POLR2E - RNA polymerase II, I and III subunit E Gene

中文名称：RNA 聚合酶 II、I 和 III 亚基 E

种属: Homo sapiens

同用名: RPB5; XAP4; RPABC1; hRPB25; hsRPB5

关于 POLR2E

功能概要

该基因编码 RNA 聚合酶 II 的第五大亚基，该聚合酶负责在真核生物中合成信使 RNA。该亚基由其他两种 DNA 指导的 RNA 聚合酶共享，并且以超过其他聚合酶亚基两倍的摩尔浓度存在。该亚基与肝炎病毒反式激活蛋白之间的相互作用已得到证实，表明转录激活因子与聚合酶之间的相互作用可通过该亚基发生。一个假基因位于 11 号染色体上。已发现该基因的三个转录本变体编码两个不同的亚型。[RefSeq 提供，2015 年 10 月]

This gene encodes the fifth largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This subunit is shared by the Other two DNA-directed RNA polymerases and is present in two-fold molar excess over the Other polymerase subunits. An interaction between this subunit and a hepatitis virus transactivating protein has been demonstrated, suggesting that interaction between transcriptional activators and the polymerase can occur through this subunit. A pseudogene is located on chromosome 11. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]