1. Gene
  2. IP6K3 - inositol hexakisphosphate kinase 3 Gene

IP6K3 - inositol hexakisphosphate kinase 3 Gene

中文名称:肌醇六磷酸激酶 3

种属: Homo sapiens

同用名: IHPK3; INSP6K3

基因 ID: 117283 | 基因类型: protein coding

关于 IP6K3

Cytogenetic location: 6p21.31 Genomic coordinates (GRCh38): 6:33,721,662-33,762,145 (from NCBI)

This gene has 3 transcripts (splice variants), 138 orthologues and 6 paralogues. Broad expression in thyroid (RPKM 4.4), heart (RPKM 3.1) and 14 other tissues.

功能概要

该基因编码属于肌醇磷酸激酶 (IPK) 家族的蛋白质。这种蛋白质可能负责将肌醇六磷酸 (InsP6) 转化为二磷酸肌醇五磷酸 (InsP7/PP-InsP5) 。它还可以将 1,3,4,5,6-五磷酸 (InsP5) 转化为 PP-InsP4。可变剪接导致编码相同蛋白质的多个转录变体。[RefSeq 提供,2008 年 12 月]

This gene encodes a protein that belongs to the inositol phosphokinase (IPK) family. This protein is likely responsible for the conversion of inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). It may also convert 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4. Alternative splicing results in multiple transcript variants encoding the same protein.[provided by RefSeq, Dec 2008]

IP6K3 基因产物(2)

mRNA Protein Name
NM_001142883.2 NP_001136355.1 inositol hexakisphosphate kinase 3
NM_054111.5 NP_473452.2 inositol hexakisphosphate kinase 3
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables inositol hexakisphosphate 6-kinase activity IDA
IDA: 通过直接分析推断
11502751 GOA
enables inositol hexakisphosphate kinase activity IDA
IDA: 通过直接分析推断
11502751 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within inositol phosphate biosynthetic process IDA
IDA: 通过直接分析推断
11502751 GOA
involved in phosphatidylinositol metabolic process IDA
IDA: 通过直接分析推断
11502751 GOA
involved in protein phosphorylation IDA
IDA: 通过直接分析推断
11502751 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
11502751 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

IP6K3 蛋白结构

IPK

IPK: Inositol polyphosphate kinase (198 - 404)

  • 0
  • 100
  • 200
  • 300
  • 410 a.a.
蛋白主名 其他名称

inositol hexakisphosphate kinase 3

ATP:1D-myo-inositol-hexakisphosphate phosphotransferase

IP6K3 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra IP6K3 Q96PC2 KRTAP10-8 Homo sapiens P60410
Y2H Prey Pooling
32296183
Intra IP6K3 Q96PC2 KRTAP10-8 Homo sapiens P60410
Y2H Array
32296183
Intra IP6K3 Q96PC2 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
Intra IP6K3 Q96PC2 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
Intra IP6K3 Q96PC2 NOTO Homo sapiens A8MTQ0
Y2H Array
32296183
Intra IP6K3 Q96PC2 NOTO Homo sapiens A8MTQ0
Y2H Prey Pooling
32296183
Intra IP6K3 Q96PC2 TRAF2 Homo sapiens Q12933
Y2H Array
32296183
Intra IP6K3 Q96PC2 TRAF2 Homo sapiens Q12933
Y2H Prey Pooling
32296183
Intra IP6K3 Q96PC2 MED4 Homo sapiens Q9NPJ6
Y2H Array
32296183
Intra IP6K3 Q96PC2 MED4 Homo sapiens Q9NPJ6
Y2H Prey Pooling
32296183
Intra IP6K3 Q96PC2 MED4 Homo sapiens Q9NPJ6
Validated Y2H
32296183
Intra IP6K3 Q96PC2 POLR2E Homo sapiens P19388
Y2H Prey Pooling
32296183
Intra IP6K3 Q96PC2 POLR2E Homo sapiens P19388
Y2H Array
32296183
Intra IP6K3 Q96PC2 ZRANB1 Homo sapiens Q9UGI0
Validated Y2H
32296183
Intra IP6K3 Q96PC2 ZRANB1 Homo sapiens Q9UGI0
Y2H Prey Pooling
32296183
Intra IP6K3 Q96PC2 ZRANB1 Homo sapiens Q9UGI0
Y2H Array
32296183
Intra IP6K3 Q96PC2 ZNF655 Homo sapiens Q8N720
Y2H Prey Pooling
32296183
Intra IP6K3 Q96PC2 ZNF655 Homo sapiens Q8N720
Y2H Array
32296183
Intra IP6K3 Q96PC2 TRIM27 Homo sapiens P14373
Y2H Array
32296183
Intra IP6K3 Q96PC2 TRIM27 Homo sapiens P14373
Y2H Prey Pooling
32296183
Intra IP6K3 Q96PC2 NIF3L1 Homo sapiens Q9GZT8
Y2H Prey Pooling
32296183
Intra IP6K3 Q96PC2 NIF3L1 Homo sapiens Q9GZT8
Validated Y2H
32296183
Intra IP6K3 Q96PC2 NIF3L1 Homo sapiens Q9GZT8
Y2H Array
32296183
Intra IP6K3 Q96PC2 TRIP6 Homo sapiens Q15654
Y2H Prey Pooling
32296183
Intra IP6K3 Q96PC2 TRIP6 Homo sapiens Q15654
Y2H Array
32296183
Intra IP6K3 Q96PC2 FHL5 Homo sapiens Q5TD97
Y2H Prey Pooling
32296183
Intra IP6K3 Q96PC2 FHL5 Homo sapiens Q5TD97
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

直系同源

种属 基因名 来源 基因 ID
Bos taurus IP6K3 VGNC VGNC:107290
Mus musculus IP6K3 MGD MGI:3045325
Felis catus IP6K3 VGNC VGNC:102444
Canis familiaris IP6K3 VGNC VGNC:42063
Macaca mulatta IP6K3 VGNC VGNC:81083
Rattus norvegicus IP6K3 RGD RGD:1584104