1. Gene
  2. PRKCA - protein kinase C alpha Gene

PRKCA - protein kinase C alpha Gene

中文名称:蛋白激酶 C α

种属: Homo sapiens

同用名: AAG6; PKCA; PRKACA; PKCI+/-; PKCalpha; PKC-alpha

基因 ID: 5578 | 基因类型: protein coding

关于 PRKCA

Cytogenetic location: 17q24.2 Genomic coordinates (GRCh38): 17:66,302,613-66,810,743 (from NCBI)

This gene has 5 transcripts (splice variants), 284 orthologues and 9 paralogues. Ubiquitous expression in brain (RPKM 12.7), adrenal (RPKM 6.5) and 22 other tissues.

功能概要

蛋白激酶 C (PKC) 是一个丝氨酸和苏氨酸特异性蛋白激酶家族,可被钙和第二信使甘油二酯激活。 PKC 家族成员磷酸化多种蛋白质靶标,并且已知参与多种细胞信号通路。 PKC 家族成员还充当佛波酯 (一类肿瘤促进剂) 的主要受体。 PKC 家族的每个成员都有特定的表达谱,并被认为在细胞中发挥着独特的作用。该基因编码的蛋白质是 PKC 家族成员之一。据报道,这种激酶在许多不同的细胞过程中发挥作用,例如细胞粘附、细胞转化、细胞周期检查点和细胞体积控制。小鼠基因敲除研究表明,这种激酶可能是心肌细胞中心肌收缩力和 CA (2+) 处理的基本调节因子。[RefSeq 提供,2008 年 7 月]

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been reported to play roles in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control. Knockout studies in mice suggest that this kinase may be a fundamental regulator of cardiac contractility and CA(2+) handling in myocytes. [provided by RefSeq, Jul 2008]

PRKCA 基因产物(11)

mRNA Protein Name
XR_001752558.2
XM_047436389.1 XP_047292345.1 protein kinase C alpha type isoform X5
XM_017024836.3 XP_016880325.1 protein kinase C alpha type isoform X1
XR_007065317.1
XM_017024837.2 XP_016880326.1 protein kinase C alpha type isoform X2
XM_047436388.1 XP_047292344.1 protein kinase C alpha type isoform X4
XR_007065315.1
XM_024450829.2 XP_024306597.1 protein kinase C alpha type isoform X3
XM_024450830.2 XP_024306598.1 protein kinase C alpha type isoform X3
NM_002737.3 NP_002728.2 protein kinase C alpha type
XR_007065316.1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables calcium,diacylglycerol-dependent serine/threonine kinase activity IDA
IDA: 通过直接分析推断
25313067 GOA
enables calcium,diacylglycerol-dependent serine/threonine kinase activity IMP
IMP: 通过突变表型推断
33934390 GOA
enables diacylglycerol-dependent serine/threonine kinase activity EXP
EXP: 通过实验结果推断
7520444 GOA
enables enzyme binding IDA
IDA: 通过直接分析推断
18556656 GOA
enables histone H3T6 kinase activity IDA
IDA: 通过直接分析推断
20228790 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
12571249 GOA
enables protein kinase activity IDA
IDA: 通过直接分析推断
10770950 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in desmosome assembly IMP
IMP: 通过突变表型推断
18474624 GOA
involved in negative regulation of glial cell apoptotic process IMP
IMP: 通过突变表型推断
9927633 GOA
involved in positive regulation of angiogenesis IMP
IMP: 通过突变表型推断
11909826 GOA
involved in positive regulation of angiotensin-activated signaling pathway IDA
IDA: 通过直接分析推断
25313067 GOA
involved in positive regulation of blood vessel endothelial cell migration IDA
IDA: 通过直接分析推断
20011604 GOA
involved in positive regulation of cell adhesion IMP
IMP: 通过突变表型推断
11909826 GOA
involved in positive regulation of cell migration IMP
IMP: 通过突变表型推断
23990668 GOA
involved in positive regulation of endothelial cell migration IMP
IMP: 通过突变表型推断
11909826 GOA
involved in positive regulation of endothelial cell proliferation IMP
IMP: 通过突变表型推断
11909826 GOA
involved in positive regulation of lipopolysaccharide-mediated signaling pathway IMP
IMP: 通过突变表型推断
9830023 GOA
involved in positive regulation of mitotic cell cycle IMP
IMP: 通过突变表型推断
10848585 GOA
involved in post-translational protein modification IDA
IDA: 通过直接分析推断
20228790 GOA
involved in protein phosphorylation IDA
IDA: 通过直接分析推断
10770950 GOA
involved in regulation of platelet aggregation IDA
IDA: 通过直接分析推断
12724315 GOA
involved in response to interleukin-1 IMP
IMP: 通过突变表型推断
19281832 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in ciliary basal body IDA
IDA: 通过直接分析推断
33934390 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
15632189 GOA
located in cytosol IDA
IDA: 通过直接分析推断
17983652 GOA
located in endoplasmic reticulum IDA
IDA: 通过直接分析推断
18556656 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
15632189 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

PRKCA 蛋白结构

C1_1

C1_1: Phorbol esters/diacylglycerol binding domain (C1 domain) (37 - 87)

C1_1

C1_1: Phorbol esters/diacylglycerol binding domain (C1 domain) (102 - 153)

C2

C2: C2 domain (173 - 259)

Pkinase

Pkinase: Protein kinase domain (340 - 583)

Pkinase_C

Pkinase_C: Protein kinase C terminal domain (624 - 662)

  • 0
  • 200
  • 400
  • 600
  • 672 a.a.
蛋白主名 其他名称

protein kinase C alpha type

PKC-A

aging-associated gene 6

PRKCA 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra PRKCA P17252 HOXB13 Homo sapiens Q92826
Y2H Array
32814053
Intra PRKCA P17252 HOXB13 Homo sapiens Q92826
Y2H Pooling
32814053
Intra PRKCA P17252 HOXB13 Homo sapiens Q92826
Validated Y2H
32814053
Intra PRKCA P17252 SYNGR3 Homo sapiens O43761
Y2H Array
32814053
Intra PRKCA P17252 SYNGR3 Homo sapiens O43761
Validated Y2H
32814053
Intra PRKCA P17252 SYNGR3 Homo sapiens O43761
Y2H Pooling
32814053
Intra PRKCA P17252 BANP Homo sapiens Q8N9N5-2
Validated Y2H
32814053
Intra PRKCA P17252 BANP Homo sapiens Q8N9N5-2
Y2H Array
32814053
Intra PRKCA P17252 BANP Homo sapiens Q8N9N5-2
Y2H Pooling
32814053
Intra PRKCA P17252 IFT43 Homo sapiens Q96FT9-2
Validated Y2H
32814053
Intra PRKCA P17252 IFT43 Homo sapiens Q96FT9-2
Y2H Pooling
32814053
Intra PRKCA P17252 IFT43 Homo sapiens Q96FT9-2
Y2H Array
32814053
Intra PRKCA P17252 ZNF444 Homo sapiens Q8N0Y2-2
Y2H Array
32814053
Intra PRKCA P17252 ZNF444 Homo sapiens Q8N0Y2-2
Validated Y2H
32814053
Intra PRKCA P17252 ZNF444 Homo sapiens Q8N0Y2-2
Y2H Pooling
32814053
Intra PRKCA P17252 WWOX Homo sapiens Q9NZC7-5
Validated Y2H
32814053
Intra PRKCA P17252 WWOX Homo sapiens Q9NZC7-5
Y2H Array
32814053
Intra PRKCA P17252 WWOX Homo sapiens Q9NZC7-5
Y2H Pooling
32814053
Intra PRKCA P17252 SDHC Homo sapiens Q99643
Y2H Array
32814053
Intra PRKCA P17252 SDHC Homo sapiens Q99643
Validated Y2H
32814053
Intra PRKCA P17252 SDHC Homo sapiens Q99643
Y2H Pooling
32814053
Intra PRKCA P17252 FRMD6 Homo sapiens Q96NE9-2
Y2H Array
32814053
Intra PRKCA P17252 FRMD6 Homo sapiens Q96NE9-2
Y2H Pooling
32814053
Intra PRKCA P17252 FRMD6 Homo sapiens Q96NE9-2
Validated Y2H
32814053
Intra PRKCA P17252 MED19 Homo sapiens A0JLT2-2
Validated Y2H
32814053
Intra PRKCA P17252 MED19 Homo sapiens A0JLT2-2
Y2H Array
32814053
Intra PRKCA P17252 MED19 Homo sapiens A0JLT2-2
Y2H Pooling
32814053
Intra PRKCA P17252 IL3RA Homo sapiens P26951
Y2H Pooling
32814053
Intra PRKCA P17252 IL3RA Homo sapiens P26951
Y2H Array
32814053
Intra PRKCA P17252 IL3RA Homo sapiens P26951
Validated Y2H
32814053
Intra PRKCA P17252 FSCN2 Homo sapiens O14926
Y2H Array
32814053
Intra PRKCA P17252 FSCN2 Homo sapiens O14926
Validated Y2H
32814053
Intra PRKCA P17252 FSCN2 Homo sapiens O14926
Y2H Pooling
32814053
Intra PRKCA P17252 CPN1 Homo sapiens P15169
Validated Y2H
32814053
Intra PRKCA P17252 CPN1 Homo sapiens P15169
Y2H Array
32814053
Intra PRKCA P17252 VNN2 Homo sapiens O95498
Y2H Pooling
32814053
Intra PRKCA P17252 VNN2 Homo sapiens O95498
Validated Y2H
32814053
Intra PRKCA P17252 VNN2 Homo sapiens O95498
Y2H Array
32814053
Intra PRKCA P17252 ZNF248 Homo sapiens Q05CR2
Validated Y2H
32814053
Intra PRKCA P17252 ZNF248 Homo sapiens Q05CR2
Y2H Array
32814053
Intra PRKCA P17252 ZNF248 Homo sapiens Q05CR2
Y2H Pooling
32814053
Intra PRKCA P17252 SP2 Homo sapiens Q9BRW5
Validated Y2H
32814053
Intra PRKCA P17252 SP2 Homo sapiens Q9BRW5
Y2H Array
32814053
Intra PRKCA P17252 SP2 Homo sapiens Q9BRW5
Y2H Pooling
32814053
Intra PRKCA P17252 RMND1 Homo sapiens Q9NWS8-3
Validated Y2H
32814053
Intra PRKCA P17252 RMND1 Homo sapiens Q9NWS8-3
Y2H Array
32814053
Intra PRKCA P17252 RMND1 Homo sapiens Q9NWS8-3
Y2H Pooling
32814053
Intra PRKCA P17252 BAGE Homo sapiens Q13072
Validated Y2H
32814053
Intra PRKCA P17252 BAGE Homo sapiens Q13072
Y2H Pooling
32814053
Intra PRKCA P17252 BAGE Homo sapiens Q13072
Y2H Array
32814053
Intra PRKCA P17252 GPR160 Homo sapiens Q9UJ42
Y2H Pooling
32814053
Intra PRKCA P17252 GPR160 Homo sapiens Q9UJ42
Validated Y2H
32814053
Intra PRKCA P17252 GPR160 Homo sapiens Q9UJ42
Y2H Array
32814053
Intra PRKCA P17252 ZFYVE21 Homo sapiens Q9BQ24
Y2H Array
32814053
Intra PRKCA P17252 ZFYVE21 Homo sapiens Q9BQ24
Validated Y2H
32814053
Intra PRKCA P17252 ZFYVE21 Homo sapiens Q9BQ24
Y2H Pooling
32814053
Intra PRKCA P17252 EGFR Homo sapiens P00533
Lumier
24658140
Intra PRKCA P17252 MAPK11 Homo sapiens Q15759
Y2H Pooling
32814053
Intra PRKCA P17252 MAPK11 Homo sapiens Q15759
Validated Y2H
32814053
Intra PRKCA P17252 MAPK11 Homo sapiens Q15759
Y2H Array
32814053
Intra PRKCA P17252 H4C16 Homo sapiens P62805
Y2H Pooling
32814053
Intra PRKCA P17252 H4C16 Homo sapiens P62805
Validated Y2H
32814053
Intra PRKCA P17252 H4C16 Homo sapiens P62805
Y2H Array
32814053
Intra PRKCA P17252 EIF3E Homo sapiens P60228
Validated Y2H
32814053
Intra PRKCA P17252 EIF3E Homo sapiens P60228
Y2H Pooling
32814053
Intra PRKCA P17252 EIF3E Homo sapiens P60228
Y2H Array
32814053
Intra PRKCA P17252 RPL35A Homo sapiens P18077
Validated Y2H
32814053
Intra PRKCA P17252 RPL35A Homo sapiens P18077
Y2H Array
32814053
Intra PRKCA P17252 RPL35A Homo sapiens P18077
Y2H Pooling
32814053
Intra PRKCA P17252 SDC4 Homo sapiens P31431
Pull Down
12571249
Intra PRKCA P17252 MAP3K9 Homo sapiens P80192
Y2H Pooling
32814053
Intra PRKCA P17252 MAP3K9 Homo sapiens P80192
Validated Y2H
32814053
Intra PRKCA P17252 MAP3K9 Homo sapiens P80192
Y2H Array
32814053
Intra PRKCA P17252 MAGEH1 Homo sapiens Q9H213
Validated Y2H
32814053
Intra PRKCA P17252 MAGEH1 Homo sapiens Q9H213
Y2H Pooling
32814053
Intra PRKCA P17252 MAGEH1 Homo sapiens Q9H213
Y2H Array
32814053
Intra PRKCA P17252 ARL6IP4 Homo sapiens Q66PJ3-4
Validated Y2H
32814053
Intra PRKCA P17252 ARL6IP4 Homo sapiens Q66PJ3-4
Y2H Array
32814053
Intra PRKCA P17252 ARL6IP4 Homo sapiens Q66PJ3-4
Y2H Pooling
32814053
Intra PRKCA P17252 TCF4 Homo sapiens P15884
Y2H Pooling
32814053
Intra PRKCA P17252 TCF4 Homo sapiens P15884
Validated Y2H
32814053
Intra PRKCA P17252 TCF4 Homo sapiens P15884
Y2H Array
32814053
Intra PRKCA P17252 DRD1 Homo sapiens P21728
Y2H Array
32814053
Intra PRKCA P17252 DRD1 Homo sapiens P21728
Y2H Pooling
32814053
Intra PRKCA P17252 DRD1 Homo sapiens P21728
Validated Y2H
32814053
Intra PRKCA P17252 PRKCE Homo sapiens Q02156
Anti Tag CoIP
31980649
Intra PRKCA P17252 IGFBP3 Homo sapiens P17936
Y2H Pooling
32814053
Intra PRKCA P17252 IGFBP3 Homo sapiens P17936
Validated Y2H
32814053
Intra PRKCA P17252 IGFBP3 Homo sapiens P17936
Y2H Array
32814053
Intra PRKCA P17252 CCDC47 Homo sapiens Q96A33
Validated Y2H
32814053
Intra PRKCA P17252 CCDC47 Homo sapiens Q96A33
Y2H Array
32814053
Intra PRKCA P17252 CCDC47 Homo sapiens Q96A33
Y2H Pooling
32814053
Intra PRKCA P17252 DEXI Homo sapiens O95424
Validated Y2H
32814053
Intra PRKCA P17252 DEXI Homo sapiens O95424
Y2H Array
32814053
Intra PRKCA P17252 DEXI Homo sapiens O95424
Y2H Pooling
32814053
Intra PRKCA P17252 LIPT1 Homo sapiens Q9Y234
Validated Y2H
32814053
Intra PRKCA P17252 LIPT1 Homo sapiens Q9Y234
Y2H Array
32814053
Intra PRKCA P17252 LIPT1 Homo sapiens Q9Y234
Y2H Pooling
32814053
Intra PRKCA P17252 NDUFV1 Homo sapiens P49821
Y2H Array
32814053
Intra PRKCA P17252 NDUFV1 Homo sapiens P49821
Y2H Pooling
32814053
Intra PRKCA P17252 NDUFV1 Homo sapiens P49821
Validated Y2H
32814053
Intra PRKCA P17252 DNPH1 Homo sapiens O43598
Validated Y2H
32814053
Intra PRKCA P17252 DNPH1 Homo sapiens O43598
Y2H Array
32814053
Intra PRKCA P17252 DNPH1 Homo sapiens O43598
Y2H Pooling
32814053
Intra PRKCA P17252 ZSCAN9 Homo sapiens O15535
Validated Y2H
32814053
Intra PRKCA P17252 ZSCAN9 Homo sapiens O15535
Y2H Array
32814053
Intra PRKCA P17252 ZSCAN9 Homo sapiens O15535
Y2H Pooling
32814053
Intra PRKCA P17252 ACAP1 Homo sapiens Q15027
Validated Y2H
32814053
Intra PRKCA P17252 ACAP1 Homo sapiens Q15027
Y2H Pooling
32814053
Intra PRKCA P17252 ACAP1 Homo sapiens Q15027
Y2H Array
32814053
Intra PRKCA P17252 SNCA Homo sapiens P37840
Y2H Pooling
32814053
Intra PRKCA P17252 SNCA Homo sapiens P37840
Validated Y2H
32814053
Intra PRKCA P17252 SNCA Homo sapiens P37840
Y2H Array
32814053
Intra PRKCA P17252 OXA1L Homo sapiens Q2M1J6
Validated Y2H
32814053
Intra PRKCA P17252 OXA1L Homo sapiens Q2M1J6
Y2H Array
32814053
Intra PRKCA P17252 OXA1L Homo sapiens Q2M1J6
Y2H Pooling
32814053
Intra PRKCA P17252 KRTAP3-1 Homo sapiens Q9BYR8
Y2H Array
32814053
Intra PRKCA P17252 KRTAP3-1 Homo sapiens Q9BYR8
Y2H Pooling
32814053
Intra PRKCA P17252 KRTAP3-1 Homo sapiens Q9BYR8
Validated Y2H
32814053
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon

Hepatocellular Carcinoma

Liver Cancer

Primary Liver Cancer

HCC

Hepatoma

Malignant Neoplasm Of Liver

Liver Neoplasms

Cancer, Hepatocellular

Liver Cell Carcinoma

Lcc

Hepatoblastoma, Somatic

Hepatic Cancer

Primary Malignant Neoplasm Of Liver

Rare Tumor Of Liver And Intrahepatic Biliary Tract

Hepatocellular Carcinoma, Somatic

Hepatocellular Carcinoma, Childhood Type, Somatic

Hepatocellular Cancer, Somatic

Ca Liver - Primary

Hepatic Neoplasm

Malignant Hepato-Biliary Neoplasm

Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

Malignant Neoplasm Of Liver, Primary

Malignant Tumor Of Liver

Neoplasm Of Liver

Non-Resectable Primary Hepatic Malignant Neoplasm

Resectable Malignant Neoplasm Of Liver

Resectable Malignant Neoplasm Of The Liver

Primary Liver Carcinoma

Primary Malignant Liver Neoplasm

Primary Cancer Of Liver

Primary Tumor Of The Liver

Rare Tumor Of Liver And Ibt

Hepatocellular Cancer

Neoplasm Of The Liver

Hepatomas

Liver Neoplasm

Liver Carcinoma

Liver And Intrahepatic Biliary Tract Carcinoma

Malignant Hepatobiliary Neoplasm

Adult Primary Hepatocellular Carcinoma

Hepatoblastoma

Carcinoma Of Liver

Malignant Liver Tumour

Malignant Hepatic Tumour

Melanoma

Malignant Melanoma

Cutaneous Melanoma

Naevocarcinoma

Malignant Melanomas

Basal Cell Carcinoma

Basal Cell Cancer

Basal Cell Neoplasm

Basal Cell Carcinoma Of Skin

Malignant Basal Cell Tumor

Basal Cell Tumor

Epithelioma Basal Cell

Malignant Basal Cell Neoplasm

Rodent Ulcer

Carcinoma Basal Cell

Neoplasms, Basal Cell

Basal Cell Carcinomas

Experimental Organism Basal Cell Carcinoma

Nodulo-Ulcerative Basal Cell Carcinoma

Basalioma

Basal Cell Epithelioma Of Skin

Bcc - [Basal Cell Carcinoma] Of Skin

Rodent Ulcer Of Skin

Rodent Ulcer Of Unspecified Site

Basal Cell Epithelioma Of Unspecified Site

Thymoma

Primary Thymic Epithelial Neoplasm

Primary Thymic Epithelial Tumor

Thymus Neoplasms

Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Protection Against

Lung Cancer, Susceptibility To

Adenocarcinoma Of Lung, Somatic

Nonsmall Cell Lung Cancer

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma

Breast Cancer

Breast Carcinoma

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Male Breast Cancer

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation

Multiple Sclerosis

MS

Multiple Sclerosis, Susceptibility To

Disseminated Sclerosis

Multiple Sclerosis, Disease Progression, Modifier Of

Insular Sclerosis

Multiple Sclerosis Modifier Of Disease Progression

Multiple Sclerosis, Susceptibility To 1

Multiple Sclerosis, Susceptibility To, 1

Multiple Sclerosis 1

Generalized Multiple Sclerosis

Multiple Sclerosis Variant

Multiple Sclerosis Susceptibility To

Cerebrospinal Sclerosis

Generalised Multiple Sclerosis

Ms - [Multiple Sclerosis]

Disseminated Cerebrospinal Sclerosis

Disseminated Multiple Sclerosis

Disseminated Nervous System Myelosclerosis

Multiple Cerebrospinal Sclerosis

Multiple Combined Sclerosis

Multiple Sclerosis Generalised

Disseminated Brain Sclerosis

Disseminated Spinal Sclerosis

Insular Brain Sclerosis

Miliary Brain Sclerosis

Multiple Combined Sclerosis Of Spinal Cord

Multiple Ascending Sclerosis

Multiple Brain Sclerosis

Multiple Sclerosis Of Brain Stem

Multiple Sclerosis Of The Brain Stem

Multiple Sclerosis Of Cord

Sclérose En Plaques

Plaque Sclerosis

Multiple Sclerosis Of The Spinal Cord

Asbestos-Related Lung Carcinoma
Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer

Nervous System Disease

Abnormality Of The Nervous System

Nervous System Diseases

Nervous System Disorder

Alzheimer Disease, Familial, 1

Alzheimer Disease

Alzheimer'S Disease

Presenile And Senile Dementia

AD1

Alzheimer Disease, Susceptibility To

Alzheimer Disease, Late-Onset, Susceptibility To

Alzheimer Disease 1, Familial

AD

Familial Alzheimer Disease

Alzheimer Disease, Late-Onset

Alzheimers Dementia

Alzheimer Dementia

Alzheimer Sclerosis

Alzheimer Syndrome

Alzheimer-Type Dementia

Dat

Primary Senile Degenerative Dementia

Sdat

Alzheimer Disease 1

Autosomal Dominant Alzheimer Disease

Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy

Late Onset Alzheimer Disease

Alzheimers Disease

Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy

Late-Onset Alzheimers Disease

Alzheimer'S Disease Pathway Kegg

Dementia Due To Alzheimer'S Disease

Alzheimer Disease Type 1

Alzheimers

Ovarian Cancer

Ovarian Carcinoma

Ovarian Neoplasm

Malignant Tumour Of Ovary

Epithelial Ovarian Cancer

Neoplasm Of Ovary

Ovarian Neoplasms

Ovarian Cancers

Malignant Neoplasm Of Ovary

Primary Malignant Neoplasm Of Ovary

Ovarian Cancer, Somatic

Malignant Ovarian Tumor

Ovary Neoplasm

Primary Ovarian Cancer

Tumor Of The Ovary

Cancer Of The Ovary

Malignant Neoplasm Of The Ovary

Malignant Tumor Of The Ovary

Ovarian Malignant Tumor

OC

Ovarian Carcinomas

Cancer, Ovarian

Cancer Of Ovary

Ovary Cancer

Ca Ovary

Dilated Cardiomyopathy

Familial Dilated Cardiomyopathy

Primary Dilated Cardiomyopathy

Idiopathic Dilated Cardiomyopathy

Congestive Cardiomyopathy

Idiopathic Dilation Cardiomyopathy

Primary Familial Dilated Cardiomyopathy

Cardiomyopathy, Dilated

DCM

Cardiomyopathy, Familial Dilated

Dilated Cardiomyopathy, Familial

Hypokinetic Dilated Cardiomyopathy, Familial

Familial Idiopathic Cardiomyopathy

Fdc

Cardiomyopathy, Familial Idiopathic

Idiopathic Cardiomegaly

Dilated Congestive Cardiomyopathy

Chronic Dilated Cardiomyopathy

Ccm - [Congestive Cardiomyopathy]

Cocm - [Congestive Cardiomyopathy]

Dcm - [Dilated Cardiomyopathy]

Dilated-Hypokinetic Cardiomyopathy

Congestive Idiopathic Cardiomyopathy

Primary Idiopathic Dilated Cardiomyopathy

Type 2 Diabetes Mellitus

Insulin Resistance

NIDDM

Diabetes Mellitus, Non-Insulin-Dependent

Type 2 Diabetes

T2D

Noninsulin-Dependent Diabetes Mellitus

Diabetes Mellitus, Type Ii

Maturity-Onset Diabetes

Insulin Resistance, Severe, Digenic

Diabetes Mellitus, Type 2

Diabetes Mellitus, Noninsulin-Dependent

Diabetes Mellitus, Noninsulin-Dependent, Association With

Diabetes Mellitus, Noninsulin-Dependent, Late Onset

Hypertension, Insulin Resistance-Related, Susceptibility To

Insulin Resistance, Susceptibility To

Non-Insulin-Dependent Diabetes Mellitus

Type Ii Diabetes Mellitus

Adult-Onset Diabetes Mellitus

Maturity-Onset Diabetes Mellitus

Diabetes Mellitus Type 2

Type Ii Diabetes

Type 2 Diabetes Mellitus, Susceptibility To

Diabetes, Type 2

Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To

Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To

Diabetes Mellitus, Type 2, Susceptibility To

Diabetes Mellitus, Noninsulin-Dependent, 2

Diabetes Mellitus, Type Ii, Susceptibility To

Hypertension, Insulin Resistance-Related

Adult-Onset Diabetes

Aodm

Diabetes Mellitus, Adult-Onset

Diabetes Mellitus Type Ii

Diabetes Mellitus Type 2, Susceptibility To

Diabetes, Type Ii, Susceptibility To

Diabetes Type 2

Diabetes Mellitus

Adult Onset Diabetes

Maturity Onset Diabetes

Nonketotic Diabetes

Non-Insulin Dependent Diabetes Mellitus

T2dm - [Type 2 Diabetes Mellitus]

Niddm - [Non Insulin Dependent Diabetes Mellitus]

Dm2

Dm Type Ii

Diabetic Type 2

Insulin Requiring Type 2 Diabetes

Noninsulin Dependent Diabetes

Non-Insulin-Dependent Diabetes Mellitus Without Complications

Diabetes Due To Insulin Secretory Defect

Diabetes Mellitus Due To Insulin Secretory Defect

Non-Insulin-Dependent Diabetes Of The Young

Senile Diabetes

Nonketotic Hyperglycaemia

Stable Diabetes

Endometrial Cancer

Endometrial Carcinoma

Endometrial Neoplasm

Malignant Neoplasm Of Endometrium

Endometrioid Carcinoma

Endometrial Neoplasms

Carcinoma, Endometrioid

Endometrial Cancer, Familial

Endometrial Carcinoma, Somatic

Endometrial Cancer, Susceptibility To

Endometrial Ca

Malignant Endometrial Neoplasm

Neoplasm Of Endometrium

Primary Malignant Neoplasm Of Endometrium

Tumor Of Endometrium

Carcinoma Of The Endometrium

Endometrioid Carcinoma Of Female Reproductive System

ENDMC

Carcinoma Endometrioid

Endometrial Cancers

Cancer, Endometrial

Uterine Corpus Cancer

Cystic Fibrosis

Mucoviscidosis

CF

Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis

Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis

Cystic Fibrosis Lung Disease, Modifier Of

Cystic Fibrosis Of Pancreas

Fibrocystic Disease Of Pancreas

Cf - [Cystic Fibrosis]

Cystic Fibrosis Nos

Fibrocystic Disease

Fibrocystic Disease Of The Pancreas

Mucoviscidosis Of Pancreas

Nonproliferative Fibrocystic Disease

Pancreatic Cystic Fibrosis

Congenital Stationary Night Blindness

Night Blindness, Congenital Stationary

Congenital Essential Nyctalopia

Oguchi Disease

Blindness, Night, Stationary, Congenital

Neural Tube Defects

Spina Bifida

Neural Tube Defect

NTD

Neural Tube Defects, Susceptibility To

Spinal Dysraphism

Spina Bifida, Susceptibility To

Rachischisis

Cleft Spine

Open Spine

Hydrocele Spinalis

Neural Tube Defect Nos

Sb - [Spina Bifida]

Spinal Hernia Nos

Spinal Fissure Nos

Asthma

Chronic Obstructive Asthma

Asthma, Diminished Response To Antileukotriene Treatment In

Bronchial Hyperreactivity

Asthma, Susceptibility To

Asthma, Bronchial

Asthma, Protection Against

Asthma, Nocturnal, Susceptibility To

Nocturnal Asthma

Asthma-Related Traits

Asthma-Related Traits, Susceptibility To

Asthma, Nocturnal

Chronic Obstructive Asthma With Acute Exacerbation

Chronic Obstructive Asthma With Status Asthmaticus

Exercise Induced Asthma

Exercise-Induced Asthma

Bronchial Asthma

Asthma, Exercise-Induced

Idiosyncratic Asthma

Unspecified Asthma With Acute Exacerbation

Asthma, Unspecified, With Stated Status Asthmaticus

Status Asthmaticus Nos

Acute Severe Asthma

Acute Severe Bronchial Asthma

Status Asthma

Status Post Asthmaticus

Hyperglycemia
Leber Plus Disease

Leber Congenital Amaurosis

Lca

Leber'S Amaurosis

Leber'S Disease

Amaurosis Congenita Of Leber

Amaurosis Congenita Of Leber, Type 1

Lhon Plus Disease

Congenital Absence Of The Rods And Cones

Congenital Retinal Blindness

Crb

Congenital Amaurosis Of Retinal Origin

Leber'S Congenital Amaurosis

Leber Congenital Amaurosis 1

Leber'S Congenital Tapetoretinal Degeneration

Leber'S Congenital Tapetoretinal Dysplasia

Lca1

Leber Congenital Amaurosis Type 1

Retinal Blindness, Congenital

Amaurosis, Leber Congenital

Dysgenesis Neuroepithelialis Retinae

Hereditary Epithelial Dysplasia Of Retina

Hereditary Retinal Aplasia

Heredoretinopathia Congenitalis

Leber Abiotrophy

Leber Congenital Tapetoretinal Degeneration

Lebers Congenital Amaurosis

Optic Atrophy, Hereditary, Leber

Pancreatic Cancer

Pancreatic Carcinoma

Familial Pancreatic Carcinoma

Pancreatic Neoplasm

Carcinoma Of Pancreas

Pancreatic Carcinoma, Familial

Malignant Neoplasm Of Pancreas

Pancreatic Acinar Carcinoma

Pancreatic Tumor

Familial Pancreatic Cancer

Neoplasm Of The Pancreas

Pancreatic Carcinoma, Somatic

Pancreatic Cancer, Somatic

Ca Body Of Pancreas

Ca Head Of Pancreas

Ca Tail Of Pancreas

Malignant Neoplasm Of Body Of Pancreas

Malignant Neoplasm Of Head Of Pancreas

Malignant Neoplasm Of Tail Of Pancreas

Pancreas Neoplasm

Exocrine Cancer

Exocrine Pancreas Carcinoma

Hereditary Pancreatic Cancer

Hereditary Pancreatic Carcinoma

PNCA

Cancer Of The Pancreas

Pancreatic Cancer, Susceptibility To

Carcinoma Of Head Of Pancreas

Pancreatic Neoplasms

Pancreatic Tumors

Cancer, Pancreatic

Cancer Of Pancreas

Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site

Glioblastoma

Glioblastoma Multiforme

Gbm

Adult Glioblastoma Multiforme

Grade Iv Adult Astrocytic Tumor

Primary Glioblastoma Multiforme

Spongioblastoma Multiforme

Adult Glioblastoma

Primary Glioblastoma

Retinitis Pigmentosa

RP

Rod-Cone Dystrophy

Autosomal Recessive Retinitis Pigmentosa

Non-Syndromic Retinitis Pigmentosa

Pericentral Pigmentary Retinopathy

Pigmentary Retinopathy

Tapetoretinal Degeneration

Rcd

Retinitis Pigmentosa Autosomal Recessive

ARRP

Retinitis Pigmentosa, Autosomal Recessive

Retinitis Pigmentosa 1

Skin Disease

Skin Diseases

Abnormality Of The Skin

Skin Diseases, Genetic

Genodermatosis

Skin And Subcutaneous Tissue Disease

Dermatologic Disorders

Chordoid Glioma

Chordoid Glioma Of The Third Ventricle

Neuroblastoma

Nb

Neuroblastoma, Susceptibility To

Neuroblastomas

Central Neuroblastoma

Cone-Rod Dystrophy 2

Cone-Rod Dystrophy

CORD2

Cone-Rod Retinal Dystrophy

Rcrd2

Cone-Rod Retinal Dystrophy 2

Crd2

Cord

Crd

Retinal Cone-Rod Dystrophy

Cone-Rod Retinal Dystrophy-2

Retinal Cone-Rod Dystrophy 2

Tapetoretinal Degeneration

Cone-Rod Degeneration

Cone Rod Dystrophy

Dystrophy, Cone-Rod

Dystrophy, Cone-Rod, Type 2

Retinitis Pigmentosa

Retinitis Pigmentosa 2

Progressive Cone-Rod Dystrophy

Hypertension, Essential

Essential Hypertension

Hypertension

High Blood Pressure

Hypertension, Essential, Susceptibility To

Hypertensive Disease

Primary Hypertension

EHT

Hypertension, Salt-Sensitive Essential, Susceptibility To

Hyperpiesia

Idiopathic Hypertension

Hypertensive Disorder

Hypertension, Essential, Susceptibility To, 3

Hypertension, Essential 3

Hypertension, Essential, Salt-Sensitive

Hypertension, Essential, Susceptibility To, 6

Hypertension, Essential 6

Hypertension, Salt-Sensitive Essential

Hypertension, Susceptibility To

Hypertension, Essential, Susceptibility To, 4

Hypertension, Essential 4

Hypertension, Essential, Susceptibility To, 2

Hypertension, Essential 2

Hypertension, Essential, Susceptibility To, 1

Hypertension, Essential 1

Hypertension, Essential, Susceptibility To, 5

Hypertension, Essential 5

Htn

Vascular Hypertensive Disorder

Systemic Primary Arterial Hypertension

Hbp - [High Blood Pressure]

Systemic Arterial Hypertensive Disorder

Elevated Blood Pressure

Arterial Hypertension Nos

Hypertension Nos

Benign Hypertension

Systemic Arterial Hypertension

Systemic Hypertension

Artery Htn

Benign Htn

Vascular Htn

Vascular Hypertension

Cholesterol Hypertension

Cholesterol Htn

Idiopathic Htn

Malignant Hypertension

Malignant Htn

Raised Blood Pressure

Cardiovascular Hypertension

Primary Htn - [Hypertension]

High Arterial Tension

High Blood Pressure Disorder

Ht - [Hypertension]

Htn - [Hypertension]

Hypertensive Vascular Disease

Hypertensive Vascular Degeneration

Heart Disease

Heart Failure

Congenital Heart Disease

Heart Diseases

Congenital Heart Defects

Congenital Heart Defect

Congenital Anomaly Of Heart

Heart Defect

Heart Malformation

Heart-Congenital Defect

Congenital Heart Disorder

Heart Defects Congenital

Heart Defects, Congenital

Heart Defects

Heart Disease, Congenital

Disease, Heart, Congenital

Congestive Heart Failure

Glioma
Eye Disease

Eye Diseases

Abnormality Of The Eye

Toxoplasma Oculopathy

Rhabdomyosarcoma
Cryptosporidiosis

Cryptosporidial Gastroenteritis

Intestinal Cryptosporidiosis

Infection By Cryptosporidium

Gastroenteritis Due To Cryptosporidium

Cryptosporidial Infection

Fundus Dystrophy

Retinal Dystrophy

Retinal Dystrophies

Dystrophy, Retinal

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus PRKCA MGD MGI:97595
Macaca mulatta PRKCA VGNC VGNC:76409
Bos taurus PRKCA VGNC VGNC:33327
Felis catus PRKCA VGNC VGNC:69055
Rattus norvegicus PRKCA RGD RGD:3395
Canis familiaris PRKCA VGNC VGNC:44978
Others PRKCA NCBI