2. Gene
  3. SNX18 - sorting nexin 18 Gene

SNX18 - sorting nexin 18 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：排序 nexin 18

种属: Homo sapiens

同用名: SNAG1; SH3PX2; SH3PXD3B

基因 ID: 112574 | 基因类型: protein coding

关于 SNX18

This gene has 3 transcripts (splice variants), 271 orthologues and 15 paralogues. Ubiquitous expression in bone marrow (RPKM 13.6), ovary (RPKM 10.4) and 25 other tissues.

功能概要

该基因编码分选连接蛋白家族的一个成员。该家族的成员包含一个 phox (PX) 结构域，它是一个磷酸肌醇结合结构域，并参与细胞内运输。该蛋白质不像某些家族成员那样包含卷曲螺旋区域，但包含 SH3 结构域。已发现该基因编码不同异构体的多个转录变体。[RefSeq 提供，2008 年 7 月]

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members, but contains a SH3 domain. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

SNX18 基因产物(3)

mRNA Protein Name
NM_001102575.2 NP_001096045.1 sorting nexin-18 isoform a
NM_001145427.2 NP_001138899.1 sorting nexin-18 isoform c
NM_052870.4 NP_443102.2 sorting nexin-18 isoform b
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables phosphatidylinositol-4,5-bisphosphate binding IDA
IDA: 通过直接分析推断
23878278 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
20427313 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cleavage furrow formation IMP
IMP: 通过突变表型推断
22718350 GOA
involved in endocytosis IDA
IDA: 通过直接分析推断
20427313 GOA
involved in endocytosis IMP
IMP: 通过突变表型推断
22718350 GOA
involved in endosomal transport IMP
IMP: 通过突变表型推断
22718350 GOA
involved in mitotic cytokinesis IMP
IMP: 通过突变表型推断
22718350 GOA
involved in positive regulation of GTPase activity IDA
IDA: 通过直接分析推断
20427313 GOA
involved in positive regulation of autophagosome assembly IMP
IMP: 通过突变表型推断
29437695 GOA
involved in protein transport IMP
IMP: 通过突变表型推断
29437695 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
colocalizes with clathrin-coated vesicle IDA
IDA: 通过直接分析推断
20427313 GOA
located in cytoplasmic side of plasma membrane IDA
IDA: 通过直接分析推断
20427313 GOA
located in cytoplasmic vesicle IDA
IDA: 通过直接分析推断
22718350 GOA
located in extracellular exosome IDA
IDA: 通过直接分析推断
15326289 GOA
is active in recycling endosome membrane IMP
IMP: 通过突变表型推断
29437695 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SNX18 蛋白结构

SH3_9

SH3_9: Variant SH3 domain (7 - 57)

PX

PX: PX domain (278 - 380)

BAR_3_WASP_bdg

BAR_3_WASP_bdg: WASP-binding domain of Sorting nexin protein (386 - 541)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 628 a.a.
蛋白主名 其他名称

sorting nexin-18

SH3 and PX domain-containing protein 3B

SNX18 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra SNX18 Q96RF0 ABI2 Homo sapiens Q9NYB9-2
Validated Y2H
32296183
Intra SNX18 Q96RF0 ABI2 Homo sapiens Q9NYB9-2
Y2H Array
32296183
Intra SNX18 Q96RF0 ABI2 Homo sapiens Q9NYB9-2
Y2H Prey Pooling
32296183
Intra SNX18 Q96RF0 CPSF7 Homo sapiens Q8N684-3
Y2H Prey Pooling
32296183
Intra SNX18 Q96RF0 CPSF7 Homo sapiens Q8N684-3
Y2H Array
32296183
Intra SNX18 Q96RF0 MSS51 Homo sapiens Q4VC12
Y2H Array
32296183
Intra SNX18 Q96RF0 MSS51 Homo sapiens Q4VC12
Y2H Prey Pooling
32296183
Intra SNX18 Q96RF0 KRTAP1-1 Homo sapiens Q07627
Y2H Prey Pooling
32296183
Intra SNX18 Q96RF0 KRTAP1-1 Homo sapiens Q07627
Y2H Array
32296183
Intra SNX18 Q96RF0 ZBTB42 Homo sapiens B2RXF5
Y2H Array
32296183
Intra SNX18 Q96RF0 ZBTB42 Homo sapiens B2RXF5
Y2H Prey Pooling
32296183
Intra SNX18 Q96RF0 RAB11FIP5 Homo sapiens Q9BXF6
Pull Down
24591568
Intra SNX18 Q96RF0 KRTAP6-3 Homo sapiens Q3LI67
Y2H Prey Pooling
32296183
Intra SNX18 Q96RF0 KRTAP6-3 Homo sapiens Q3LI67
Y2H Array
32296183
Intra SNX18 Q96RF0 PTPN21 Homo sapiens Q16825
Y2H Prey Pooling
32296183
Intra SNX18 Q96RF0 PTPN21 Homo sapiens Q16825
Y2H Array
32296183
Intra SNX18 Q96RF0 CYSRT1 Homo sapiens A8MQ03
Y2H Array
32296183
Intra SNX18 Q96RF0 CYSRT1 Homo sapiens A8MQ03
Y2H Prey Pooling
32296183
Intra SNX18 Q96RF0 GOLGA2 Homo sapiens Q08379
Y2H Array
32296183
Intra SNX18 Q96RF0 GOLGA2 Homo sapiens Q08379
Y2H Prey Pooling
32296183
Intra SNX18 Q96RF0 DPPA4 Homo sapiens Q7L190
Validated Y2H
32296183
Intra SNX18 Q96RF0 DPPA4 Homo sapiens Q7L190
Y2H Array
32296183
Intra SNX18 Q96RF0 DPPA4 Homo sapiens Q7L190
Y2H Prey Pooling
32296183
Intra SNX18 Q96RF0 HSF2BP Homo sapiens O75031
Y2H Array
32296183
Intra SNX18 Q96RF0 HSF2BP Homo sapiens O75031
Y2H Prey Pooling
32296183
Intra SNX18 Q96RF0 KHDRBS3 Homo sapiens O75525
Y2H Array
32296183
Intra SNX18 Q96RF0 KHDRBS3 Homo sapiens O75525
Y2H Prey Pooling
32296183
Intra SNX18 Q96RF0 MDFI Homo sapiens Q99750
Y2H Array
32296183
Intra SNX18 Q96RF0 MDFI Homo sapiens Q99750
Y2H Prey Pooling
32296183
Intra SNX18 Q96RF0 MDFI Homo sapiens Q99750
Validated Y2H
32296183
Intra SNX18 Q96RF0 HSPB2 Homo sapiens Q16082
Y2H Prey Pooling
32296183
Intra SNX18 Q96RF0 HSPB2 Homo sapiens Q16082
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS13531 SNX18 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus SNX18 MGD MGI:2137642
Canis familiaris SNX18 VGNC VGNC:46627
Macaca mulatta SNX18 VGNC VGNC:77738
Felis catus SNX18 VGNC VGNC:65548
Rattus norvegicus SNX18 RGD RGD:1310367
Bos taurus SNX18 VGNC VGNC:35098
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