2. Gene
  3. DYNLT3 - dynein light chain Tctex-type 3 Gene

DYNLT3 - dynein light chain Tctex-type 3 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：动力蛋白轻链 Tctex-type 3

种属: Homo sapiens

同用名: RP3; TCTE1L; TCTEX1L

基因 ID: 6990 | 基因类型: protein coding

关于 DYNLT3

Cytogenetic location: Xp11.4 Genomic coordinates (GRCh38): X:37,838,836-37,847,571 (from NCBI)

功能概要

该基因编码动力蛋白轻链子类的成员。编码的蛋白质均二聚化并形成细胞质动力蛋白运动蛋白复合物的轻链成分。这种蛋白质对于将动力蛋白结合到特定货物 (包括纺锤体检查点蛋白 BUB3) 可能很重要。这种蛋白质也可以作为转录调节剂独立于动力蛋白发挥作用。在 2 号和 20 号染色体上发现了该基因的假基因。[RefSeq 提供，2010 年 3 月]

This gene encodes a member of a subclass of dynein light chains. The encoded protein homodimerizes and forms the light chain component of the cytoplasmic dynein motor protein complex. This protein may be important for binding dynein to specific cargos including the spindle checkpoint protein BUB3. This protein may also function independently of dynein as a transcriptional modulator. Pseudogenes of this gene are found on chromosomes 2 and 20.[provided by RefSeq, Mar 2010]

DYNLT3 基因产物(1)

mRNA Protein Name
NM_006520.3 NP_006511.1 dynein light chain Tctex-type 3
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables identical protein binding IPI
IPI: 通过物理相互作用推断
16189514 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
16189514 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of cytoplasmic dynein complex IDA
IDA: 通过直接分析推断
11425878 GOA
colocalizes with kinetochore IDA
IDA: 通过直接分析推断
17289665 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

DYNLT3 蛋白结构

Tctex-1

Tctex-1: Tctex-1 family (16 - 114)

  • 0
  • 100
  • 116 a.a.
蛋白主名 其他名称

dynein light chain Tctex-type 3

protein 91/23

DYNLT3 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
DYNLT3 P51808 DYNLT1 Homo sapiens P63172
Y2H Prey Pooling
32296183
种属内
DYNLT3 P51808 DYNLT1 Homo sapiens P63172
Validated Y2H
32296183
种属内
DYNLT3 P51808 DYNLT1 Homo sapiens P63172
Y2H Array
32296183
种属内
DYNLT3 P51808 DYNC1I2 Homo sapiens Q13409-3
Validated Y2H
32296183
种属内
DYNLT3 P51808 ZC3H14 Homo sapiens Q6PJT7-6
Y2H Prey Pooling
32296183
种属内
DYNLT3 P51808 ZC3H14 Homo sapiens Q6PJT7-6
Y2H Array
32296183
种属内
DYNLT3 P51808 ZC3H14 Homo sapiens Q6PJT7-6
Validated Y2H
32296183
种属内
DYNLT3 P51808 PMS1 Homo sapiens P54277-2
Validated Y2H
32296183
种属内
DYNLT3 P51808 C2orf15 Homo sapiens Q8WU43
Validated Y2H
32296183
种属内
DYNLT3 P51808 NIF3L1 Homo sapiens Q9GZT8
Validated Y2H
25416956
种属内
DYNLT3 P51808 NIF3L1 Homo sapiens Q9GZT8
Y2H Prey Pooling
25416956
种属内
DYNLT3 P51808 DYNLT3 Homo sapiens P51808
Y2H Array
32296183
种属内
DYNLT3 P51808 CCL28 Homo sapiens Q9NRJ3
Validated Y2H
32296183
种属内
DYNLT3 P51808 DYNLT3 Homo sapiens P51808
Y2H Pooling
16189514
种属内
DYNLT3 P51808 DYNLT3 Homo sapiens P51808
Validated Y2H
32296183
种属内
DYNLT3 P51808 DYNLT3 Homo sapiens P51808
Y2H Prey Pooling
32296183
种属内
DYNLT3 P51808 DYNLT3 Homo sapiens P51808
Y2H Array
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Mcleod Syndrome

Mcleod Neuroacanthocytosis Syndrome

MLS

X-Linked Mcleod Syndrome

Mcleod Phenotype

Neuroacanthocytosis, Mcleod Type

Mcleod Syndrome With Or Without Chronic Granulomatous Disease

MCLDS

Mcleod Type Neuroacanthocytosis

Mcleod Syndrome With Chronic Granulomatous Disease

Neuroacanthocytosis Mcleod Type

Blood Group Deletion Syndrome
Bardet-Biedl Syndrome 7

BBS7

Bardet-Biedl Syndrome, Type 7
Neuroacanthocytosis

Neuroacanthocytosis Syndrome
Retinitis Pigmentosa

RP

Rod-Cone Dystrophy

Autosomal Recessive Retinitis Pigmentosa

Non-Syndromic Retinitis Pigmentosa

Pericentral Pigmentary Retinopathy

Pigmentary Retinopathy

Tapetoretinal Degeneration

Rcd

Retinitis Pigmentosa Autosomal Recessive

ARRP

Retinitis Pigmentosa, Autosomal Recessive

Retinitis Pigmentosa 1
Asphyxiating Thoracic Dystrophy

Jeune Thoracic Dystrophy

Jeune Syndrome

Asphyxiating Thoracic Dysplasia

Short-Rib Thoracic Dysplasia With Or Without Polydactyly

Thoracic Pelvic Phalangeal Dystrophy

Asphyxiating Thoracic Chondrodystrophy

Atd

Chondroectodermal Dysplasia-Like Syndrome

Infantile Thoracic Dystrophy

Jeune Thoracic Dysplasia

Thoracic Asphyxiant Dystrophy

Thoracic-Pelvic-Phalangeal Dystrophy

Short-Rib Thoracic Dysplasia Without Polydactyly

Asphyxiating Thoracic Dystrophy Of The Newborn

Asphyxiating Thorax Dystrophy
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS04093 DYNLT3 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta DYNLT3 VGNC VGNC:106439
Canis familiaris DYNLT3 VGNC VGNC:40154
Bos taurus DYNLT3 VGNC VGNC:28278
Rattus norvegicus DYNLT3 RGD RGD:1549755
Mus musculus DYNLT3 MGD MGI:1914367
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