PELO - pelota mRNA surveillance and ribosome rescue factor Gene

中文名称：pelota mRNA 监测和核糖体拯救因子

种属: Homo sapiens

同用名: CGI-17; PRO1770

基因 ID: 53918 | 基因类型: protein coding

关于 PELO

Cytogenetic location: 5q11.2 Genomic coordinates (GRCh38): 5:52,787,916-52,804,044 (from NCBI)

This gene has 2 transcripts (splice variants) and 189 orthologues. Ubiquitous expression in adrenal (RPKM 14.2), spleen (RPKM 12.3) and 25 other tissues.

功能概要

该基因编码一种含有保守核定位信号的蛋白质。编码的蛋白质可能在精子发生、细胞周期控制和减数分裂细胞分裂中发挥作用。[RefSeq 提供，2008 年 7 月]

This gene encodes a protein which contains a conserved nuclear localization signal. The encoded protein may have a role in spermatogenesis, cell cycle control, and in meiotic cell division. [provided by RefSeq, Jul 2008]

PELO 基因产物(1)

mRNA	Protein	Name
NM_015946.5	NP_057030.3	protein pelota homolog

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	20406461	GOA
enables ribosome binding	IDA IDA: 通过直接分析推断	27543824	GOA
enables stalled ribosome sensor activity	IDA IDA: 通过直接分析推断	27863242	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in nuclear-transcribed mRNA catabolic process, no-go decay	IDA IDA: 通过直接分析推断	23667253	GOA
involved in rescue of stalled ribosome	IDA IDA: 通过直接分析推断	21448132	GOA
involved in ribosome disassembly	IDA IDA: 通过直接分析推断	21448132	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of Dom34-Hbs1 complex	IDA IDA: 通过直接分析推断	27863242	GOA
is active in cytosolic ribosome	IDA IDA: 通过直接分析推断	27863242	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PELO 蛋白结构

eRF1_1

eRF1_2

eRF1_3

0
100
200
300
385 a.a.

蛋白主名

其他名称

protein pelota homolog

pelota homolog

PELO 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	PELO	Q9BRX2	KRTAP12-2	Homo sapiens	P59991	Y2H Array	32296183
Intra	PELO	Q9BRX2	KRTAP12-2	Homo sapiens	P59991	Y2H Prey Pooling	32296183
Intra	PELO	Q9BRX2	ICAM1	Homo sapiens	P05362	Validated Y2H	32814053
Intra	PELO	Q9BRX2	ICAM1	Homo sapiens	P05362	Y2H Array	32814053
Intra	PELO	Q9BRX2	ICAM1	Homo sapiens	P05362	Y2H Pooling	32814053
Intra	PELO	Q9BRX2	MAT2A	Homo sapiens	P31153	Validated Y2H	32814053
Intra	PELO	Q9BRX2	MAT2A	Homo sapiens	P31153	Y2H Pooling	32814053
Intra	PELO	Q9BRX2	MAT2A	Homo sapiens	P31153	Y2H Array	32814053
Intra	PELO	Q9BRX2	KIF1B	Homo sapiens	O60333-2	Validated Y2H	32814053
Intra	PELO	Q9BRX2	KIF1B	Homo sapiens	O60333-2	Y2H Array	32814053
Intra	PELO	Q9BRX2	KIF1B	Homo sapiens	O60333-2	Y2H Pooling	32814053
Intra	PELO	Q9BRX2	LMO3	Homo sapiens	Q8TAP4-4	Y2H Array	32296183
Intra	PELO	Q9BRX2	LMO3	Homo sapiens	Q8TAP4-4	Y2H Prey Pooling	32296183
Intra	PELO	Q9BRX2	DYNLT1	Homo sapiens	P63172	Y2H Array	32296183
Intra	PELO	Q9BRX2	DYNLT1	Homo sapiens	P63172	Y2H Prey Pooling	32296183
Intra	PELO	Q9BRX2	PRKCA	Homo sapiens	P17252	Y2H Array	32814053
Intra	PELO	Q9BRX2	PRKCA	Homo sapiens	P17252	Validated Y2H	32814053
Intra	PELO	Q9BRX2	PRKCA	Homo sapiens	P17252	Y2H Pooling	32814053
Intra	PELO	Q9BRX2	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	PELO	Q9BRX2	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	PELO	Q9BRX2	SRPX	Homo sapiens	P78539	BiFC	20406461
Intra	PELO	Q9BRX2	SRPX	Homo sapiens	P78539	Y2H	20406461
Intra	PELO	Q9BRX2	SRPX	Homo sapiens	P78539	Pull Down	20406461
Intra	PELO	Q9BRX2	SRPX	Homo sapiens	P78539	Anti Tag CoIP	20406461
Intra	PELO	Q9BRX2	SRPX	Homo sapiens	P78539	Anti Bait CoIP	20406461
Intra	PELO	Q9BRX2	PPIA	Homo sapiens	P62937-2	Y2H Pooling	32814053
Intra	PELO	Q9BRX2	PPIA	Homo sapiens	P62937-2	Validated Y2H	32814053
Intra	PELO	Q9BRX2	PPIA	Homo sapiens	P62937-2	Y2H Array	32814053
Intra	PELO	Q9BRX2	HBS1L	Homo sapiens	Q9Y450	Y2H Array	32296183
Intra	PELO	Q9BRX2	HBS1L	Homo sapiens	Q9Y450	Y2H Array	31515488
Intra	PELO	Q9BRX2	HBS1L	Homo sapiens	Q9Y450	Y2H Prey Pooling	32296183
Intra	PELO	Q9BRX2	HBS1L	Homo sapiens	Q9Y450	Validated Y2H	32296183
Intra	PELO	Q9BRX2	HSPB1	Homo sapiens	P04792	Validated Y2H	32814053
Intra	PELO	Q9BRX2	HSPB1	Homo sapiens	P04792	Y2H Pooling	32814053
Intra	PELO	Q9BRX2	HSPB1	Homo sapiens	P04792	Y2H Array	32814053
Intra	PELO	Q9BRX2	HAX1	Homo sapiens	O00165	Anti Tag CoIP	20406461
Intra	PELO	Q9BRX2	HAX1	Homo sapiens	O00165	BiFC	20406461
Intra	PELO	Q9BRX2	HAX1	Homo sapiens	O00165	Pull Down	20406461
Intra	PELO	Q9BRX2	HAX1	Homo sapiens	O00165	Anti Bait CoIP	20406461
Intra	PELO	Q9BRX2	HAX1	Homo sapiens	O00165	Y2H	20406461
Intra	PELO	Q9BRX2	YWHAG	Homo sapiens	P61981	Validated Y2H	32814053
Intra	PELO	Q9BRX2	YWHAG	Homo sapiens	P61981	Y2H Array	32814053
Intra	PELO	Q9BRX2	YWHAG	Homo sapiens	P61981	Y2H Pooling	32814053
Intra	PELO	Q9BRX2	KAT5	Homo sapiens	Q92993	Validated Y2H	32814053
Intra	PELO	Q9BRX2	KAT5	Homo sapiens	Q92993	Y2H Array	32814053
Intra	PELO	Q9BRX2	KAT5	Homo sapiens	Q92993	Y2H Pooling	32814053
Intra	PELO	Q9BRX2	NEFL	Homo sapiens	P07196	Y2H Pooling	32814053
Intra	PELO	Q9BRX2	NEFL	Homo sapiens	P07196	Validated Y2H	32814053
Intra	PELO	Q9BRX2	NEFL	Homo sapiens	P07196	Y2H Array	32814053
Intra	PELO	Q9BRX2	WFS1	Homo sapiens	O76024	Y2H Array	32814053
Intra	PELO	Q9BRX2	WFS1	Homo sapiens	O76024	Validated Y2H	32814053
Intra	PELO	Q9BRX2	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053
Intra	PELO	Q9BRX2	BAG3	Homo sapiens	O95817	Validated Y2H	32814053
Intra	PELO	Q9BRX2	BAG3	Homo sapiens	O95817	Y2H Pooling	32814053
Intra	PELO	Q9BRX2	BAG3	Homo sapiens	O95817	Y2H Array	32814053
Intra	PELO	Q9BRX2	PRPS1	Homo sapiens	P60891	Validated Y2H	32814053
Intra	PELO	Q9BRX2	PRPS1	Homo sapiens	P60891	Y2H Pooling	32814053
Intra	PELO	Q9BRX2	PRPS1	Homo sapiens	P60891	Y2H Array	32814053
Intra	PELO	Q9BRX2	SETDB1	Homo sapiens	Q15047-2	Y2H Array	32814053
Intra	PELO	Q9BRX2	SETDB1	Homo sapiens	Q15047-2	Y2H Pooling	32814053
Intra	PELO	Q9BRX2	SETDB1	Homo sapiens	Q15047-2	Validated Y2H	32814053
Intra	PELO	Q9BRX2	FLNA	Homo sapiens	P21333-2	Y2H Prey Pooling	32296183
Intra	PELO	Q9BRX2	FLNA	Homo sapiens	P21333-2	Y2H Pooling	32814053
Intra	PELO	Q9BRX2	FLNA	Homo sapiens	P21333-2	Validated Y2H	32814053
Intra	PELO	Q9BRX2	FLNA	Homo sapiens	P21333-2	Y2H Array	32814053
Intra	PELO	Q9BRX2	FLNA	Homo sapiens	P21333-2	Y2H Array	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Progressive Myoclonus Epilepsy 10

Early-Onset Lafora Body Disease

Epm10

Sveinsson Chorioretinal Atrophy

SCRA	Atrophia Areata
Helicoid Peripapillary Chorioretinal Degeneration	Hpcd
Aa	Peripapillary Chorioretinal Degeneration, Icelandic Type
Helicoidal Peripapillary Chorioretinal Degeneration	Atrophy, Chorioretinal, Sveinsson

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS10323	PELO Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	PELO	MGD	MGI:2145154
Rattus norvegicus	PELO	RGD	RGD:1359591
Bos taurus	PELO	VGNC	VGNC:32743
Felis catus	PELO	VGNC	VGNC:102287
Macaca mulatta	PELO	VGNC	VGNC:84478

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。	站点地图隐私声明
沪ICP备15051369号-4 上海工商沪公网安备31011502019417 沪(浦)应急管危经许[2021]201709(QFYS) 营业执照（三证合一）
Copyright © 2013-2024 MedChemExpress. All Rights Reserved.

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

PELO - pelota mRNA surveillance and ribosome rescue factor Gene

关于 PELO

功能概要

PELO 基因产物(1)

PELO 蛋白结构

PELO 蛋白互作信息

关联疾病

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

姓名
邮箱 *

Sorry, but the email address you supplied was invalid.

PELO - pelota mRNA surveillance and ribosome rescue factor Gene

关于 PELO

功能概要

PELO 基因产物(1)

PELO 蛋白结构

PELO 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z