RASAL3 - RAS protein activator like 3 Gene

中文名称：RAS 蛋白激活因子样 3

种属: Homo sapiens

关于 RASAL3

功能概要

该基因属于 Ras GTP 酶激活蛋白 (RasGAP) 家族，编码具有 pleckstrin 同源性 (PH) 、C2 和 Ras GTP 酶激活蛋白 (RasGAP) 结构域的蛋白质。当外源表达时，该蛋白质位于质膜附近或质膜处。该基因在某些细胞系中的表达减少导致 Ras 活性形式 (Ras-GTP) 水平升高，表明该基因可能在负向调节 Ras 信号通路中发挥作用。可变剪接导致编码不同异构体的多个转录变体。[RefSeq 提供，2017 年 1 月]

This gene belongs to the Ras GTPase-activating proteins (RasGAP) family and encodes a protein with pleckstrin homology (PH), C2, and Ras GTPase-activation protein (RasGAP) domains. This protein is localized near or at the plasma membrane when expressed exogenously. Reduced expression of this gene in some cell lines resulted in increased levels of the active form of Ras (Ras-GTP), suggesting that this gene may play a role in negatively regulating the Ras signaling pathway. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2017]