PAK5 - p21 (RAC1) activated kinase 5 Gene

中文名称：p21 (RAC1) 激活激酶 5

种属: Homo sapiens

同用名: PAK7

关于 PAK5

功能概要

该基因编码的蛋白质是 Ser/Thr 蛋白激酶 PAK 家族的成员。已知 PAK 家族成员是 Rac/Cdc42 GTP 酶的效应子，其与细胞骨架动力学、增殖和细胞存活信号的调节有关。该激酶包含 CDC42/Rac1 交互结合 (CRIB) 基序，并且已显示在 GTP 存在的情况下结合 CDC42。这种激酶主要在脑中表达。它能够促进神经突生长，因此可能在神经突发育中发挥作用。该激酶与微管网络相关并诱导微管稳定。这种激酶的亚细胞定位在细胞周期进程中受到严格调控。已经描述了编码相同蛋白质的可变剪接转录物变体。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is a member of the PAK family of Ser/Thr protein kinases. PAK family members are known to be effectors of Rac/Cdc42 GTPases, which have been implicated in the regulation of cytoskeletal dynamics, proliferation, and cell survival signaling. This kinase contains a CDC42/Rac1 interactive binding (CRIB) motif, and has been shown to bind CDC42 in the presence of GTP. This kinase is predominantly expressed in brain. It is capable of promoting neurite outgrowth, and thus may play a role in neurite development. This kinase is associated with microtubule networks and induces microtubule stabilization. The subcellular localization of this kinase is tightly regulated during cell cycle progression. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]