2. Gene
  3. MARK1 - microtubule affinity regulating kinase 1 Gene

MARK1 - microtubule affinity regulating kinase 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：微管亲和力调节激酶 1

种属: Homo sapiens

同用名: MARK; Par1c; Par-1c

基因 ID: 4139 | 基因类型: protein coding

关于 MARK1

Cytogenetic location: 1q41 Genomic coordinates (GRCh38): 1:220,528,136-220,664,461 (from NCBI)

This gene has 18 transcripts (splice variants), 230 orthologues and 3 paralogues. Broad expression in brain (RPKM 4.9), testis (RPKM 3.5) and 21 other tissues.

功能概要

启用多项功能，包括 ATP 绑定活动；磷脂结合活性；和蛋白激酶活性。参与细胞内信号转导和蛋白质磷酸化。位于细胞质中；树突;和质膜。 [由基因组资源联盟提供，2022 年 4 月]

Enables several functions, including ATP binding activity; phospholipid binding activity; and protein kinase activity. Involved in intracellular signal transduction and protein phosphorylation. Located in cytoplasm; dendrite; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

MARK1 基因产物(5)

mRNA Protein Name
NM_001286124.2 NP_001273053.1 serine/threonine-protein kinase MARK1 isoform 1
NM_001286126.2 NP_001273055.1 serine/threonine-protein kinase MARK1 isoform 3
NM_001286128.2 NP_001273057.1 serine/threonine-protein kinase MARK1 isoform 4
NM_001286129.2 NP_001273058.1 serine/threonine-protein kinase MARK1 isoform 5
NM_018650.5 NP_061120.3 serine/threonine-protein kinase MARK1 isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ATP binding IDA
IDA: 通过直接分析推断
14976552 GOA
enables magnesium ion binding IDA
IDA: 通过直接分析推断
14976552 GOA
enables phosphatidic acid binding IDA
IDA: 通过直接分析推断
21145462 GOA
enables phosphatidylinositol-4,5-bisphosphate binding IDA
IDA: 通过直接分析推断
21145462 GOA
enables phosphatidylserine binding IDA
IDA: 通过直接分析推断
21145462 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
23666762 GOA
enables protein serine/threonine kinase activity IDA
IDA: 通过直接分析推断
14976552 GOA
enables tau-protein kinase activity IMP
IMP: 通过突变表型推断
23666762 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in intracellular signal transduction IDA
IDA: 通过直接分析推断
14976552 GOA
involved in negative regulation of epithelial to mesenchymal transition IDA
IDA: 通过直接分析推断
31281935 GOA
acts upstream of negative regulation of gene expression IDA
IDA: 通过直接分析推断
31281935 GOA
acts upstream of positive regulation of gene expression IDA
IDA: 通过直接分析推断
31281935 GOA
involved in protein phosphorylation IDA
IDA: 通过直接分析推断
14976552 GOA
involved in protein phosphorylation IMP
IMP: 通过突变表型推断
23666762 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
23666762 GOA
located in dendrite IDA
IDA: 通过直接分析推断
23666762 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
21145462 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

MARK1 蛋白结构

Pkinase

Pkinase: Protein kinase domain (60 - 311)

KA1

KA1: Kinase associated domain 1 (750 - 795)

  • 0
  • 200
  • 400
  • 600
  • 795 a.a.
蛋白主名 其他名称

serine/threonine-protein kinase MARK1

MAP/microtubule affinity-regulating kinase 1

MARK1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
MARK1 Q9P0L2 DYNLT1 Homo sapiens P63172
Y2H Prey Pooling
32296183
种属内
MARK1 Q9P0L2 DYNLT1 Homo sapiens P63172
Y2H Array
32296183
种属内
MARK1 Q9P0L2 YAF2 Homo sapiens Q8IY57-5
Y2H Prey Pooling
32296183
种属内
MARK1 Q9P0L2 YAF2 Homo sapiens Q8IY57-5
Y2H Array
32296183
种属内
MARK1 Q9P0L2 INCA1 Homo sapiens Q0VD86
Y2H Array
32296183
种属内
MARK1 Q9P0L2 INCA1 Homo sapiens Q0VD86
Y2H Prey Pooling
32296183
种属内
MARK1 Q9P0L2 TCL1B Homo sapiens O95988
Y2H Prey Pooling
32296183
种属内
MARK1 Q9P0L2 TCL1B Homo sapiens O95988
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Peutz-Jeghers Syndrome

PJS

Polyposis, Hamartomatous Intestinal

Polyps-And-Spots Syndrome

Lentiginosis, Perioral

Periorificial Lentiginosis Syndrome

Hamartomatous Intestinal Polyposis

Hamartomatous Polyp

Colonic Hamartomatous Polyp

Gastric Peutz-Jeghers Polyp

Peutz Jeghers Colon Polyp

Peutz Jeghers Polyp

Peutz-Jeghers Polyp Of Small Intestine

Peutz-Jeghers Small Bowel Hamartoma

Peutz Jeghers Polyposis

Intestinal Polyposis-Cutaneous Pigmentation Syndrome

Peutz-Jeghers Polyposis

Polyposis, Intestinal, Ii

Intestinal Hamartomatous Polyposis

Peutz-Jeghers Polyp

Peutz-Jeghers Polyp Of The Stomach

Peutz Jehgers Polyp

Peutz-Jeghers Polyps Of Small Bowel
Autism

Autistic Disorder

Autism Susceptibility 1

Childhood Autism

Autistic Disorder Of Childhood Onset

Infantile Autism

Kanner'S Syndrome

Autistic
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-120877 MRT199665 99.74% 否
HY-139604 PCC0208017 99.56% 否
HY-120877A (R)-MRT199665 98.70% 否
HY-RS08149 MARK1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus MARK1 RGD RGD:619882
Canis familiaris MARK1 VGNC VGNC:49921
Felis catus MARK1 VGNC VGNC:68184
Macaca mulatta MARK1 VGNC VGNC:74658
Mus musculus MARK1 MGD MGI:2664902
Bos taurus MARK1 VGNC VGNC:103721
Others MARK1 NCBI
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