OGT - O-linked N-acetylglucosamine (GlcNAc) transferase Gene

中文名称：O-连接的 N-乙酰葡糖胺 (GlcNAc) 转移酶

种属: Homo sapiens

同用名: OGT1; HRNT1; MRX106; XLID106; HINCUT-1; O-GLCNAC

基因 ID: 8473 | 基因类型: protein coding

关于 OGT

Cytogenetic location: Xq13.1 Genomic coordinates (GRCh38): X:71,533,104-71,575,892 (from NCBI)

This gene has 21 transcripts (splice variants), 263 orthologues, 14 paralogues and is associated with 3 phenotypes. Ubiquitous expression in lymph node (RPKM 56.6), spleen (RPKM 53.1) and 25 other tissues.

功能概要

该基因编码一种糖基转移酶，该酶催化在 O-糖苷键中将单个 N-乙酰葡糖胺添加到丝氨酸或苏氨酸残基上。由于磷酸化和糖基化都竞争相似的丝氨酸或苏氨酸残基，因此这两个过程可能会竞争位点，或者它们可能会通过空间或静电效应改变附近位点的底物特异性。该蛋白质包含最佳识别底物所需的多个四肽重复序列。已发现该基因编码不同亚型的可变剪接转录物变体。[RefSeq 提供，2009 年 10 月]

This gene encodes a Glycosyltransferase that catalyzes the addition of a single N-acetylglucosamine in O-glycosidic linkage to serine or threonine residues. Since both phosphorylation and glycosylation compete for similar serine or threonine residues, the two processes may compete for sites, or they may alter the substrate specificity of nearby sites by steric or electrostatic effects. The protein contains multiple tetratricopeptide repeats that are required for optimal recognition of substrates. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Oct 2009]

OGT 基因产物(2)

mRNA	Protein	Name
NM_181672.3	NP_858058.1	UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit isoform 1
NM_181673.3	NP_858059.1	UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit isoform 2

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables phosphatidylinositol-3,4,5-trisphosphate binding	IDA IDA: 通过直接分析推断	18288188	GOA
enables protein O-acetylglucosaminyltransferase activity	EXP EXP: 通过实验结果推断	30770249	GOA
enables protein O-acetylglucosaminyltransferase activity	IDA IDA: 通过直接分析推断	21285374	GOA
enables protein O-acetylglucosaminyltransferase activity	IMP IMP: 通过突变表型推断	23777819	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	12150998	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in apoptotic process	IDA IDA: 通过直接分析推断	20824293	GOA
involved in cellular response to glucose stimulus	IDA IDA: 通过直接分析推断	37541260	GOA
involved in negative regulation of non-canonical inflammasome complex assembly	IDA IDA: 通过直接分析推断	37962578	GOA
involved in negative regulation of proteasomal ubiquitin-dependent protein catabolic process	IMP IMP: 通过突变表型推断	26678539	GOA
involved in negative regulation of protein ubiquitination	IMP IMP: 通过突变表型推断	26678539	GOA
involved in positive regulation of TORC1 signaling	IDA IDA: 通过直接分析推断	37541260	GOA
involved in positive regulation of proteolysis	IDA IDA: 通过直接分析推断	21285374	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	23222540	GOA
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: 通过突变表型推断	23352454	GOA
involved in positive regulation of translation	IDA IDA: 通过直接分析推断	34074792	GOA
involved in protein O-linked glycosylation	IDA IDA: 通过直接分析推断	21240259	GOA
involved in protein O-linked glycosylation	IMP IMP: 通过突变表型推断	23353889	GOA
involved in protein processing	IMP IMP: 通过突变表型推断	28584052	GOA
involved in regulation of Rac protein signal transduction	IDA IDA: 通过直接分析推断	18288188	GOA
involved in regulation of glycolytic process	IDA IDA: 通过直接分析推断	22923583	GOA
involved in regulation of insulin receptor signaling pathway	IDA IDA: 通过直接分析推断	18288188	GOA
involved in regulation of transcription by RNA polymerase II	IMP IMP: 通过突变表型推断	26678539	GOA
involved in response to insulin	IDA IDA: 通过直接分析推断	18288188	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of NSL complex	IDA IDA: 通过直接分析推断	20018852	GOA
located in cytosol	IDA IDA: 通过直接分析推断	21285374	GOA
part of histone acetyltransferase complex	IDA IDA: 通过直接分析推断	20018852	GOA
located in nucleus	IDA IDA: 通过直接分析推断	21285374	GOA
located in plasma membrane	IDA IDA: 通过直接分析推断	18288188	GOA
part of protein N-acetylglucosaminyltransferase complex	IDA IDA: 通过直接分析推断	21240259	GOA
part of protein-containing complex	IDA IDA: 通过直接分析推断	26678539	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

OGT 蛋白结构

TPR_11

TPR_1

TPR_11

Glyco_transf_41

0
200
400
600
800
1046 a.a.

蛋白主名

其他名称

UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

O-GlcNAc transferase p110 subunit

OGT 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	OGT	O15294	TET2	Homo sapiens	E7EQS8	Y2H Prey Pooling	25416956
种属内	OGT	O15294	TET2	Homo sapiens	E7EQS8	Validated Y2H	25416956
种属内	OGT	O15294	TRAK1	Homo sapiens	Q9UPV9	TAP	27705803
种属内	OGT	O15294	PHC3	Homo sapiens	Q8NDX5	Y2H Prey Pooling	25416956
种属内	OGT	O15294	PHC3	Homo sapiens	Q8NDX5	Y2H Array	25416956
种属内	OGT	O15294	TET2	Homo sapiens	Q6N021-1	Pull Down	23222540
种属内	OGT	O15294	TET3	Homo sapiens	O43151	Pull Down	23353889
种属内	OGT	O15294	TET3	Homo sapiens	O43151	Pull Down	23222540
种属内	OGT	O15294	TET2	Homo sapiens	Q6N021	Anti Bait CoIP	23353889
种属内	OGT	O15294	TET2	Homo sapiens	Q6N021	Pull Down	23353889
种属内	OGT	O15294	PPP1CC	Homo sapiens	P36873	Anti Bait CoIP	27505673
种属内	OGT	O15294	URI1	Homo sapiens	O94763	Anti Bait CoIP	27505673
种属内	OGT	O15294	URI1	Homo sapiens	O94763	Pull Down	27505673
种属内	OGT	O15294	URI1	Homo sapiens	O94763	Enzymatic Study	27505673
种属内	OGT	O15294	URI1	Homo sapiens	O94763	Anti Tag CoIP	27505673
种属内	OGT	O15294	TAB1	Homo sapiens	Q15750	Enzymatic Study	27505673
种属间	OGT	O15294	Hoxa1	Mus musculus	P09022	BiFC	23088713
种属间	OGT	O15294	Hoxa1	Mus musculus	P09022	Y2H	23088713
种属内	OGT	O15294	HCFC1	Homo sapiens	P51610	TAP	27705803
种属内	OGT	O15294	HCFC1	Homo sapiens	P51610	Protease Assay	21295698
种属内	OGT	O15294	SNAP29	Homo sapiens	O95721	Pull Down	25419848
种属内	OGT	O15294	SNAP29	Homo sapiens	O95721	Anti Tag CoIP	25419848
种属内	OGT	O15294	NFATC1	Homo sapiens	O95644	Anti Bait CoIP	17882263
种属内	OGT	O15294	PSG1	Homo sapiens	P11464	Y2H Prey Pooling	25416956
种属内	OGT	O15294	PSG1	Homo sapiens	P11464	Validated Y2H	25416956
种属内	OGT	O15294	RELA	Homo sapiens	Q04206	Anti Bait CoIP	17882263
种属内	OGT	O15294	NUP62CL	Homo sapiens	Q9H1M0	Y2H Prey Pooling	25416956
种属内	OGT	O15294	NUP62CL	Homo sapiens	Q9H1M0	Y2H Pooling	16189514
种属间	OGT	O15294	Tet3	Mus musculus	Q8BG87	Pull Down	23353889
种属间	OGT	O15294	Tet3	Mus musculus	Q8BG87	Anti Tag CoIP	23353889
种属间	OGT	O15294	Ppp1cc	Rattus norvegicus	P63088	Pull Down	27505673

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Intellectual Developmental Disorder, X-Linked 106

XLID106	Mrx106
Mental Retardation, X-Linked 106	Mental Retardation, X-Linked, Type 106

Myoepithelioma

Benign Myoepithelioma	Myoepithelial Adenoma
Myoepithelial Neoplasm	Malignant Myoepithelioma

Bainbridge-Ropers Syndrome

BRPS	Severe Feeding Difficulties-Failure To Thrive-Microcephaly Due To Asxl3 Deficiency Syndrome
Asxl3-Related Disorder

Adams-Oliver Syndrome

Adams Oliver Syndrome	Aos
Congenital Scalp Defects With Distal Limb Reduction Anomalies	Aplasia Cutis Congenita With Terminal Transverse Limb Defects
Congenital Scalp Defects With Distal Limb Anomalies	Limb, Scalp And Skull Defects
Limb Scalp And Skull Defects	Absence Defect Of Limbs, Scalp, And Skull

Type 2 Diabetes Mellitus

Insulin Resistance	NIDDM
Type 2 Diabetes	Diabetes Mellitus, Non-Insulin-Dependent
T2D	Noninsulin-Dependent Diabetes Mellitus
Diabetes Mellitus, Type Ii	Maturity-Onset Diabetes
Insulin Resistance, Severe, Digenic	Diabetes Mellitus, Type 2
Diabetes Mellitus, Noninsulin-Dependent	Diabetes Mellitus, Noninsulin-Dependent, Association With
Diabetes Mellitus, Noninsulin-Dependent, Late Onset	Hypertension, Insulin Resistance-Related, Susceptibility To
Insulin Resistance, Susceptibility To	Non-Insulin-Dependent Diabetes Mellitus
Type Ii Diabetes Mellitus	Adult-Onset Diabetes Mellitus
Maturity-Onset Diabetes Mellitus	Diabetes Mellitus Type 2
Type Ii Diabetes	Type 2 Diabetes Mellitus, Susceptibility To
Diabetes, Type 2	Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To
Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To	Diabetes Mellitus, Type 2, Susceptibility To
Diabetes Mellitus, Noninsulin-Dependent, 2	Diabetes Mellitus, Type Ii, Susceptibility To
Hypertension, Insulin Resistance-Related	Adult-Onset Diabetes
Aodm	Diabetes Mellitus, Adult-Onset
Diabetes Mellitus Type Ii	Diabetes Mellitus Type 2, Susceptibility To
Diabetes, Type Ii, Susceptibility To	Diabetes Type 2
Diabetes Mellitus	Adult Onset Diabetes
Maturity Onset Diabetes	Nonketotic Diabetes
Non-Insulin Dependent Diabetes Mellitus	T2dm - [Type 2 Diabetes Mellitus]
Niddm - [Non Insulin Dependent Diabetes Mellitus]	Dm2
Dm Type Ii	Diabetic Type 2
Insulin Requiring Type 2 Diabetes	Noninsulin Dependent Diabetes
Non-Insulin-Dependent Diabetes Mellitus Without Complications	Diabetes Due To Insulin Secretory Defect
Diabetes Mellitus Due To Insulin Secretory Defect	Non-Insulin-Dependent Diabetes Of The Young
Senile Diabetes	Nonketotic Hyperglycaemia
Stable Diabetes

Alzheimer Disease, Familial, 1

Alzheimer Disease	Alzheimer'S Disease
Presenile And Senile Dementia	AD1
Alzheimer Disease, Susceptibility To	Alzheimer Disease, Late-Onset, Susceptibility To
Alzheimer Disease 1, Familial	AD
Familial Alzheimer Disease	Alzheimer Disease, Late-Onset
Alzheimers Dementia	Alzheimer Dementia
Alzheimer Sclerosis	Alzheimer Syndrome
Alzheimer-Type Dementia	Dat
Primary Senile Degenerative Dementia	Sdat
Alzheimer Disease 1	Autosomal Dominant Alzheimer Disease
Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy	Late Onset Alzheimer Disease
Alzheimers Disease	Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy
Late-Onset Alzheimers Disease	Alzheimer'S Disease Pathway Kegg
Dementia Due To Alzheimer'S Disease	Alzheimer Disease Type 1
Alzheimers

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-119738	OSMI-1	Inhibitor	99.90%	否
HY-114361	OSMI-4	Inhibitor	99.55%	否
HY-112174	UDP-GlcNAc disodium		≥99.0%	否
HY-136282	OGT-IN-2	Inhibitor	99.82%	否
HY-145934A	UDP-GlcNAz disodium		98.93%	否
HY-139793	UDP-glucosamine disodium		99.43%	否
HY-135784	OSMI-2	Inhibitor	98.73%	否
HY-148113	PG 34		≥98.0%	否
HY-119738A	(Rac)-OSMI-1	Inhibitor	96.51%	否
HY-101548	OGT-IN-1	Inhibitor	98.14%	否
HY-125278	OGT-IN-4	Inhibitor	/	否
HY-135785	OSMI-3	Inhibitor	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	OGT	MGD	MGI:1339639
Rattus norvegicus	OGT	RGD	RGD:62060
Others	OGT	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

OGT - O-linked N-acetylglucosamine (GlcNAc) transferase Gene

关于 OGT

功能概要

OGT 基因产物(2)

OGT 蛋白结构

OGT 蛋白互作信息

关联疾病

直系同源

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OGT - O-linked N-acetylglucosamine (GlcNAc) transferase Gene

关于 OGT

功能概要

OGT 基因产物(2)

OGT 蛋白结构

OGT 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

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B

C

F

G

H

J

L

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Q

S

T

X

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