2. Gene
  3. CWC22 - CWC22 spliceosome associated protein homolog Gene

CWC22 - CWC22 spliceosome associated protein homolog Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：CWC22 剪接体相关蛋白同系物

种属: Homo sapiens

同用名: NCM; fSAPb; EIF4GL

基因 ID: 57703 | 基因类型: protein coding

关于 CWC22

Cytogenetic location: 2q31.3 Genomic coordinates (GRCh38): 2:179,944,876-180,007,297 (from NCBI)

This gene has 2 transcripts (splice variants), 229 orthologues and 1 paralogue. Ubiquitous expression in lymph node (RPKM 9.1), thyroid (RPKM 8.8) and 25 other tissues.

功能概要

启用 RNA 结合活性。通过剪接体参与 mRNA 剪接。位于胞质溶胶和核斑点。 U2 型催化步骤 1 剪接体的一部分； U2 型催化步骤 2 剪接体；和 U2 型预催化剪接体。 [由基因组资源联盟提供，2022 年 4 月]

Enables RNA binding activity. Involved in mRNA splicing, via spliceosome. Located in cytosol and nuclear speck. Part of U2-type catalytic step 1 spliceosome; U2-type catalytic step 2 spliceosome; and U2-type precatalytic spliceosome. [provided by Alliance of Genome Resources, Apr 2022]

CWC22 基因产物(5)

mRNA Protein Name
NM_001376029.1 NP_001362958.1 pre-mRNA-splicing factor CWC22 homolog isoform a
NM_001376030.1 NP_001362959.1 pre-mRNA-splicing factor CWC22 homolog isoform a
NM_001376032.1 NP_001362961.1 pre-mRNA-splicing factor CWC22 homolog isoform b
NM_001376033.1 NP_001362962.1 pre-mRNA-splicing factor CWC22 homolog isoform c
NM_020943.3 NP_065994.1 pre-mRNA-splicing factor CWC22 homolog isoform a
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables RNA binding IDA
IDA: 通过直接分析推断
11991638 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
22365833 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in mRNA splicing, via spliceosome IDA
IDA: 通过直接分析推断
29360106 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of U2-type catalytic step 1 spliceosome IDA
IDA: 通过直接分析推断
29301961 GOA
part of U2-type catalytic step 2 spliceosome IDA
IDA: 通过直接分析推断
28076346 GOA
part of U2-type precatalytic spliceosome IDA
IDA: 通过直接分析推断
29360106 GOA
part of catalytic step 2 spliceosome IDA
IDA: 通过直接分析推断
11991638 GOA
located in nuclear speck IDA
IDA: 通过直接分析推断
22961380 GOA
located in nucleus IDA
IDA: 通过直接分析推断
29360106 GOA
part of spliceosomal complex IDA
IDA: 通过直接分析推断
11991638 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CWC22 蛋白结构

MIF4G

MIF4G: MIF4G domain (164 - 345)

MA3

MA3: MA3 domain (455 - 561)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 908 a.a.
蛋白主名 其他名称

pre-mRNA-splicing factor CWC22 homolog

CWC22 homolog, spliceosome-associated protein

CWC22 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
CWC22 Q9HCG8 FRG1 Homo sapiens Q14331
Y2H
22365833
种属内
CWC22 Q9HCG8 PTPN21 Homo sapiens Q16825
Y2H Array
32296183
种属内
CWC22 Q9HCG8 PTPN21 Homo sapiens Q16825
Y2H Prey Pooling
32296183
种属内
CWC22 Q9HCG8 EIF4A3 Homo sapiens P38919
Y2H
22365833
种属内
CWC22 Q9HCG8 FAM32A Homo sapiens Q9Y421
Anti Tag CoIP
22365833
种属内
CWC22 Q9HCG8 KLHL2 Homo sapiens O95198
Y2H Prey Pooling
32296183
种属内
CWC22 Q9HCG8 KLHL2 Homo sapiens O95198
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Hard Palate Cancer

Malignant Neoplasm Of Hard Palate

Malignant Tumor Of Hard Palate

Malignant Tumour Of Hard Palate
Mucinous Cystadenocarcinoma Of Pancreas

Pancreatic Mucinous Cystadenocarcinoma

Mucinous Cystadenocarcinoma Of The Pancreas

Pancreatic Colloid Cystadenocarcinoma
Pancreatic Cystadenocarcinoma

Cystadenocarcinoma Of Pancreas
Diabetic Polyneuropathy

Diabetes Mellitus With Polyneuropathy

Polyneuropathy In Diabetes

Diabetic Polyneuropathies

Diabetic Neuropathy Nos
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS03373 CWC22 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus CWC22 VGNC VGNC:61291
Canis familiaris CWC22 VGNC VGNC:39741
Macaca mulatta CWC22 VGNC VGNC:71604
Mus musculus CWC22 MGD MGI:2136773
Rattus norvegicus CWC22 RGD RGD:1565385
Bos taurus CWC22 VGNC VGNC:27841
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