2. Gene
  3. TCL1B - TCL1 family AKT coactivator B Gene

TCL1B - TCL1 family AKT coactivator B Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：TCL1 家族 AKT 共激活因子 B

种属: Homo sapiens

同用名: TML1; SYN-1

基因 ID: 9623 | 基因类型: protein coding

关于 TCL1B

Cytogenetic location: 14q32.13 Genomic coordinates (GRCh38): 14:95,686,426-95,692,628 (from NCBI)

This gene has 3 transcripts (splice variants), 94 orthologues and 2 paralogues. Biased expression in testis (RPKM 1.5), lymph node (RPKM 1.2) and 6 other tissues.

功能概要

启用蛋白激酶结合活性和蛋白丝氨酸/苏氨酸激酶激活剂活性。参与肽酰丝氨酸磷酸化的正向调节和蛋白丝氨酸/苏氨酸激酶活性的正向调节。部分含蛋白质复合物。 [由基因组资源联盟提供，2022 年 4 月]

Enables protein kinase binding activity and protein serine/threonine kinase activator activity. Involved in positive regulation of peptidyl-serine phosphorylation and positive regulation of protein serine/threonine kinase activity. Part of protein-containing complex. [provided by Alliance of Genome Resources, Apr 2022]

TCL1B 基因产物(1)

mRNA Protein Name
NM_004918.4 NP_004909.1 T-cell leukemia/lymphoma protein 1B
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
enables protein kinase binding IPI
IPI: 通过物理相互作用推断
10983986 GOA
enables protein serine/threonine kinase activator activity IDA
IDA: 通过直接分析推断
10983986 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in intracellular signal transduction IDA
IDA: 通过直接分析推断
10983986 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TCL1B 蛋白结构

TCL1_MTCP1

TCL1_MTCP1: TCL1/MTCP1 family (1 - 124)

  • 0
  • 100
  • 128 a.a.
蛋白主名 其他名称

T-cell leukemia/lymphoma protein 1B

T cell leukemia/lymphoma 1B

TCL1B 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
TCL1B O95988 PLEKHA3 Homo sapiens Q9HB20
Y2H Prey Pooling
32296183
种属内
TCL1B O95988 PLEKHA3 Homo sapiens Q9HB20
Validated Y2H
32296183
种属内
TCL1B O95988 PLEKHA3 Homo sapiens Q9HB20
Y2H Array
32296183
种属内
TCL1B O95988 EFCAB2 Homo sapiens Q5VUJ9-2
Y2H Prey Pooling
32296183
种属内
TCL1B O95988 EFCAB2 Homo sapiens Q5VUJ9-2
Validated Y2H
32296183
种属内
TCL1B O95988 EFCAB2 Homo sapiens Q5VUJ9-2
Y2H Array
32296183
种属内
TCL1B O95988 MEIS3 Homo sapiens Q99687-3
Validated Y2H
32296183
种属内
TCL1B O95988 MEIS3 Homo sapiens Q99687-3
Y2H Prey Pooling
32296183
种属内
TCL1B O95988 MEIS3 Homo sapiens Q99687-3
Y2H Array
32296183
种属内
TCL1B O95988 MKRN3 Homo sapiens Q13064
Validated Y2H
32296183
种属内
TCL1B O95988 MKRN3 Homo sapiens Q13064
Y2H Prey Pooling
32296183
种属内
TCL1B O95988 MKRN3 Homo sapiens Q13064
Y2H Array
32296183
种属内
TCL1B O95988 BAG4 Homo sapiens O95429
Y2H Array
32296183
种属内
TCL1B O95988 BAG4 Homo sapiens O95429
Y2H Prey Pooling
32296183
种属内
TCL1B O95988 PNMA1 Homo sapiens Q8ND90
Validated Y2H
32296183
种属内
TCL1B O95988 PNMA1 Homo sapiens Q8ND90
Y2H Prey Pooling
32296183
种属内
TCL1B O95988 PNMA1 Homo sapiens Q8ND90
Y2H Array
32296183
种属内
TCL1B O95988 LSM7 Homo sapiens Q9UK45
Validated Y2H
32296183
种属内
TCL1B O95988 LSM5 Homo sapiens Q9Y4Y9
Validated Y2H
32296183
种属内
TCL1B O95988 ZNF330 Homo sapiens Q9Y3S2
Y2H Prey Pooling
32296183
种属内
TCL1B O95988 ZNF330 Homo sapiens Q9Y3S2
Validated Y2H
32296183
种属内
TCL1B O95988 ZNF330 Homo sapiens Q9Y3S2
Y2H Array
32296183
种属内
TCL1B O95988 GLRX3 Homo sapiens O76003
Y2H Prey Pooling
32296183
种属内
TCL1B O95988 GLRX3 Homo sapiens O76003
Y2H Array
32296183
种属内
TCL1B O95988 SNRPG Homo sapiens P62308
Validated Y2H
32296183
种属内
TCL1B O95988 MARK1 Homo sapiens Q9P0L2
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Leukemia

Leukemias

Leukaemia, Unspecified, Without Mention Of Remission

Aleukemic Leukaemia

Chronic Leukaemia

Subacute Leukaemia

Leukaemia Disorder

Leukaemia Nos
Lymphoma

Lymphoid Cancer

Lymphomas

Lymphoid Cancers

Lymphoid Neoplasm

Lymphoma Nos

Nhl - [Non-Hodgkin Lymphoma]

Non-Hodgkin Lymphoma

Non-Hodgkin Lymphoma, Nos

Non-Hodgkin Malignant Lymphoma Nos
T-Cell Prolymphocytic Leukemia

T Cell Prolymphocytic Leukemia

Prolymphocytic Leukemia, T-Cell Type

T-Pll

T-Cell Chronic Lymphocytic Leukemia

Lymphocytic Leukemia T-Cell Chronic

Doid:0081042

Leukemia, T-Cell, Chronic

Prolymphocytic Leukaemia Of T-Cell Type Without Mention Of Remission
T-Cell Acute Lymphoblastic Leukemia

T-Cell Leukemia

Acute T Cell Leukemia

Precursor T Lymphoblastic Leukemia

Precursor T-Lymphoblastic Lymphoma/Leukemia

T Acute Lymphoblastic Leukemia

T-Cell Acute Lymphocytic Leukaemia

T-Cell Lymphoblastic Leukemia/Lymphoma

Leukemia T-Cell

Leukemia, T-Cell

Leukemia, Acute, Lymphoblastic, T-Cell

Leukemia, T-Cell Acute Lymphoblastic

Leukemia, Acute T-Cell

Precursor T-Cell Lymphoblastic Leukemia-Lymphoma

Precursor T-Cell Lymphoblastic Lymphoma

Precursor T Cell Lymphoblastic Leukemia/Lymphoblastic Lymphoma
Bn2 Diffuse Large B-Cell Lymphoma

Bn2 Dlbcl

Doid:0081064
Richter'S Syndrome

Richter Syndrome

Richter Transformation
Prolymphocytic Leukemia

Pll

Prolymphocytic Leukaemia

Leukemia Prolymphocytic

Leukemia, Prolymphocytic
Splenic Manifestation Of Leukemia

Splenic Leukemia
Mantle Cell Lymphoma

Lymphoma, Mantle Cell

Lcm

Mcl

Mantle Zone Lymphoma

Lymphoma Mantle-Cell

Lymphoma, Mantle-Cell

Malignant Lymphoma, Lymphocytic, Intermediate Differentiation, Diffuse

Malignant Lymphoma - Lymphocytic, Intermediate Differentiation

Diffuse Small Cleaved-Cell Lymphoma

Diffuse Small Cleaved Cell Malignant Lymphoma

Small Cleaved Cell Non-Hodgkin Lymphoma

Diffuse Non-Hodgkin Small Cleaved Cell Lymphoma

Malignant Lymphomatous Polyposis

Malignant Small Cell, Noncleaved, Diffuse Lymphoma

Malignant Undifferentiated Cell, Non-Burkitt Lymphoma

Cleaved Cell Lymphoma

Small Cell Mantle Cell Lymphoma

Small Cleaved Cell Malignant Lymphoma
Leukemia, Chronic Lymphocytic

Chronic Lymphocytic Leukemia

B-Cell Chronic Lymphocytic Leukemia

CLL

B-Cell Chronic Lymphoid Leukemia

Chronic Lymphatic Leukemia

Chronic Lymphocytic Leukaemia

Lymphoplasmacytic Leukemia

Small Lymphocytic Lymphoma

Leukemia, Chronic Lymphatic

B-Cell Chronic Lymphocytic Leukaemia

Chronic Lymphatic Leukaemia

Lymphoplasmacytic Leukaemia

B Cell Chronic Lymphocytic Leukemia

Chronic B-Cell Lymphocytic Leukemia

Leukemia, Lymphocytic, Chronic

B-Cll

Chronic Lymphoid Leukemia

Leukemia Lymphocytic Chronic

Lymphoma Small Lymphocytic

Leukemia, Lymphocytic, Chronic, B-Cell
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS14317 TCL1B Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta TCL1B VGNC VGNC:99736
Bos taurus TCL1B VGNC VGNC:99735
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