2. Gene
  3. DYNLT1 - dynein light chain Tctex-type 1 Gene

DYNLT1 - dynein light chain Tctex-type 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：动力蛋白轻链 Tctex-type 1

种属: Homo sapiens

同用名: CW-1; TCTEL1; TCTEX1; tctex-1

基因 ID: 6993 | 基因类型: protein coding

关于 DYNLT1

Cytogenetic location: 6q25.3 Genomic coordinates (GRCh38): 6:158,636,474-158,644,743 (from NCBI)

This gene has 3 transcripts (splice variants), 219 orthologues and 5 paralogues. Ubiquitous expression in testis (RPKM 62.3), colon (RPKM 58.0) and 25 other tissues.

功能概要

该基因编码运动复合体的一个成分，细胞质动力蛋白，它沿着细胞中的微管运输细胞货物。编码的蛋白质调节初级纤毛的长度，初级纤毛是细胞表面的感觉细胞器。由该基因编码的蛋白质与病毒蛋白相互作用，如人乳头瘤病毒的次要衣壳蛋白 L2，并且是动力蛋白介导的病毒核酸向宿主细胞核的递送所必需的。这种蛋白质与致癌核孔蛋白相互作用，破坏基因调控并引起白血病转化。该基因的假基因存在于 4 号和 17 号染色体上。可变剪接导致编码不同亚型的多个转录变体。[RefSeq 提供，2014 年 4 月]

This gene encodes a component of the motor complex, cytoplasmic dynein, which transports cellular cargo along microtubules in the cell. The encoded protein regulates the length of primary cilia which are sensory organelles found on the surface of cells. The protein encoded by this gene interacts with Viral Proteins, like the minor capsid protein L2 of human papillomavirus, and is required for dynein-mediated delivery of the viral nucleic acid to the host nucleus. This protein interacts with oncogenic nucleoporins to disrupt gene regulation and cause leukemic transformation. Pseudogenes of this gene are present on chromosomes 4 and 17. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2014]

DYNLT1 基因产物(3)

mRNA Protein Name
NM_001291602.2 NP_001278531.1 dynein light chain Tctex-type 1 isoform 2
NM_001291603.2 NP_001278532.1 dynein light chain Tctex-type 1 isoform 3
NM_006519.4 NP_006510.1 dynein light chain Tctex-type 1 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables identical protein binding IPI
IPI: 通过物理相互作用推断
17965411 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
10644691 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in intracellular transport of viral protein in host cell IMP
IMP: 通过突变表型推断
18647839 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of cytoplasmic dynein complex IDA
IDA: 通过直接分析推断
25205765 GOA
located in cytoplasmic microtubule IDA
IDA: 通过直接分析推断
21262767 GOA
part of dynein complex IPI
IPI: 通过物理相互作用推断
24986880 GOA
located in secretory vesicle IDA
IDA: 通过直接分析推断
21262767 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

DYNLT1 蛋白结构

Tctex-1

Tctex-1: Tctex-1 family (15 - 112)

  • 0
  • 100
  • 113 a.a.
蛋白主名 其他名称

dynein light chain Tctex-type 1

T-complex testis-specific protein 1 homolog

DYNLT1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
DYNLT1 P63172 PELO Homo sapiens Q9BRX2
Validated Y2H
32296183
种属内
DYNLT1 P63172 HSPB9 Homo sapiens Q9BQS6
Y2H
15503857
种属内
DYNLT1 P63172 HSPB9 Homo sapiens Q9BQS6
Anti Bait CoIP
15503857
种属内
DYNLT1 P63172 TCEANC Homo sapiens Q8N8B7-2
Validated Y2H
32296183
种属内
DYNLT1 P63172 ARID4B Homo sapiens Q4LE39-3
Validated Y2H
32296183
种属内
DYNLT1 P63172 OLFM3 Homo sapiens Q96PB7-3
Validated Y2H
32296183
种属内
DYNLT1 P63172 ACOX2 Homo sapiens Q99424
Validated Y2H
32296183
种属内
DYNLT1 P63172 DYNC1I2 Homo sapiens Q13409-3
Validated Y2H
32296183
种属内
DYNLT1 P63172 PITX2 Homo sapiens Q99697-2
Validated Y2H
32296183
种属内
DYNLT1 P63172 DYNLT2B Homo sapiens Q8WW35
Validated Y2H
32296183
种属内
DYNLT1 P63172 DYNLT2B Homo sapiens Q8WW35
TAP
27173435
种属内
DYNLT1 P63172 CCDC68 Homo sapiens Q9H2F9
Validated Y2H
32296183
种属内
DYNLT1 P63172 NHSL2 Homo sapiens Q5HYW2
Validated Y2H
32296183
种属内
DYNLT1 P63172 UXT Homo sapiens Q9UBK9
Validated Y2H
32296183
种属内
DYNLT1 P63172 NEFL Homo sapiens P07196
Y2H Pooling
32814053
种属内
DYNLT1 P63172 NEFL Homo sapiens P07196
Validated Y2H
32814053
种属内
DYNLT1 P63172 NEFL Homo sapiens P07196
Y2H Array
32814053
种属内
DYNLT1 P63172 HSPB7 Homo sapiens Q9UBY9
Validated Y2H
32296183
种属内
DYNLT1 P63172 LNX1 Homo sapiens Q8TBB1
Validated Y2H
32296183
种属内
DYNLT1 P63172 NTAQ1 Homo sapiens Q96HA8
Validated Y2H
32296183
种属内
DYNLT1 P63172 DYNLT3 Homo sapiens P51808
TAP
27173435
种属内
DYNLT1 P63172 RRAGA Homo sapiens Q7L523
Validated Y2H
32296183
种属内
DYNLT1 P63172 KLK15 Homo sapiens Q9H2R5
Validated Y2H
32296183
种属内
DYNLT1 P63172 AARSD1 Homo sapiens Q9BTE6-2
Validated Y2H
32296183
种属内
DYNLT1 P63172 MARK1 Homo sapiens Q9P0L2
Validated Y2H
32296183
种属间
DYNLT1 P63172 gag Mason-Pfizer monkey virus P07567
Anti Bait CoIP
18647839
种属间: 跨种属相互作用 种属内: 同种属相互作用

DYNLT1 抗体

目录号 产品名 应用 反应物种
HY-P83518 Dynein Light Chain Tctex Type 1 Antibody (YA3263) WB, IHC-F, IHC-P, ICC/IF, IP Human, Mouse, Rat

关联疾病

疾病名称 别名
Glaucomatocyclitic Crisis

Posner-Schlossman Syndrome

Terrien-Viel Syndrome
Pulmonary Hypertension

Primary Pulmonary Hypertension

Hypertension Pulmonary

Hypertension, Pulmonary

Hypertension, Pulmonary, Primary

Idiopathic Pulmonary Hypertension

Idiopathic Pulmonary Arterial Hypertension

Pulmonary Htn - [Hypertension]
Nonparalytic Poliomyelitis

Acute Nonparalytic Poliomyelitis

Non-Paralytic Aseptic Meningitis
Neutrophilic Dermatosis, Acute Febrile

Sweet Syndrome

Acute Febrile Neutrophilic Dermatosis

Ss

AFND

Pyrin-Associated Autoinflammatory Disease

PAAND

Gomm-Button Disease

Sweet'S Syndrome

Gomm Button Disease

Sweets Syndrome

Acromelic Frontonasal Dysostosis

Sweet Disease
Paralytic Poliomyelitis

Poliomyelitis, Paralytic
Dermatitis, Atopic, 3

ATOD3

Dermatitis, Atopic, Susceptibility To, 3

Atopic Dermatitis 3

Dermatitis, Atopic, With Asthma

Dermatitis, Atopic 3

Atopic Dermatitis With Asthma
Lissencephaly

Pachygyria

Broad Gyri Of Cerebrum

Large Gyri Of Cerebrum

Macrogyria
Bardet-Biedl Syndrome

Bbs

Biedl-Bardet Syndrome
Behcet Syndrome

Behcet Disease

Behcet'S Syndrome

Behcet'S Disease

Behçet Disease

Bd

Adamantiades-Behcet Disease

Triple Symptom Complex

Behçet'S Disease

Behet'S Syndrome

Bd Syndrome

Behçet Syndrome

Behçet'S Syndrome

Behcet Triple Symptom Complex

Malignant Aphthosis

Old Silk Route Disease

Adamantiades-Behçet Disease
Primary Ciliary Dyskinesia

Immotile Cilia Syndrome

Kartagener Syndrome

Dextrocardia Bronchiectasis And Sinusitis

Pcd

Ciliary Motility Disorders

Ciliary Motility Disorder

Immotile Ciliary Syndrome

Ciliary Dyskinesia Primary

Ics

Polynesian Bronchiectasis

Dextrocardia-Bronchiectasis-Sinusitis Syndrome

Immotile Cilia Syndrome, Kartagener Type

Primary Ciliary Dyskinesia And Situs Inversus

Primary Ciliary Dyskinesia, Kartagener Type

Siewert Syndrome

Dyskinesia, Ciliary, Primary
Joubert Syndrome 1

Joubert Syndrome

Jbts

Cerebellooculorenal Syndrome 1

JBTS1

Joubert-Boltshauser Syndrome

Cerebelloparenchymal Disorder Iv

Cpd4

Cors1

Joubert Syndrome And Related Disorders

Jsrd

Familial Aplasia Of The Vermis

Joubert Syndrome Related Disorders

Js

Cerebellar Vermis Agenesis

Cerebelloparenchymal Disorder 4

Agenesis Of Cerebellar Vermis

Cerebello-Oculo-Renal Syndrome

Cors

Joubert-Bolthauser Syndrome

Cpd Iv

Classic Joubert Syndrome

Joubert Syndrome Type A

Pure Joubert Syndrome

Cerebello-Oculo-Renal Syndrome 1

Joubert Syndrome-1

Joubert Syndrome, Type 1

Joubert'S Syndrome
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS04092 DYNLT1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta DYNLT1 VGNC VGNC:81062
Felis catus DYNLT1 VGNC VGNC:61684
Rattus norvegicus DYNLT1 RGD RGD:620261
Canis familiaris DYNLT1 VGNC VGNC:54841
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