1. Gene
  2. SNAPC5 - small nuclear RNA activating complex polypeptide 5 Gene

SNAPC5 - small nuclear RNA activating complex polypeptide 5 Gene

中文名称:小核 RNA 激活复合多肽 5

种属: Homo sapiens

同用名: SNAP19

基因 ID: 10302 | 基因类型: protein coding

关于 SNAPC5

Cytogenetic location: 15q22.31 Genomic coordinates (GRCh38): 15:66,489,748-66,497,762 (from NCBI)

This gene has 8 transcripts (splice variants) and 183 orthologues. Ubiquitous expression in brain (RPKM 30.5), fat (RPKM 21.0) and 25 other tissues.

功能概要

该基因编码小核 RNA (snRNA) 激活蛋白复合物的一个亚基,该复合物在 snRNA 基因的转录中发挥作用。该复合物与 RNA 聚合酶 II 或 III 转录的 snRNA 基因的启动子结合,并招募其他调节因子来激活 snRNA 基因转录。编码的蛋白质可能在稳定这种复合物方面发挥作用。已在 6 号染色体上鉴定出该基因的假基因。[RefSeq 提供,2016 年 7 月]

This gene encodes a subunit of the small nuclear RNA (snRNA)-activating protein complex that plays a role in the transcription of snRNA genes. This complex binds to the promoters of snRNA genes transcribed by either RNA polymerase II or III and recruits Other regulatory factors to activate snRNA gene transcription. The encoded protein may play a role in stabilizing this complex. A pseudogene of this gene has been identified on chromosome 6. [provided by RefSeq, Jul 2016]

SNAPC5 基因产物(4)

mRNA Protein Name
NM_001329613.2 NP_001316542.1 snRNA-activating protein complex subunit 5 isoform 2
NM_001329614.2 NP_001316543.1 snRNA-activating protein complex subunit 5 isoform 3
NM_001329615.2 NP_001316544.1 snRNA-activating protein complex subunit 5 isoform 1
NM_006049.4 NP_006040.1 snRNA-activating protein complex subunit 5 isoform 1
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables RNA polymerase II general transcription initiation factor activity IDA
IDA: 通过直接分析推断
9732265 GOA
enables RNA polymerase III general transcription initiation factor activity IDA
IDA: 通过直接分析推断
9732265 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
11056176 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in snRNA transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
9732265 GOA
involved in snRNA transcription by RNA polymerase III IDA
IDA: 通过直接分析推断
9732265 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

SNAPC5 蛋白结构

SNAPc19

SNAPc19: snRNA-activating protein complex subunit 19, SNAPc subunit 19 (7 - 97)

  • 0
  • 98 a.a.
蛋白主名 其他名称

snRNA-activating protein complex subunit 5

SNAPc 19 kDa subunit

SNAPC5 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
SNAPC5 O75971 DDIT3 Homo sapiens P35638-2
Validated Y2H
25416956
种属内
SNAPC5 O75971 NOL4 Homo sapiens O94818-2
Validated Y2H
25416956
种属内
SNAPC5 O75971 NUP62 Homo sapiens P37198
Y2H Prey Pooling
25416956
种属内
SNAPC5 O75971 NMI Homo sapiens Q13287
Validated Y2H
25416956
种属内
SNAPC5 O75971 NMI Homo sapiens Q13287
Y2H Array
25416956
种属内
SNAPC5 O75971 NMI Homo sapiens Q13287
Y2H
21516116
种属内
SNAPC5 O75971 NMI Homo sapiens Q13287
Y2H Prey Pooling
25416956
种属内
SNAPC5 O75971 AMOT Homo sapiens Q4VCS5-2
Y2H Prey Pooling
25416956
种属内
SNAPC5 O75971 NUDT10 Homo sapiens Q8NFP7
Validated Y2H
25416956
种属内
SNAPC5 O75971 NUDT10 Homo sapiens Q8NFP7
Y2H Array
25416956
种属内
SNAPC5 O75971 ZNRD2 Homo sapiens O60232
Y2H Array
25416956
种属内
SNAPC5 O75971 ZNRD2 Homo sapiens O60232
Validated Y2H
25416956
种属内
SNAPC5 O75971 NDEL1 Homo sapiens Q9GZM8
Y2H Prey Pooling
25416956
种属内
SNAPC5 O75971 NDEL1 Homo sapiens Q9GZM8
Y2H Array
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Melanoma

Malignant Melanoma

Cutaneous Melanoma

Naevocarcinoma

Malignant Melanomas

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Bos taurus SNAPC5 VGNC VGNC:35057
Rattus norvegicus SNAPC5 RGD RGD:1582813
Felis catus SNAPC5 VGNC VGNC:65523
Macaca mulatta SNAPC5 VGNC VGNC:77712
Mus musculus SNAPC5 MGD MGI:1914282
Canis familiaris SNAPC5 VGNC VGNC:46594