2. Gene
  3. UXT - ubiquitously expressed prefoldin like chaperone Gene

UXT - ubiquitously expressed prefoldin like chaperone Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：普遍表达的前折叠蛋白样伴侣

种属: Homo sapiens

同用名: STAP1; ART-27

基因 ID: 8409 | 基因类型: protein coding

关于 UXT

Cytogenetic location: Xp11.23 Genomic coordinates (GRCh38): X:47,651,796-47,659,180 (from NCBI)

This gene has 5 transcripts (splice variants) and 181 orthologues. Ubiquitous expression in bone marrow (RPKM 37.8), ovary (RPKM 37.2) and 25 other tissues.

功能概要

由该基因编码的蛋白质作为调节雄激素受体依赖性转录的辅助因子发挥作用，并且还在肿瘤坏死因子诱导的细胞凋亡中发挥关键作用。该基因的表达可能在肿瘤发生中起作用。已经观察到该基因编码多种亚型的可变剪接转录物变体。[RefSeq 提供，2011 年 11 月]

The protein encoded by this gene functions as a cofactor that modulates androgen receptor-dependent transcription, and also plays a critical role in tumor necrosis factor-induced Apoptosis. Expression of this gene may play a role in tumorigenesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]

UXT 基因产物(2)

mRNA Protein Name
NM_004182.4 NP_004173.1 protein UXT isoform 2
NM_153477.3 NP_705582.1 protein UXT isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
NOT enables actin filament binding IDA
IDA: 通过直接分析推断
12762840 GOA
enables beta-tubulin binding IDA
IDA: 通过直接分析推断
12762840 GOA
enables chromatin binding IDA
IDA: 通过直接分析推断
21730289 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
12762840 GOA
enables transcription corepressor activity IDA
IDA: 通过直接分析推断
21730289 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in centrosome cycle IMP
IMP: 通过突变表型推断
16221885 GOA
involved in microtubule cytoskeleton organization IMP
IMP: 通过突变表型推断
16221885 GOA
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
21730289 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of RPAP3/R2TP/prefoldin-like complex IPI
IPI: 通过物理相互作用推断
31738558 GOA
located in centrosome IDA
IDA: 通过直接分析推断
16221885 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
21730289 GOA
located in cytoskeleton IDA
IDA: 通过直接分析推断
12762840 GOA
located in nucleus IDA
IDA: 通过直接分析推断
12762840 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

UXT 蛋白结构

Prefoldin

Prefoldin: Prefoldin subunit (29 - 146)

  • 0
  • 100
  • 157 a.a.
蛋白主名 其他名称

protein UXT

SKP2-associated alpha PFD 1

UXT 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra UXT Q9UBK9 KRT40 Homo sapiens Q6A162
Y2H Prey Pooling
25416956
Intra UXT Q9UBK9 KRT40 Homo sapiens Q6A162
Validated Y2H
25416956
Intra UXT Q9UBK9 KRT40 Homo sapiens Q6A162
Y2H Array
25416956
Intra UXT Q9UBK9 KRTAP10-8 Homo sapiens P60410
Y2H Prey Pooling
32296183
Intra UXT Q9UBK9 KRTAP10-8 Homo sapiens P60410
Y2H Array
32296183
Intra UXT Q9UBK9 KRTAP10-7 Homo sapiens P60409
Y2H Prey Pooling
25416956
Intra UXT Q9UBK9 KRTAP10-7 Homo sapiens P60409
Validated Y2H
25416956
Intra UXT Q9UBK9 KRTAP10-7 Homo sapiens P60409
Y2H Array
25416956
Intra UXT Q9UBK9 KRTAP1-3 Homo sapiens Q8IUG1
Y2H Array
32296183
Intra UXT Q9UBK9 KRTAP1-3 Homo sapiens Q8IUG1
Y2H Prey Pooling
32296183
Intra UXT Q9UBK9 DYNLT1 Homo sapiens P63172
Y2H Prey Pooling
32296183
Intra UXT Q9UBK9 DYNLT1 Homo sapiens P63172
Y2H Array
32296183
Intra UXT Q9UBK9 KRTAP12-3 Homo sapiens P60328
Y2H Array
32296183
Intra UXT Q9UBK9 KRTAP12-3 Homo sapiens P60328
Y2H Prey Pooling
32296183
Intra UXT Q9UBK9 KRTAP5-7 Homo sapiens Q6L8G8
Y2H Array
32296183
Intra UXT Q9UBK9 KRTAP5-7 Homo sapiens Q6L8G8
Y2H Prey Pooling
32296183
Intra UXT Q9UBK9 MECOM Homo sapiens Q03112
Y2H
17635584
Intra UXT Q9UBK9 MECOM Homo sapiens Q03112
Pull Down
17635584
Intra UXT Q9UBK9 MECOM Homo sapiens Q03112
Anti Tag CoIP
17635584
Intra UXT Q9UBK9 NOTCH2NLC Homo sapiens P0DPK4
Y2H Prey Pooling
32296183
Intra UXT Q9UBK9 NOTCH2NLC Homo sapiens P0DPK4
Y2H Array
32296183
Intra UXT Q9UBK9 RPAP3 Homo sapiens Q9H6T3
Anti Tag CoIP
33961781
Intra UXT Q9UBK9 RPAP3 Homo sapiens Q9H6T3
Lumier
25036637
Intra UXT Q9UBK9 PFDN2 Homo sapiens Q9UHV9
Lumier
25036637
Intra UXT Q9UBK9 KRTAP5-9 Homo sapiens P26371
Y2H Array
32296183
Intra UXT Q9UBK9 KRTAP5-9 Homo sapiens P26371
Y2H Prey Pooling
32296183
Intra UXT Q9UBK9 RELA Homo sapiens Q04206
Anti Bait CoIP
17620405
Intra UXT Q9UBK9 PAK5 Homo sapiens Q9P286
Y2H Prey Pooling
25416956
Intra UXT Q9UBK9 PAK5 Homo sapiens Q9P286
Y2H Array
31515488
Intra UXT Q9UBK9 PAK5 Homo sapiens Q9P286
Y2H Array
25416956
Intra UXT Q9UBK9 SIAH1 Homo sapiens Q8IUQ4
Y2H Prey Pooling
25416956
Intra UXT Q9UBK9 SIAH1 Homo sapiens Q8IUQ4
Validated Y2H
25416956
Intra UXT Q9UBK9 SARM1 Homo sapiens Q0D2N8
Y2H
24021647
Intra UXT Q9UBK9 NOTCH2NLA Homo sapiens Q7Z3S9
Y2H Array
31515488
Intra UXT Q9UBK9 NOTCH2NLA Homo sapiens Q7Z3S9
Y2H Array
25416956
Intra UXT Q9UBK9 KRT31 Homo sapiens Q15323
Y2H Prey Pooling
32296183
Intra UXT Q9UBK9 KRT31 Homo sapiens Q15323
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Retinitis Pigmentosa

RP

Rod-Cone Dystrophy

Autosomal Recessive Retinitis Pigmentosa

Non-Syndromic Retinitis Pigmentosa

Pericentral Pigmentary Retinopathy

Pigmentary Retinopathy

Tapetoretinal Degeneration

Rcd

Retinitis Pigmentosa Autosomal Recessive

ARRP

Retinitis Pigmentosa, Autosomal Recessive

Retinitis Pigmentosa 1
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS15591 UXT Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus UXT VGNC VGNC:36754
Felis catus UXT VGNC VGNC:66910
Rattus norvegicus UXT RGD RGD:1359326
Macaca mulatta UXT VGNC VGNC:103884
Canis familiaris UXT VGNC VGNC:48221
Mus musculus UXT MGD MGI:1277988
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z