1. Gene
  2. LSM6 - LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated Gene

LSM6 - LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated Gene

中文名称:LSM6 同系物、U6 小核 RNA 和 mRNA 降解相关

种属: Homo sapiens

同用名: YDR378C

基因 ID: 11157 | 基因类型: protein coding

关于 LSM6

Cytogenetic location: 4q31.22 Genomic coordinates (GRCh38): 4:146,175,718-146,191,535 (from NCBI)

This gene has 8 transcripts (splice variants), 225 orthologues and 1 paralogue. Ubiquitous expression in fat (RPKM 5.0), lymph node (RPKM 4.2) and 25 other tissues.

功能概要

基于与 Sm 蛋白家族的序列同源性,在多种生物体中鉴定出 Sm 样蛋白 (参见 SNRPD2;MIM 601061) 。 Sm 样蛋白包含 Sm 序列基序,该基序由 2 个区域组成,该区域由折叠成环的可变长度接头隔开。 Sm 样蛋白被认为形成了存在于 tri-snRNP 颗粒中的稳定异聚体,这对于 pre-mRNA 剪接很重要。[OMIM 提供,2004 年 4 月]

Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; MIM 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.[supplied by OMIM, Apr 2004]

LSM6 基因产物(1)

mRNA Protein Name
NM_007080.3 NP_009011.1 U6 snRNA-associated Sm-like protein LSm6
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
15231747 GOA
enables protein heterodimerization activity IDA
IDA: 通过直接分析推断
12515382 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within mRNA catabolic process IDA
IDA: 通过直接分析推断
12515382 GOA
involved in mRNA splicing, via spliceosome IDA
IDA: 通过直接分析推断
28781166 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of Lsm2-8 complex IDA
IDA: 通过直接分析推断
10523320 GOA
part of U2-type precatalytic spliceosome IDA
IDA: 通过直接分析推断
28781166 GOA
part of U4/U6 x U5 tri-snRNP complex IDA
IDA: 通过直接分析推断
26912367 GOA
part of U4/U6 x U5 tri-snRNP complex IPI
IPI: 通过物理相互作用推断
30975767 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
12515382 GOA
located in nucleus IDA
IDA: 通过直接分析推断
26912367 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

LSM6 蛋白结构

LSM

LSM: LSM domain (11 - 74)

  • 0
  • 80 a.a.
蛋白主名 其他名称

U6 snRNA-associated Sm-like protein LSm6

LSM6 U6 small nuclear RNA and mRNA degradation associated

LSM6 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
LSM6 P62312 PATL1 Homo sapiens Q86TB9 33961781
种属内
LSM6 P62312 PATL1 Homo sapiens Q86TB9 32296183
种属内
LSM6 P62312 SNRPD2 Homo sapiens P62316 33961781
种属内
LSM6 P62312 SNRPD2 Homo sapiens P62316 28514442
种属内
LSM6 P62312 SNRPD2 Homo sapiens P62316
Y2H
15231747
种属内
LSM6 P62312 LSM2 Homo sapiens Q9Y333 33961781
种属内
LSM6 P62312 LSM2 Homo sapiens Q9Y333 28514442
种属内
LSM6 P62312 LSM2 Homo sapiens Q9Y333 32296183
种属内
LSM6 P62312 LSM1 Homo sapiens O15116 33961781
种属内
LSM6 P62312 LSM1 Homo sapiens O15116 28514442
种属内
LSM6 P62312 LSM1 Homo sapiens O15116
Y2H
15231747
种属内
LSM6 P62312 LSM8 Homo sapiens O95777 33961781
种属内
LSM6 P62312 LSM8 Homo sapiens O95777
Y2H
15231747
种属内
LSM6 P62312 LSM8 Homo sapiens O95777 28514442
种属内
LSM6 P62312 LSM3 Homo sapiens P62310 28514442
种属内
LSM6 P62312 LSM3 Homo sapiens P62310 25416956
种属内
LSM6 P62312 LSM3 Homo sapiens P62310 32296183
种属内
LSM6 P62312 LSM3 Homo sapiens P62310
Y2H
15231747
种属内
LSM6 P62312 LSM3 Homo sapiens P62310 32296183
种属内
LSM6 P62312 LSM3 Homo sapiens P62310 33961781
种属内
LSM6 P62312 LSM7 Homo sapiens Q9UK45 33961781
种属内
LSM6 P62312 LSM7 Homo sapiens Q9UK45 28514442
种属内
LSM6 P62312 LSM7 Homo sapiens Q9UK45
Y2H
15231747
种属内
LSM6 P62312 SNRPF Homo sapiens P62306
Y2H
22365833
种属内
LSM6 P62312 LSM5 Homo sapiens Q9Y4Y9 25416956
种属内
LSM6 P62312 LSM5 Homo sapiens Q9Y4Y9 25416956
种属内
LSM6 P62312 LSM5 Homo sapiens Q9Y4Y9 33961781
种属内
LSM6 P62312 LSM5 Homo sapiens Q9Y4Y9 32296183
种属内
LSM6 P62312 LSM5 Homo sapiens Q9Y4Y9 32296183
种属内
LSM6 P62312 LSM5 Homo sapiens Q9Y4Y9
Y2H
15231747
种属内
LSM6 P62312 LSM5 Homo sapiens Q9Y4Y9 32296183
种属内
LSM6 P62312 LSM5 Homo sapiens Q9Y4Y9
Y2H
22365833
种属内
LSM6 P62312 CLNS1A Homo sapiens P54105 32296183
种属内
LSM6 P62312 CLNS1A Homo sapiens P54105
Y2H
22365833
种属内
LSM6 P62312 CLNS1A Homo sapiens P54105 33961781
种属内
LSM6 P62312 CLNS1A Homo sapiens P54105 25416956
种属内
LSM6 P62312 CLNS1A Homo sapiens P54105 32296183
种属内
LSM6 P62312 CLNS1A Homo sapiens P54105 28514442
种属内
LSM6 P62312 SDCBP Homo sapiens O00560 32296183
种属内
LSM6 P62312 SDCBP Homo sapiens O00560 25416956
种属内
LSM6 P62312 SDCBP Homo sapiens O00560 25416956
种属内
LSM6 P62312 SDCBP Homo sapiens O00560 32296183
种属内
LSM6 P62312 SDCBP Homo sapiens O00560 25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Spinal Muscular Atrophy

Sma

5q Sma

Proximal Sma

Sma-Associated Sma

Spinal Amyotrophies

Spinal Amyotrophy

Spinal Muscle Degeneration

Spinal Muscle Wasting

Muscular Atrophy Spinal

Atrophy, Muscular, Spinal

Hereditary Motor Neuronopathy

Progressive Muscular Atrophy

Sma - [Spinal Muscular Atrophy]

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Felis catus LSM6 VGNC VGNC:63324
Rattus norvegicus LSM6 RGD RGD:1561937
Canis familiaris LSM6 VGNC VGNC:42845
Macaca mulatta LSM6 VGNC VGNC:107181
Mus musculus LSM6 MGD MGI:1925901
Bos taurus LSM6 VGNC VGNC:31058