RASD1 - ras related dexamethasone induced 1 Gene

中文名称：ras 相关地塞米松诱导 1

种属: Homo sapiens

同用名: AGS1; DEXRAS1; MGC:26290

关于 RASD1

功能概要

该基因编码小 GTP 酶 Ras 超家族的成员，并由地塞米松诱导。编码的蛋白质是 G 蛋白信号的激活剂，并作为 Gi-Go 蛋白的直接核苷酸交换因子。这种蛋白质与神经元一氧化氮衔接蛋白 CAPON 和核衔接蛋白 FE65 相互作用，后者与阿尔茨海默病淀粉样蛋白前体蛋白相互作用。该基因可能在地塞米松诱导的细胞形态、生长和细胞-细胞外基质相互作用的改变中发挥作用。该基因的表观遗传失活与多发性骨髓瘤细胞对地塞米松的耐药性密切相关。已发现该基因编码不同亚型的可变剪接转录变体。[RefSeq 提供，2011 年 9 月]

This gene encodes a member of the Ras superfamily of small GTPases and is induced by dexamethasone. The encoded protein is an activator of G-protein signaling and acts as a direct nucleotide exchange factor for Gi-Go proteins. This protein interacts with the neuronal nitric oxide adaptor protein CAPON, and a nuclear adaptor protein FE65, which interacts with the Alzheimer's disease amyloid precursor protein. This gene may play a role in dexamethasone-induced alterations in cell morphology, growth and cell-extracellular matrix interactions. Epigenetic inactivation of this gene is closely correlated with resistance to dexamethasone in multiple myeloma cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2011]