2. Gene
  3. LSM5 - LSM5 homolog, U6 small nuclear RNA and mRNA degradation associated Gene

LSM5 - LSM5 homolog, U6 small nuclear RNA and mRNA degradation associated Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：LSM5 同系物、U6 小核 RNA 和 mRNA 降解相关

种属: Homo sapiens

同用名: YER146W

基因 ID: 23658 | 基因类型: protein coding

关于 LSM5

Cytogenetic location: 7p14.3 Genomic coordinates (GRCh38): 7:32,485,338-32,495,283 (from NCBI)

This gene has 10 transcripts (splice variants) and 218 orthologues. Ubiquitous expression in thyroid (RPKM 6.1), colon (RPKM 6.1) and 25 other tissues.

功能概要

基于与 Sm 蛋白家族的序列同源性，在多种生物体中鉴定出 Sm 样蛋白 (参见 SNRPD2；MIM 601061) 。 Sm 样蛋白包含 Sm 序列基序，该基序由 2 个区域组成，该区域由折叠成环的可变长度接头隔开。 Sm 样蛋白被认为形成了存在于 tri-snRNP 颗粒中的稳定异聚体，这对于 pre-mRNA 剪接很重要。[OMIM 提供，2004 年 4 月]

Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; MIM 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.[supplied by OMIM, Apr 2004]

LSM5 基因产物(3)

mRNA Protein Name
NM_001130710.2 NP_001124182.1 U6 snRNA-associated Sm-like protein LSm5 isoform b
NM_001139499.2 NP_001132971.1 U6 snRNA-associated Sm-like protein LSm5 isoform b
NM_012322.3 NP_036454.1 U6 snRNA-associated Sm-like protein LSm5 isoform a
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
15231747 GOA
enables protein heterodimerization activity IDA
IDA: 通过直接分析推断
12515382 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within mRNA catabolic process IDA
IDA: 通过直接分析推断
12515382 GOA
involved in mRNA splicing, via spliceosome IDA
IDA: 通过直接分析推断
28781166 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of Lsm2-8 complex IDA
IDA: 通过直接分析推断
10523320 GOA
part of U2-type precatalytic spliceosome IDA
IDA: 通过直接分析推断
28781166 GOA
part of U4/U6 x U5 tri-snRNP complex IDA
IDA: 通过直接分析推断
26912367 GOA
part of U4/U6 x U5 tri-snRNP complex IPI
IPI: 通过物理相互作用推断
30975767 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
12515382 GOA
located in nucleus IDA
IDA: 通过直接分析推断
26912367 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

LSM5 蛋白结构

LSM

LSM: LSM domain (18 - 84)

  • 0
  • 91 a.a.
蛋白主名 其他名称

U6 snRNA-associated Sm-like protein LSm5

LSM5 U6 small nuclear RNA and mRNA degradation associated

LSM5 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra LSM5 Q9Y4Y9 SPMIP10 Homo sapiens Q6ZNM6
Y2H Prey Pooling
32296183
Intra LSM5 Q9Y4Y9 SPMIP10 Homo sapiens Q6ZNM6
Y2H Array
32296183
Intra LSM5 Q9Y4Y9 SNRPE Homo sapiens P62304
Y2H Prey Pooling
32296183
Intra LSM5 Q9Y4Y9 SNRPE Homo sapiens P62304
Y2H
15231747
Intra LSM5 Q9Y4Y9 SNRPE Homo sapiens P62304
Y2H Array
32296183
Intra LSM5 Q9Y4Y9 LSM3 Homo sapiens P62310
Y2H
15231747
Intra LSM5 Q9Y4Y9 LSM3 Homo sapiens P62310
Y2H Array
32296183
Intra LSM5 Q9Y4Y9 LSM3 Homo sapiens P62310
Anti Tag CoIP
33961781
Intra LSM5 Q9Y4Y9 LSM3 Homo sapiens P62310
Y2H Prey Pooling
32296183
Intra LSM5 Q9Y4Y9 LSM7 Homo sapiens Q9UK45
Y2H Array
32296183
Intra LSM5 Q9Y4Y9 LSM7 Homo sapiens Q9UK45
Y2H Prey Pooling
25416956
Intra LSM5 Q9Y4Y9 LSM7 Homo sapiens Q9UK45
Y2H
15231747
Intra LSM5 Q9Y4Y9 LSM7 Homo sapiens Q9UK45
Y2H Prey Pooling
32296183
Intra LSM5 Q9Y4Y9 LSM7 Homo sapiens Q9UK45
Y2H Array
31515488
Intra LSM5 Q9Y4Y9 LSM7 Homo sapiens Q9UK45
Validated Y2H
25416956
Intra LSM5 Q9Y4Y9 LSM7 Homo sapiens Q9UK45
Y2H
22365833
Intra LSM5 Q9Y4Y9 LSM7 Homo sapiens Q9UK45
Y2H Array
25416956
Intra LSM5 Q9Y4Y9 LSM7 Homo sapiens Q9UK45
Anti Tag CoIP
33961781
Intra LSM5 Q9Y4Y9 SNRPF Homo sapiens P62306
Y2H
22365833
Intra LSM5 Q9Y4Y9 SNRPF Homo sapiens P62306
Anti Tag CoIP
33961781
Intra LSM5 Q9Y4Y9 SNRPF Homo sapiens P62306
Y2H Array
32296183
Intra LSM5 Q9Y4Y9 SNRPF Homo sapiens P62306
Y2H
15231747
Intra LSM5 Q9Y4Y9 SNRPF Homo sapiens P62306
Y2H Prey Pooling
32296183
Intra LSM5 Q9Y4Y9 SNRPF Homo sapiens P62306
Validated Y2H
25416956
Intra LSM5 Q9Y4Y9 LSM6 Homo sapiens P62312
Y2H Array
25416956
Intra LSM5 Q9Y4Y9 LSM6 Homo sapiens P62312
Y2H
15231747
Intra LSM5 Q9Y4Y9 LSM6 Homo sapiens P62312
Y2H Array
32296183
Intra LSM5 Q9Y4Y9 LSM6 Homo sapiens P62312
Y2H Prey Pooling
32296183
Intra LSM5 Q9Y4Y9 TBPL1 Homo sapiens P62380
Y2H Prey Pooling
32296183
Intra LSM5 Q9Y4Y9 TBPL1 Homo sapiens P62380
Y2H Array
32296183
Intra LSM5 Q9Y4Y9 TCL1B Homo sapiens O95988
Y2H Array
32296183
Intra LSM5 Q9Y4Y9 TCL1B Homo sapiens O95988
Y2H Prey Pooling
32296183
Intra LSM5 Q9Y4Y9 DDIT4L Homo sapiens Q96D03
Y2H Prey Pooling
32296183
Intra LSM5 Q9Y4Y9 DDIT4L Homo sapiens Q96D03
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Spinal Muscular Atrophy

Sma

5q Sma

Proximal Sma

Sma-Associated Sma

Spinal Amyotrophies

Spinal Amyotrophy

Spinal Muscle Degeneration

Spinal Muscle Wasting

Muscular Atrophy Spinal

Atrophy, Muscular, Spinal

Hereditary Motor Neuronopathy

Progressive Muscular Atrophy

Sma - [Spinal Muscular Atrophy]
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS07860 LSM5 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus LSM5 RGD RGD:1308655
Felis catus LSM5 VGNC VGNC:80617
Macaca mulatta LSM5 VGNC VGNC:108418
Mus musculus LSM5 MGD MGI:1913623
Bos taurus LSM5 VGNC VGNC:31057
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