PTPN21 - protein tyrosine phosphatase non-receptor type 21 Gene

中文名称：蛋白酪氨酸磷酸酶非受体 21 型

种属: Homo sapiens

同用名: PTPD1; PTPRL10

关于 PTPN21

功能概要

该基因编码的蛋白质是蛋白酪氨酸磷酸酶 (PTP) 家族的成员。已知 PTP 是调节多种细胞过程的信号分子，包括细胞生长、分化、有丝分裂周期和致癌转化。该 PTP 包含一个 N 末端结构域，类似于细胞骨架相关蛋白，包括带 4.1、ezrin、merlin 和 radixin。该 PTP 显示与 BMX/ETK 特殊相互作用，BMX/ETK 是 Tec 酪氨酸激酶家族的成员，其特征在于包括 PH、SH3 和 SH2 结构域在内的多模块结构。发现该 PTP 与 BMX 激酶的相互作用会增加 STAT3 的激活，但不会增加 STAT2 激酶。对小鼠中相似基因的研究表明，这种 PTP 在肝再生和精子发生中可能发挥作用。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is a member of the protein tyrosine Phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal domain, similar to cytoskeletal- associated proteins including band 4.1, ezrin, merlin, and radixin. This PTP was shown to specially interact with BMX/ETK, a member of Tec tyrosine kinase family characterized by a multimodular structures including PH, SH3, and SH2 domains. The interaction of this PTP with BMX Kinase was found to increase the activation of STAT3, but not STAT2 kinase. Studies of the similar gene in mice suggested the possible roles of this PTP in liver regeneration and spermatogenesis. [provided by RefSeq, Jul 2008]