2. Gene
  3. RPAP3 - RNA polymerase II associated protein 3 Gene

RPAP3 - RNA polymerase II associated protein 3 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：RNA 聚合酶 II 相关蛋白 3

种属: Homo sapiens

同用名: Tah1; hSpagh

基因 ID: 79657 | 基因类型: protein coding

关于 RPAP3

Cytogenetic location: 12q13.11 Genomic coordinates (GRCh38): 12:47,661,249-47,706,030 (from NCBI)

This gene has 7 transcripts (splice variants), 211 orthologues and 18 paralogues. Ubiquitous expression in lymph node (RPKM 11.2), appendix (RPKM 8.8) and 25 other tissues.

功能概要

该基因编码 RNA 聚合酶 II 相关蛋白。编码的蛋白质可能在转录调节中发挥作用，也可能调节细胞凋亡。已经描述了选择性剪接的转录物变体。[RefSeq 提供，2009 年 3 月]

This gene encodes an RNA polymerase II-associated protein. The encoded protein may function in transcriptional regulation and may also regulate Apoptosis. Alternatively spliced transcript variants have been described. [provided by RefSeq, Mar 2009]

RPAP3 基因产物(3)

mRNA Protein Name
NM_001146075.2 NP_001139547.1 RNA polymerase II-associated protein 3 isoform 2
NM_001146076.2 NP_001139548.1 RNA polymerase II-associated protein 3 isoform 3
NM_024604.3 NP_078880.2 RNA polymerase II-associated protein 3 isoform 1
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
18538670 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of R2TP complex IDA
IDA: 通过直接分析推断
26711270 GOA
part of R2TP complex IPI
IPI: 通过物理相互作用推断
29662061 GOA
part of RPAP3/R2TP/prefoldin-like complex IPI
IPI: 通过物理相互作用推断
31738558 GOA
part of protein folding chaperone complex IPI
IPI: 通过物理相互作用推断
29844425 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

RPAP3 蛋白结构

TPR_11

TPR_11: TPR repeat (131 - 197)

TPR_1

TPR_1: Tetratricopeptide repeat (202 - 234)

TPR_11

TPR_11: TPR repeat (281 - 346)

TPR_1

TPR_1: Tetratricopeptide repeat (351 - 383)

RPAP3_C

RPAP3_C: Potential Monad-binding region of RPAP3 (544 - 637)

  • 0
  • 200
  • 400
  • 600
  • 665 a.a.
蛋白主名 其他名称

RNA polymerase II-associated protein 3

RPAP3 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
RPAP3 Q9H6T3 DNAAF10 Homo sapiens Q96MX6
Anti Tag CoIP
33961781
种属内
RPAP3 Q9H6T3 DNAAF10 Homo sapiens Q96MX6
Anti Tag CoIP
25036637
种属内
RPAP3 Q9H6T3 DNAAF10 Homo sapiens Q96MX6
Pull Down
18538670
种属内
RPAP3 Q9H6T3 POLR3A Homo sapiens O14802
Anti Tag CoIP
33961781
种属内
RPAP3 Q9H6T3 POLR3A Homo sapiens O14802
Lumier
25036637
种属内
RPAP3 Q9H6T3 HSP90AA1 Homo sapiens P07900
ITC
24794838
种属内
RPAP3 Q9H6T3 HSP90AA1 Homo sapiens P07900
X-Ray Diffraction
24794838
种属内
RPAP3 Q9H6T3 HSP90AB1 Homo sapiens P08238
Pull Down
24794838
种属内
RPAP3 Q9H6T3 URI1 Homo sapiens O94763
Anti Tag CoIP
33961781
种属内
RPAP3 Q9H6T3 URI1 Homo sapiens O94763
Anti Tag CoIP
25036637
种属内
RPAP3 Q9H6T3 UXT Homo sapiens Q9UBK9
Anti Tag CoIP
33961781
种属内
RPAP3 Q9H6T3 UXT Homo sapiens Q9UBK9
Anti Tag CoIP
25036637
种属内
RPAP3 Q9H6T3 PFDN2 Homo sapiens Q9UHV9
Anti Tag CoIP
33961781
种属内
RPAP3 Q9H6T3 PFDN2 Homo sapiens Q9UHV9
Anti Tag CoIP
25036637
种属内
RPAP3 Q9H6T3 TERF1 Homo sapiens P54274
Pull Down
21044950
种属内
RPAP3 Q9H6T3 TERF1 Homo sapiens P54274
BiFC
21044950
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Primary Ciliary Dyskinesia

Immotile Cilia Syndrome

Kartagener Syndrome

Dextrocardia Bronchiectasis And Sinusitis

Pcd

Ciliary Motility Disorders

Ciliary Motility Disorder

Immotile Ciliary Syndrome

Ciliary Dyskinesia Primary

Ics

Polynesian Bronchiectasis

Dextrocardia-Bronchiectasis-Sinusitis Syndrome

Immotile Cilia Syndrome, Kartagener Type

Primary Ciliary Dyskinesia And Situs Inversus

Primary Ciliary Dyskinesia, Kartagener Type

Siewert Syndrome

Dyskinesia, Ciliary, Primary
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS12149 RPAP3 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus RPAP3 VGNC VGNC:34100
Felis catus RPAP3 VGNC VGNC:64730
Rattus norvegicus RPAP3 RGD RGD:1303036
Macaca mulatta RPAP3 VGNC VGNC:76834
Canis familiaris RPAP3 VGNC VGNC:45707
Mus musculus RPAP3 MGD MGI:1277218
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