activity IDA
IDA: 通过直接分析推断
11044454 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
25416956 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in phosphatidylethanolamine biosynthetic process IDA
IDA: 通过直接分析推断
11044454 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in cytoplasm IDA
IDA: 通过直接分析推断
11044454 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ETNK1 蛋白结构

Choline_kinase

Choline_kinase: Choline/ethanolamine kinase (163 - 364)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 452 a.a.
蛋白主名 其他名称

ethanolamine kinase 1

putative protein product of Nbla10396

ETNK1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra ETNK1 Q9HBU6 UBQLN1 Homo sapiens Q9UMX0-2
Validated Y2H
25416956
Intra ETNK1 Q9HBU6 UBQLN1 Homo sapiens Q9UMX0-2
Y2H Array
25416956
Intra ETNK1 Q9HBU6 UBQLN1 Homo sapiens Q9UMX0-2
Y2H Prey Pooling
25416956
Intra ETNK1 Q9HBU6 SLC51B Homo sapiens Q86UW2
Y2H Prey Pooling
32296183
Intra ETNK1 Q9HBU6 SLC51B Homo sapiens Q86UW2
Y2H Array
32296183
Intra ETNK1 Q9HBU6 CAMLG Homo sapiens P49069
Y2H Prey Pooling
32296183
Intra ETNK1 Q9HBU6 CAMLG Homo sapiens P49069
Y2H Array
32296183
Intra ETNK1 Q9HBU6 SGTA Homo sapiens O43765
Y2H Array
32296183
Intra ETNK1 Q9HBU6 SGTA Homo sapiens O43765
Y2H Prey Pooling
32296183
Intra ETNK1 Q9HBU6 UBQLN1 Homo sapiens Q9UMX0
Validated Y2H
25416956
Intra ETNK1 Q9HBU6 UBQLN1 Homo sapiens Q9UMX0
Y2H Array
25416956
Intra ETNK1 Q9HBU6 SGTB Homo sapiens Q96EQ0
Y2H Prey Pooling
32296183
Intra ETNK1 Q9HBU6 SGTB Homo sapiens Q96EQ0
Y2H Array
32296183
Intra ETNK1 Q9HBU6 UBQLN2 Homo sapiens Q9UHD9
Validated Y2H
32296183
Intra ETNK1 Q9HBU6 UBQLN2 Homo sapiens Q9UHD9
Y2H Array
32296183
Intra ETNK1 Q9HBU6 UBQLN2 Homo sapiens Q9UHD9
Y2H Prey Pooling
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Atypical Chronic Myeloid Leukemia, Bcr-Abl1 Negative

Atypical Chronic Myeloid Leukemia

Atypical Chronic Myeloid Leukaemia

Leukemia, Myeloid, Chronic, Atypical, Bcr-Abl Negative

Acml

Atypical Chronic Myeloid Leukaemia Bcr-Abl1 Negative

Atypical Chronic Myeloid Leukemia Bcr-Abl1 Negative

Atypical Cml

Subacute Myeloid Leukemia

Subacute Myelogenous Leukaemia

Subacute Myeloid Leukaemia

Subacute Myelosis

Atypical Chronic Myeloid Leukaemia, Bcr-Abl-Negative Without Mention Of Remission

Subacute Monocytic Leukaemia Without Mention Of Remission

Subacute Monocytic Leukaemia
Myelodysplastic/Myeloproliferative Neoplasm

Myelodysplastic-Myeloproliferative Diseases

Myelodysplastic/Myeloproliferative Disease

Myelodysplastic Myeloproliferative Cancer

Myelodysplastic Myeloproliferative Disease

Myeloproliferative/Myelodysplastic Syndromes
Chronic Neutrophilic Leukemia

Cnl

Leukemia Neutrophilic Chronic
Bladder Neck Obstruction

Obstruction Of Bladder Neck Or Vesicourethral Orifice

Urinary Bladder Neck Obstruction

Bladder Outlet Obstruction

Vesicourethral Orifice Obstruction

Bno - [Bladder Neck Obstruction]

Bladder Obstruction Nos

Acquired Bladder Neck Obstruction

Acquired Obstruction Of Bladder Neck Or Vesicourethral Orifice

Bladder Neck Strangulation

Bladder Neck Stricture

Bladder Outflow Obstruction

Contracture Of Bladder Neck Or Sphincter

Contracture Of Bladder Neck

Obstructed Vesicourethral Orifice

Strangulation Of Vesicourethral Orifice

Stricture Of Vesicourethral Orifice

Urinary Prostatic Valve Obstruction

Vesical Obstruction
Chronic Leukemia

Adult Chronic Leukemia

Cll

Cml
Aggressive Systemic Mastocytosis

Asm

Lymphadenopathic Mastocytosis With Eosinophilia
Chronic Myelomonocytic Leukemia

Leukemia, Myelomonocytic, Chronic

Cmml

Leukemia Myelomonocytic Chronic

Cmml - [Chronic Myelomonocytic Leukaemia]

Chronic Myelomonocytic Leukaemia Without Mention Of Remission

Chronic Monocytic Leukaemia

Chronic Monocytoid Leukaemia
Juvenile Myelomonocytic Leukemia

Leukemia, Juvenile Myelomonocytic

JMML

Leukemia, Juvenile Myelomonocytic, Somatic

Juvenile Chronic Myelomonocytic Leukemia

Juvenile Chronic Myelogenous Leukemia

Leukemia, Myelomonocytic, Juvenile

Juvenile Myelomonocytic Leukaemia Without Mention Of Remission
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS04559 ETNK1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus ETNK1 VGNC VGNC:61978
Macaca mulatta ETNK1 VGNC VGNC:72329
Canis familiaris ETNK1 VGNC VGNC:40492
Rattus norvegicus ETNK1 RGD RGD:1308204
Mus musculus ETNK1 MGD MGI:1922570
Bos taurus ETNK1 VGNC VGNC:28624
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