2. Gene
  3. PRB3 - proline rich protein BstNI subfamily 3 Gene

PRB3 - proline rich protein BstNI subfamily 3 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：富脯氨酸蛋白 BstNI 亚家族 3

种属: Homo sapiens

同用名: G1; PRG

基因 ID: 5544 | 基因类型: protein coding

关于 PRB3

Cytogenetic location: 12p13.2 Genomic coordinates (GRCh38): 12:11,265,914-11,269,707 (from NCBI)

This gene has 3 transcripts (splice variants), 1 gene allele, 4 orthologues and 6 paralogues. Restricted expression toward salivary gland (RPKM 9550.6).

功能概要

该基因编码基本的、富含脯氨酸的人类唾液糖蛋白异质家族的成员。已经鉴定出该基因的多个等位基因在串联重复序列的长度上表现出变化。参考基因组编码“Long”等位基因。由该基因编码的蛋白质亚型被认为是抵御饮食中多酚和病原体感染的有害影响的“第一道口腔防线”。该基因位于 12 号染色体上一组密切相关的富含脯氨酸的唾液蛋白中。[RefSeq 提供，2015 年 11 月]

This gene encodes a member of the heterogeneous family of basic, proline-rich, human salivary glycoproteins. Multiple alleles of this gene exhibiting variations in the length of the tandem repeats have been identified. The reference genome encodes the "Long" allele. The protein isoforms encoded by this gene are recognized as the "first line of oral defense" against the detrimental effects of Polyphenols in the diet and pathogen infections. This gene is located in a cluster of closely related salivary proline-rich proteins on chromosome 12. [provided by RefSeq, Nov 2015]

PRB3 基因产物(2)

mRNA Protein Name
NM_001394862.1 NP_001381791.1 basic salivary proline-rich protein 3 isoform 2 precursor
NM_006249.5 NP_006240.4 basic salivary proline-rich protein 3 isoform 1 precursor
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PRB3 蛋白结构

Pro-rich

Pro-rich: Proline-rich (1 - 136)

Pro-rich

Pro-rich: Proline-rich (109 - 182)

Pro-rich

Pro-rich: Proline-rich (173 - 243)

Pro-rich

Pro-rich: Proline-rich (217 - 304)

  • 0
  • 100
  • 200
  • 309 a.a.
蛋白主名 其他名称

basic salivary proline-rich protein 3

BstNI type basic salivary proline-rich protein 3

PRB3 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra PRB3 Q04118 SH3GL1 Homo sapiens Q99961
Validated Y2H
32296183
Intra PRB3 Q04118 TBRG4 Homo sapiens Q969Z0
Validated Y2H
32296183
Intra PRB3 Q04118 PBX3 Homo sapiens Q96AL5
Validated Y2H
32296183
Intra PRB3 Q04118 SGTB Homo sapiens Q96EQ0
Validated Y2H
32296183
Intra PRB3 Q04118 SGTB Homo sapiens Q96EQ0
Y2H Prey Pooling
32296183
Intra PRB3 Q04118 SGTB Homo sapiens Q96EQ0
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Head And Neck Cancer

Head And Neck Neoplasm

Head And Neck Tumours

Head/Neck Neoplasm

Tumor Of Head And Neck

Head And Neck Neoplasms

Hnc

Cancer, Head/Neck
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-168660 CPD-10 / 否
HY-RS11053 PRB3 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus PRB3 RGD RGD:620386
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