2. Gene
  3. URI1 - URI1 prefoldin like chaperone Gene

URI1 - URI1 prefoldin like chaperone Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：URI1 预折叠样伴侣蛋白

种属: Homo sapiens

同用名: RMP; URI; NNX3; C19orf2; PPP1R19

基因 ID: 8725 | 基因类型: protein coding

关于 URI1

Cytogenetic location: 19q12 Genomic coordinates (GRCh38): 19:29,923,657-30,016,612 (from NCBI)

This gene has 13 transcripts (splice variants) and 213 orthologues. Ubiquitous expression in thyroid (RPKM 23.9), testis (RPKM 18.7) and 25 other tissues.

功能概要

该基因编码分子伴侣的 prefoldin 家族成员。编码的蛋白质作为支架蛋白发挥作用，并在泛素化和转录中发挥作用，部分是通过与 RNA 聚合酶 II 亚基 RPB5 的相互作用。该基因可能在包括卵巢癌和肝细胞癌在内的多种恶性肿瘤中发挥作用。已经观察到该基因编码多种亚型的可变剪接转录变体，并且该基因的假基因位于 22 号染色体的长臂上。[RefSeq 提供，2011 年 11 月]

This gene encodes member of the prefoldin family of molecular chaperones. The encoded protein functions as a scaffolding protein and plays roles in ubiquitination and transcription, in part though interactions with the RNA polymerase II subunit RPB5. This gene may play a role in multiple malignancies including ovarian Cancer and hepatocellular carcinoma. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 22. [provided by RefSeq, Nov 2011]

URI1 基因产物(2)

mRNA Protein Name
NM_001252641.2 NP_001239570.1 unconventional prefoldin RPB5 interactor 1 isoform c
NM_003796.3 NP_003787.2 unconventional prefoldin RPB5 interactor 1 isoform a
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables RNA polymerase II complex binding IDA
IDA: 通过直接分析推断
9819440 GOA
enables chromatin binding IDA
IDA: 通过直接分析推断
21730289 GOA
enables phosphoprotein binding IPI
IPI: 通过物理相互作用推断
20864032 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
12737519 GOA
enables transcription corepressor activity IDA
IDA: 通过直接分析推断
12737519 GOA
enables transcription corepressor activity IMP
IMP: 通过突变表型推断
9819440 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to growth factor stimulus IDA
IDA: 通过直接分析推断
17936702 GOA
involved in cellular response to steroid hormone stimulus IDA
IDA: 通过直接分析推断
21730289 GOA
involved in negative regulation of intrinsic apoptotic signaling pathway IMP
IMP: 通过突变表型推断
17936702 GOA
involved in negative regulation of phosphatase activity IMP
IMP: 通过突变表型推断
17936702 GOA
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
12737519 GOA
involved in regulation of cell growth IDA
IDA: 通过直接分析推断
21730289 GOA
involved in regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
9819440 GOA
involved in response to virus IMP
IMP: 通过突变表型推断
9819440 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of RPAP3/R2TP/prefoldin-like complex IPI
IPI: 通过物理相互作用推断
31738558 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
15367675 GOA
located in nucleus IDA
IDA: 通过直接分析推断
15367675 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

URI1 蛋白结构

Prefoldin

Prefoldin: Prefoldin subunit (1 - 71)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 459 a.a.
蛋白主名 其他名称

unconventional prefoldin RPB5 interactor 1

RNA polymerase II subunit 5-mediating protein

URI1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
URI1 O94763 GTF2F2 Homo sapiens P13984
Pull Down
12737519
种属间
URI1 O94763 Esr1 Mus musculus P19785
Anti Bait CoIP
25453901
种属内
URI1 O94763 PPP1CC Homo sapiens P36873
Anti Bait CoIP
27505673
种属内
URI1 O94763 PPP1CC Homo sapiens P36873
Anti Bait CoIP
21397856
种属内
URI1 O94763 RPAP3 Homo sapiens Q9H6T3
Lumier
25036637
种属内
URI1 O94763 PFDN2 Homo sapiens Q9UHV9
Anti Bait CoIP
15923622
种属内
URI1 O94763 POLR2E Homo sapiens P19388
Anti Bait CoIP
15923622
种属内
URI1 O94763 GTF2F1 Homo sapiens P35269
Pull Down
12737519
种属内
URI1 O94763 OGT Homo sapiens O15294
Pull Down
27505673
种属内
URI1 O94763 OGT Homo sapiens O15294
Anti Bait CoIP
27505673
种属间
URI1 O94763 Ahr Mus musculus P30561
Anti Bait CoIP
25453901
种属间: 跨种属相互作用 种属内: 同种属相互作用

URI1 抗体

目录号 产品名 应用 反应物种
HY-P81462 URI1 Antibody (YA1207) IHC-P Human

关联疾病

疾病名称 别名
Ovarian Cancer

Ovarian Carcinoma

Ovarian Neoplasm

Malignant Tumour Of Ovary

Cancer Of The Ovary

Epithelial Ovarian Cancer

Neoplasm Of Ovary

Ovarian Neoplasms

Ovarian Cancers

Malignant Neoplasm Of Ovary

Primary Malignant Neoplasm Of Ovary

Ovarian Cancer, Somatic

Malignant Ovarian Tumor

Ovary Neoplasm

Primary Ovarian Cancer

Tumor Of The Ovary

Malignant Neoplasm Of The Ovary

Malignant Tumor Of The Ovary

Ovarian Malignant Tumor

OC

Ovarian Carcinomas

Cancer, Ovarian

Cancer Of Ovary

Ovary Cancer

Ca Ovary
Hypermobility Of Coccyx

Coccygeal Hypermobility Syndrome

Hypermobility Of The Coccyx
Klippel-Feil Syndrome 3
Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer
Neurodegeneration With Brain Iron Accumulation 4

NBIA4

Mpan

Mitochondrial Protein-Associated Neurodegeneration

Nbia Due To C19orf12 Mutation

Neurodegeneration With Brain Iron Accumulation Due To C19orf12 Mutation

Neurodegeneration With Brain Iron Accumulation Type 4

Mitochondrial Membrane Protein Associated Neurodegeneration

Neurodegeneration, With Brain Iron Accumulation, Type 4
Hepatocellular Carcinoma

Liver Cancer

Primary Liver Cancer

HCC

Hepatoma

Malignant Neoplasm Of Liver

Liver Neoplasms

Cancer, Hepatocellular

Liver Cell Carcinoma

Lcc

Hepatoblastoma, Somatic

Hepatic Cancer

Primary Malignant Neoplasm Of Liver

Rare Tumor Of Liver And Intrahepatic Biliary Tract

Hepatocellular Carcinoma, Somatic

Hepatocellular Carcinoma, Childhood Type, Somatic

Hepatocellular Cancer, Somatic

Ca Liver - Primary

Hepatic Neoplasm

Malignant Hepato-Biliary Neoplasm

Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

Malignant Neoplasm Of Liver, Primary

Malignant Tumor Of Liver

Neoplasm Of Liver

Non-Resectable Primary Hepatic Malignant Neoplasm

Resectable Malignant Neoplasm Of Liver

Resectable Malignant Neoplasm Of The Liver

Primary Liver Carcinoma

Primary Malignant Liver Neoplasm

Primary Cancer Of Liver

Primary Tumor Of The Liver

Rare Tumor Of Liver And Ibt

Hepatocellular Cancer

Neoplasm Of The Liver

Carcinoma, Hepatocellular

Hepatomas

Liver Neoplasm

Liver Carcinoma

Liver And Intrahepatic Biliary Tract Carcinoma

Malignant Hepatobiliary Neoplasm

Adult Primary Hepatocellular Carcinoma

Hepatoblastoma

Carcinoma Of Liver

Malignant Liver Tumour

Malignant Hepatic Tumour
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Approval
生物活性分子 (2)
目录号 产品名 作用方式
纯度 是否罕见病
HY-A0161A Chlophedianol hydrochloride 99.62% 否
HY-A0161 Chlophedianol / 否
Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-A0161S Chlophedianol-13C6 / 否
HY-RS15507 URI1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus URI1 VGNC VGNC:36698
Mus musculus URI1 MGD MGI:1342294
Macaca mulatta URI1 VGNC VGNC:78918
Canis familiaris URI1 VGNC VGNC:48166
Felis catus URI1 VGNC VGNC:66853
Rattus norvegicus URI1 RGD RGD:1310358
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