TBPL1 - TATA-box binding protein like 1 Gene

中文名称：TATA-box 结合蛋白样 1

种属: Homo sapiens

同用名: TLF; TLP; STUD; TRF2; MGC:8389; MGC:9620

关于 TBPL1

功能概要

该基因编码 TATA 盒结合蛋白家族的成员。 TATA 盒结合蛋白作为转录因子 IID (TFIID) 复合物的组分，在 RNA 聚合酶 II 的转录中起着至关重要的作用。编码的蛋白质不与 TATA 盒结合并从无 TATA 启动子启动转录。该基因在精子发生中起关键作用，该基因的单核苷酸多态性可能与男性不育有关。已观察到该基因的选择性剪接转录变体，该基因的假基因位于 3 号染色体的长臂上。[RefSeq 提供，2011 年 11 月]

This gene encodes a member of the TATA box-binding protein family. TATA box-binding proteins play a critical role in transcription by RNA polymerase II as components of the transcription factor IID (TFIID) complex. The encoded protein does not bind to the TATA box and initiates transcription from TATA-less promoters. This gene plays a critical role in spermatogenesis, and single nucleotide polymorphisms in this gene may be associated with male infertility. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 3. [provided by RefSeq, Nov 2011]