TAB1 - TGF-beta activated kinase 1 (MAP3K7) binding protein 1 Gene

中文名称：TGF-β 活化激酶 1 (MAP3K7) 结合蛋白 1

种属: Homo sapiens

同用名: 3'-Tab1; MAP3K7IP1

基因 ID: 10454 | 基因类型: protein coding

关于 TAB1

Cytogenetic location: 22q13.1 Genomic coordinates (GRCh38): 22:39,399,780-39,437,132 (from NCBI)

This gene has 7 transcripts (splice variants), 201 orthologues and 16 paralogues. Ubiquitous expression in ovary (RPKM 7.9), brain (RPKM 7.3) and 25 other tissues.

功能概要

由该基因编码的蛋白质被鉴定为 MAP 激酶激酶激酶 MAP3K7/TAK1 的调节因子，已知其可介导各种细胞内信号通路，例如由 TGF β、白细胞介素 1 和 WNT-1 诱导的信号通路。该蛋白质相互作用并因此激活 TAK1 激酶。已经表明，该蛋白的 C 端部分足以结合和激活 TAK1，而 N 端的一部分充当 TGF β 的显性失活抑制剂，表明该蛋白可能作为介体发挥作用 TGF β 受体和 TAK1 之间。这种蛋白质还可以与丝裂原活化蛋白激酶 14 (MAPK14/p38alpha) 相互作用并激活它，因此代表了除了 MAPKK 通路之外的另一种激活通路，这有助于 MAPK14 对各种刺激的生物学反应。已经报道了编码不同亚型的可变剪接转录物变体。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

TAB1 基因产物(2)

mRNA	Protein	Name
NM_006116.3	NP_006107.1	TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform alpha
NM_153497.3	NP_705717.1	TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform beta

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables molecular adaptor activity	IDA IDA: 通过直接分析推断	16260783	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	10094049	GOA
enables protein serine/threonine kinase activator activity	IDA IDA: 通过直接分析推断	37832545	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in non-canonical NF-kappaB signal transduction	IDA IDA: 通过直接分析推断	16260783	GOA
involved in positive regulation of cGAS/STING signaling pathway	IDA IDA: 通过直接分析推断	37832545	GOA
involved in positive regulation of protein serine/threonine kinase activity	IDA IDA: 通过直接分析推断	11865055	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
is active in cytoplasm	IDA IDA: 通过直接分析推断	34017102	GOA
is active in endoplasmic reticulum	IDA IDA: 通过直接分析推断	37832545	GOA
is active in endoplasmic reticulum membrane	IDA IDA: 通过直接分析推断	37832545	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TAB1 蛋白结构

PP2C

0
100
200
300
400
504 a.a.

蛋白主名

其他名称

TGF-beta-activated kinase 1 and MAP3K7-binding protein 1

TAK1-binding protein 1

TAB1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	TAB1	Q15750	YWHAE	Homo sapiens	P62258	Crosslink	36931259
Intra	TAB1	Q15750	MAP3K7	Homo sapiens	O43318	Anti Tag CoIP	33961781
Intra	TAB1	Q15750	MAP3K7	Homo sapiens	O43318	Anti Tag CoIP	27880917
Intra	TAB1	Q15750	MAP3K7	Homo sapiens	O43318	Anti Tag CoIP	16845370
Intra	TAB1	Q15750	MAP3K7	Homo sapiens	O43318-2	TAP	14743216
Intra	TAB1	Q15750	TAB2	Homo sapiens	Q9NYJ8	Anti Bait CoIP	16845370
Intra	TAB1	Q15750	TAB2	Homo sapiens	Q9NYJ8	Anti Tag CoIP	27880917
Intra	TAB1	Q15750	TAB2	Homo sapiens	Q9NYJ8	Anti Tag CoIP	33961781
Intra	TAB1	Q15750	TAB2	Homo sapiens	Q9NYJ8	Anti Tag CoIP	25260751
Intra	TAB1	Q15750	TAB2	Homo sapiens	Q9NYJ8	TAP	14743216
Intra	TAB1	Q15750	XIAP	Homo sapiens	P98170	BFG-2H	27107012
Intra	TAB1	Q15750	XIAP	Homo sapiens	P98170	Validated Y2H	27107012
Intra	TAB1	Q15750	XIAP	Homo sapiens	P98170	Anti Tag CoIP	33961781

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Ectodermal Dysplasia 10a, Hypohidrotic/Hair/Nail Type, Autosomal Dominant

ECTD10A	Hed
Ectodermal Dysplasia 10a	Ectodermal Dysplasia Hypohidrotic Autosomal Dominant
Autosomal Dominant Hypohidrotic Ectodermal Dysplasia	Ectodermal Dysplasia, Hypohidrotic, Autosomal Dominant
Hypohidrotic Ectodermal Dysplasia Autosomal Dominant	Ad-Hed
Autosomal Dominant Anhidrotic Ectodermal Dysplasia	Ectodermal Dysplasia 3
Ed3	Eda3
Ectodermal Dysplasia, Anhidrotic, Autosomal Dominant	Dysplasia, Ectodermal, Type 10a, Hypohidrotic/Hair/Nail, Autosomal Dominant
Dysplasia, Ectodermal, Type 3

Frontometaphyseal Dysplasia

Fmd	Dysplasia, Frontometaphyseal

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Noonan Syndrome 1

Noonan Syndrome	NS1
Male Turner Syndrome	Female Pseudo-Turner Syndrome
Turner Phenotype With Normal Karyotype	Noonan Syndrome With Pigmented Villonodular Synovitis
Turner'S Phenotype, Karyotype Normal	Familial Turner Syndrome
Noonan'S Syndrome	Noonan-Ehmke Syndrome
Ns	Pseudo-Ullrich-Turner Syndrome
Turner Syndrome In Female With X Chromosome	Turner-Like Syndrome
Ullrich-Noonan Syndrome	Noonan-Like/Multiple Giant Cell Lesion Syndrome
Noonan Syndrome-Like Disorder With Multiple Giant Cell Lesions	Pterygium Colli Syndrome
Noonan Syndrome, Type 1	Turner Syndrome, Male

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-114454	INH14	Inhibitor	≥98.0%	否
HY-N2435	[8]-Shogaol		99.93%	否
HY-RS14133	TAB1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-167704	NF023		/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	TAB1	VGNC	VGNC:58447
Mus musculus	TAB1	MGD	MGI:1913763
Canis familiaris	TAB1	VGNC	VGNC:54550
Rattus norvegicus	TAB1	RGD	RGD:1306216
Macaca mulatta	TAB1	VGNC	VGNC:84536
Others	TAB1	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

TAB1 - TGF-beta activated kinase 1 (MAP3K7) binding protein 1 Gene

关于 TAB1

功能概要

TAB1 基因产物(2)

TAB1 蛋白结构

TAB1 蛋白互作信息

关联疾病

直系同源

热门区域

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TAB1 - TGF-beta activated kinase 1 (MAP3K7) binding protein 1 Gene

关于 TAB1

功能概要

TAB1 基因产物(2)

TAB1 蛋白结构

TAB1 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

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B

C

F

G

H

J

L

N

Q

S

T

X

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