2. Gene
  3. DNPH1 - 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 Gene

DNPH1 - 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：2'-脱氧核苷 5'-磷酸 N-水解酶 1

种属: Homo sapiens

同用名: RCL; C6orf108; dJ330M21.3

基因 ID: 10591 | 基因类型: protein coding

关于 DNPH1

Cytogenetic location: 6p21.1 Genomic coordinates (GRCh38): 6:43,225,629-43,229,481 (from NCBI)

This gene has 4 transcripts (splice variants) and 163 orthologues. Broad expression in kidney (RPKM 65.7), duodenum (RPKM 28.6) and 23 other tissues.

功能概要

该基因是根据其受 c-Myc 蛋白的刺激而鉴定的。后者是参与细胞增殖、分化和凋亡调控的转录因子。该基因的确切功能尚不清楚，但对大鼠的研究表明它在细胞增殖和 c-Myc 介导的转化中发挥作用。已经描述了编码不同蛋白质的两种替代转录本。[RefSeq 提供，2008 年 7 月]

This gene was identified on the basis of its stimulation by c-Myc protein. The latter is a transcription factor that participates in the regulation of cell proliferation, differentiation, and Apoptosis. The exact function of this gene is not known but studies in rat suggest a role in cellular proliferation and c-Myc-mediated transformation. Two alternative transcripts encoding different proteins have been described. [provided by RefSeq, Jul 2008]

DNPH1 基因产物(2)

mRNA Protein Name
NM_006443.3 NP_006434.1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 isoform 1
NM_199184.2 NP_954653.1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables deoxyribonucleoside 5'-monophosphate N-glycosidase activity IDA
IDA: 通过直接分析推断
25108359 GOA
enables identical protein binding IPI
IPI: 通过物理相互作用推断
16189514 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
21044950 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in deoxyribonucleoside monophosphate catabolic process IDA
IDA: 通过直接分析推断
25108359 GOA
involved in epithelial cell differentiation IEP
IEP: 通过表达模式推断
21492153 GOA
involved in nucleoside salvage IMP
IMP: 通过突变表型推断
33833118 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
18726892 GOA
located in nucleus IDA
IDA: 通过直接分析推断
9271375 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

DNPH1 蛋白结构

Nuc_deoxyrib_tr

Nuc_deoxyrib_tr: Nucleoside 2-deoxyribosyltransferase (23 - 120)

  • 0
  • 100
  • 174 a.a.
蛋白主名 其他名称

2'-deoxynucleoside 5'-phosphate N-hydrolase 1

c-Myc-responsive protein RCL

DNPH1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
DNPH1 O43598 YWHAG Homo sapiens P61981
Validated Y2H
32814053
种属内
DNPH1 O43598 YWHAG Homo sapiens P61981
Y2H Array
32814053
种属内
DNPH1 O43598 YWHAG Homo sapiens P61981
Y2H Pooling
32814053
种属内
DNPH1 O43598 TERF1 Homo sapiens P54274
Pull Down
21044950
种属内
DNPH1 O43598 DDIT4L Homo sapiens Q96D03
Y2H Array
32296183
种属内
DNPH1 O43598 DDIT4L Homo sapiens Q96D03
Y2H Prey Pooling
32296183
种属内
DNPH1 O43598 DDIT4L Homo sapiens Q96D03
Validated Y2H
32296183
种属内
DNPH1 O43598 DNPH1 Homo sapiens O43598
Y2H Array
32296183
种属内
DNPH1 O43598 DNPH1 Homo sapiens O43598
Y2H Pooling
16189514
种属内
DNPH1 O43598 SETDB1 Homo sapiens Q15047-2
Validated Y2H
32814053
种属内
DNPH1 O43598 SETDB1 Homo sapiens Q15047-2
Y2H Pooling
32814053
种属内
DNPH1 O43598 SETDB1 Homo sapiens Q15047-2
Y2H Array
32814053
种属内
DNPH1 O43598 DNPH1 Homo sapiens O43598
Y2H Prey Pooling
32296183
种属内
DNPH1 O43598 DNPH1 Homo sapiens O43598
Validated Y2H
32296183
种属内
DNPH1 O43598 DNPH1 Homo sapiens O43598
Y2H Array
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Cardiomyopathy, Familial Restrictive, 1

RCM1

Restrictive Cardiomyopathy 1

Rcm

Familial Restrictive Cardiomyopathy 1

Cardiomyopathy, Familial Restrictive 1

Cardiomyopathy, Restrictive, Familial, Type 1

Rcm-1
Hypotrichosis 2

HYPT2

Hypotrichosis Simplex Of The Scalp 1

Htss1

Htss

Hypotrichosis, Spanish Type

Spanish Type Hypotrichosis

Hypotrichosis Spanish Type

Hypotrichosis, Type 2

Hypotrichosis Simplex Of Scalp
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS03915 DNPH1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus DNPH1 RGD RGD:620382
Felis catus DNPH1 VGNC VGNC:82473
Bos taurus DNPH1 VGNC VGNC:28149
Macaca mulatta DNPH1 VGNC VGNC:71877
Mus musculus DNPH1 MGD MGI:3039376
Canis familiaris DNPH1 VGNC VGNC:57238
Others DNPH1 NCBI
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