LSM8 - LSM8 homolog, U6 small nuclear RNA associated Gene

中文名称：LSM8 同源物，U6 小核 RNA 相关

种属: Homo sapiens

同用名: NAA38

基因 ID: 51691 | 基因类型: protein coding

关于 LSM8

Cytogenetic location: 7q31.31 Genomic coordinates (GRCh38): 7:118,184,164-118,204,035 (from NCBI)

This gene has 4 transcripts (splice variants), 201 orthologues and 1 paralogue. Ubiquitous expression in lymph node (RPKM 1.1), spleen (RPKM 0.9) and 25 other tissues.

功能概要

该基因编码 like-Sm 蛋白家族的成员。编码的蛋白质由一个封闭的桶形组成，由五个反平行的 β 链和一个 α 螺旋组成。这种蛋白质与六个旁系同源物结合形成一个异七聚体环，该环瞬时结合 U6 小核 RNA，并参与细胞核中 RNA 的一般成熟。[RefSeq 提供，2010 年 1 月]

This gene encodes a member of the like-Sm family of proteins. The encoded protein consists of a closed barrel shape, made up of five anti-parallel beta strands and an alpha helix. This protein partners with six paralogs to form a heteroheptameric ring which transiently binds U6 small nuclear RNAs and is involved in the general maturation of RNA in the nucleus. [provided by RefSeq, Jan 2010]

LSM8 基因产物(1)

mRNA	Protein	Name
NM_016200.5	NP_057284.1	LSM8 homolog, U6 small nuclear RNA associated

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	14667819	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in mRNA splicing, via spliceosome	IDA IDA: 通过直接分析推断	28781166	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of Lsm2-8 complex	IDA IDA: 通过直接分析推断	10523320	GOA
part of U2-type precatalytic spliceosome	IDA IDA: 通过直接分析推断	28781166	GOA
part of U4/U6 x U5 tri-snRNP complex	IDA IDA: 通过直接分析推断	26912367	GOA
part of U4/U6 x U5 tri-snRNP complex	IPI IPI: 通过物理相互作用推断	30975767	GOA
located in nucleus	IDA IDA: 通过直接分析推断	26912367	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

LSM8 蛋白结构

LSM

0
96 a.a.

蛋白主名

其他名称

LSM8 homolog, U6 small nuclear RNA associated

LSM8 U6 small nuclear RNA associated

LSM8 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	LSM8	O95777	LSM2	Homo sapiens	Q9Y333	Y2H	15231747
种属内	LSM8	O95777	LSM3	Homo sapiens	P62310	Y2H	15231747
种属内	LSM8	O95777	LSM7	Homo sapiens	Q9UK45	Y2H	15231747
种属内	LSM8	O95777	LSM4	Homo sapiens	Q9Y4Z0	Y2H	15231747
种属内	LSM8	O95777	TARDBP	Homo sapiens	Q13148	Validated Y2H	32814053
种属内	LSM8	O95777	TARDBP	Homo sapiens	Q13148	Y2H Pooling	32814053
种属内	LSM8	O95777	TARDBP	Homo sapiens	Q13148	Y2H Array	32814053
种属内	LSM8	O95777	LSM6	Homo sapiens	P62312	Y2H	15231747
种属内	LSM8	O95777	HTT	Homo sapiens	P42858	Y2H Array	32814053
种属内	LSM8	O95777	HTT	Homo sapiens	P42858	Validated Y2H	32814053
种属内	LSM8	O95777	HTT	Homo sapiens	P42858	Y2H Pooling	32814053
种属内	LSM8	O95777	PMP22	Homo sapiens	A0A6Q8PF08	Y2H Array	32814053
种属内	LSM8	O95777	PMP22	Homo sapiens	A0A6Q8PF08	Y2H Pooling	32814053
种属内	LSM8	O95777	PMP22	Homo sapiens	A0A6Q8PF08	Validated Y2H	32814053
种属内	LSM8	O95777	SNCA	Homo sapiens	P37840	Validated Y2H	32814053
种属内	LSM8	O95777	SNCA	Homo sapiens	P37840	Y2H Array	32814053
种属内	LSM8	O95777	SNCA	Homo sapiens	P37840	Y2H Pooling	32814053
种属内	LSM8	O95777	SOD1	Homo sapiens	P00441	Validated Y2H	32814053
种属内	LSM8	O95777	SOD1	Homo sapiens	P00441	Y2H Pooling	32814053
种属内	LSM8	O95777	SOD1	Homo sapiens	P00441	Y2H Array	32814053

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Night Blindness, Congenital Stationary, Autosomal Dominant 1

Congenital Stationary Night Blindness Autosomal Dominant 1	CSNBAD1
Rhodopsin-Related Congenital Stationary Night Blindness	Night Blindness, Congenital Stationary, Rhodopsin-Related
Blindness, Night, Stationary, Congenital, Autosomal Dominant, Type 1

Poikiloderma With Neutropenia

Poikiloderma With Neutropenia, Clericuzio Type	PN
Clericuzio Type Poikiloderma With Neutropenia	Poikiloderma With Neutropenia, Clericuzio-Type
Clericuzio-Type Poikiloderma With Neutropenia	Poikiloderma With Neutropenia Clericuzio Type
Immune-Deficient Poikiloderma	Clericuzio-Type Poikiloderma Neutropenia Syndrome
Poikiloderma With Neutropenia Clericuzio-Type	Poikiloderma, With Neutropenia

Retinitis Pigmentosa

RP	Rod-Cone Dystrophy
Autosomal Recessive Retinitis Pigmentosa	Non-Syndromic Retinitis Pigmentosa
Pericentral Pigmentary Retinopathy	Pigmentary Retinopathy
Tapetoretinal Degeneration	Rcd
Retinitis Pigmentosa Autosomal Recessive	ARRP
Retinitis Pigmentosa, Autosomal Recessive	Retinitis Pigmentosa 1

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS07863	LSM8 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	LSM8	VGNC	VGNC:80618
Macaca mulatta	LSM8	VGNC	VGNC:81636
Bos taurus	LSM8	VGNC	VGNC:31060
Mus musculus	LSM8	MGD	MGI:1923772
Canis familiaris	LSM8	VGNC	VGNC:49756
Rattus norvegicus	LSM8	RGD	RGD:1308442

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