PBXIP1 - PBX homeobox interacting protein 1 Gene

中文名称：PBX 同源框相互作用蛋白 1

种属: Homo sapiens

同用名: HPIP

基因 ID: 57326 | 基因类型: protein coding

关于 PBXIP1

Cytogenetic location: 1q21.3 Genomic coordinates (GRCh38): 1:154,944,080-154,956,099 (from NCBI)

This gene has 6 transcripts (splice variants) and 101 orthologues. Ubiquitous expression in ovary (RPKM 58.0), adrenal (RPKM 56.0) and 25 other tissues.

功能概要

该基因编码的蛋白质与 PBX1 同源结构域蛋白相互作用，通过阻止其与 DNA 结合来抑制其转录激活潜力。编码的蛋白质主要存在于细胞溶质中，但可以穿梭至细胞核，还可以与雌激素受体 α 和 β 相互作用，促进乳腺癌、脑肿瘤和肺癌的增殖。已发现该基因编码不同亚型的几种转录变体。存在更多变体，但它们的全长性质尚未确定。[RefSeq 提供，2015 年 12 月]

The protein encoded by this gene interacts with the PBX1 homeodomain protein, inhibiting its transcriptional activation potential by preventing its binding to DNA. The encoded protein, which is primarily cytosolic but can shuttle to the nucleus, also can interact with estrogen receptors alpha and beta and promote the proliferation of breast Cancer, brain tumors, and lung Cancer. Several transcript variants encoding different isoforms have been found for this gene. More variants exist, but their full-length natures have yet to be determined. [provided by RefSeq, Dec 2015]

PBXIP1 基因产物(3)

mRNA	Protein	Name
NM_001317734.2	NP_001304663.1	pre-B-cell leukemia transcription factor-interacting protein 1 isoform 2
NM_001317735.2	NP_001304664.1	pre-B-cell leukemia transcription factor-interacting protein 1 isoform 3
NM_020524.4	NP_065385.2	pre-B-cell leukemia transcription factor-interacting protein 1 isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables DNA-binding transcription factor binding	IPI IPI: 通过物理相互作用推断	10825160	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	16189514	GOA
enables transcription corepressor activity	IDA IDA: 通过直接分析推断	10825160	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in hemopoiesis	IEP IEP: 通过表达模式推断	10825160	GOA
involved in negative regulation of DNA-templated transcription	IDA IDA: 通过直接分析推断	10825160	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytosol	IDA IDA: 通过直接分析推断	10825160	GOA
located in nucleus	IDA IDA: 通过直接分析推断	10825160	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

蛋白主名

其他名称

pre-B-cell leukemia transcription factor-interacting protein 1

hematopoietic PBX-interacting protein

PBXIP1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	PBXIP1	Q96AQ6	FLJ13057	Homo sapiens	Q53SE7	Y2H Prey Pooling	25416956
种属内	PBXIP1	Q96AQ6	UBQLN1	Homo sapiens	Q9UMX0-2	Y2H Array	25416956
种属内	PBXIP1	Q96AQ6	MORF4L1	Homo sapiens	Q9UBU8-2	Y2H Array	25416956
种属内	PBXIP1	Q96AQ6	MORF4L1	Homo sapiens	Q9UBU8-2	Y2H Prey Pooling	25416956
种属内	PBXIP1	Q96AQ6	KRTAP10-6	Homo sapiens	P60371	Y2H Prey Pooling	32296183
种属内	PBXIP1	Q96AQ6	KRTAP10-6	Homo sapiens	P60371	Y2H Array	32296183
种属内	PBXIP1	Q96AQ6	CAMLG	Homo sapiens	P49069	Y2H Array	32296183
种属内	PBXIP1	Q96AQ6	CAMLG	Homo sapiens	P49069	Y2H Prey Pooling	32296183
种属内	PBXIP1	Q96AQ6	GMCL1	Homo sapiens	Q96IK5	Anti Tag CoIP	33961781
种属内	PBXIP1	Q96AQ6	GMCL1	Homo sapiens	Q96IK5	Y2H Prey Pooling	32296183
种属内	PBXIP1	Q96AQ6	GMCL1	Homo sapiens	Q96IK5	Validated Y2H	32296183
种属内	PBXIP1	Q96AQ6	GMCL1	Homo sapiens	Q96IK5	Y2H Array	32296183
种属内	PBXIP1	Q96AQ6	CCNC	Homo sapiens	P24863	Anti Tag CoIP	33961781
种属内	PBXIP1	Q96AQ6	CCNC	Homo sapiens	P24863	Validated Y2H	25416956
种属内	PBXIP1	Q96AQ6	CCNC	Homo sapiens	P24863	Y2H Prey Pooling	25416956
种属内	PBXIP1	Q96AQ6	CCNC	Homo sapiens	P24863	Y2H Array	25416956
种属内	PBXIP1	Q96AQ6	MORF4L1	Homo sapiens	Q9UBU8	Y2H Array	25416956
种属内	PBXIP1	Q96AQ6	MORF4L1	Homo sapiens	Q9UBU8	Y2H Prey Pooling	25416956
种属内	PBXIP1	Q96AQ6	WASHC3	Homo sapiens	Q9Y3C0	Y2H Array	31515488
种属内	PBXIP1	Q96AQ6	WASHC3	Homo sapiens	Q9Y3C0	Y2H Pooling	19060904
种属内	PBXIP1	Q96AQ6	WASHC3	Homo sapiens	Q9Y3C0	Y2H Array	19060904
种属内	PBXIP1	Q96AQ6	DEF6	Homo sapiens	Q9H4E7	Validated Y2H	25416956
种属内	PBXIP1	Q96AQ6	DEF6	Homo sapiens	Q9H4E7	Y2H Array	25416956
种属内	PBXIP1	Q96AQ6	GABARAPL1	Homo sapiens	Q9H0R8	Validated Y2H	32296183
种属内	PBXIP1	Q96AQ6	DAXX	Homo sapiens	Q9UER7	Validated Y2H	25416956
种属内	PBXIP1	Q96AQ6	DAXX	Homo sapiens	Q9UER7	Y2H Array	25416956
种属内	PBXIP1	Q96AQ6	DAXX	Homo sapiens	Q9UER7	Y2H Prey Pooling	25416956
种属内	PBXIP1	Q96AQ6	LCA5L	Homo sapiens	O95447	Y2H Array	32296183
种属内	PBXIP1	Q96AQ6	LCA5L	Homo sapiens	O95447	Y2H Prey Pooling	32296183
种属内	PBXIP1	Q96AQ6	PPTC7	Homo sapiens	Q8NI37	Y2H Array	32296183
种属内	PBXIP1	Q96AQ6	PPTC7	Homo sapiens	Q8NI37	Y2H Prey Pooling	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Leukemia

Leukemias	Leukaemia, Unspecified, Without Mention Of Remission
Aleukemic Leukaemia	Chronic Leukaemia
Subacute Leukaemia	Leukaemia Disorder
Leukaemia Nos

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS10110	PBXIP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	PBXIP1	RGD	RGD:1305180
Bos taurus	PBXIP1	VGNC	VGNC:32611
Macaca mulatta	PBXIP1	VGNC	VGNC:75663
Felis catus	PBXIP1	VGNC	VGNC:103739
Mus musculus	PBXIP1	MGD	MGI:2441670
Canis familiaris	PBXIP1	VGNC	VGNC:44290

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

PBXIP1 - PBX homeobox interacting protein 1 Gene

关于 PBXIP1

功能概要

PBXIP1 基因产物(3)

PBXIP1 蛋白互作信息

关联疾病

直系同源

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PBXIP1 - PBX homeobox interacting protein 1 Gene

关于 PBXIP1

功能概要

PBXIP1 基因产物(3)

PBXIP1 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z