2. Gene
  3. HOXB13 - homeobox B13 Gene

HOXB13 - homeobox B13 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：同源框 B13

种属: Homo sapiens

同用名: HPC9; PSGD

基因 ID: 10481 | 基因类型: protein coding

关于 HOXB13

Cytogenetic location: 17q21.32 Genomic coordinates (GRCh38): 17:48,724,763-48,728,750 (from NCBI)

This gene has 1 transcript (splice variant), 194 orthologues, 42 paralogues and is associated with 2 phenotypes. Biased expression in prostate (RPKM 57.5) and colon (RPKM 27.9).

功能概要

该基因编码属于同源盒基因家族的转录因子。该家族的基因在脊椎动物中高度保守，对脊椎动物胚胎发育至关重要。该基因被认为在胎儿皮肤发育和皮肤再生中发挥作用。在小鼠中，一个相似的基因被证明在胚胎的主体轴上表现出时间和空间共线性，但在次轴上没有表达，这表明在沿着轴的身体模式中起作用。该基因与其他 HOXB 基因在染色体 17q21-22 区域形成一个基因簇。[RefSeq 提供，2008 年 7 月]

This gene encodes a transcription factor that belongs to the homeobox gene family. Genes of this family are highly conserved among vertebrates and essential for vertebrate embryonic development. This gene has been implicated to play a role in fetal skin development and cutaneous regeneration. In mice, a similar gene was shown to exhibit temporal and spatial colinearity in the main body axis of the embryo, but was not expressed in the secondary axes, which suggests functions in body patterning along the axis. This gene and Other HOXB genes form a gene cluster at chromosome the 17q21-22 region. [provided by RefSeq, Jul 2008]

HOXB13 基因产物(1)

mRNA Protein Name
NM_006361.6 NP_006352.2 homeobox protein Hox-B13
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
IDA: 通过直接分析推断
15126340 GOA
enables methyl-CpG binding IDA
IDA: 通过直接分析推断
28473536 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
32814053 GOA
enables sequence-specific DNA binding IDA
IDA: 通过直接分析推断
23332764 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: 通过直接分析推断
28473536 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in angiogenesis IEP
IEP: 通过表达模式推断
17972163 GOA
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
15126340 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

HOXB13 蛋白结构

HoxA13_N

HoxA13_N: Hox protein A13 N terminal (21 - 123)

Homeobox

Homeobox: Homeobox domain (217 - 273)

  • 0
  • 100
  • 200
  • 284 a.a.
蛋白主名 其他名称

homeobox protein Hox-B13

HOXB13 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
HOXB13 Q92826 YWHAG Homo sapiens P61981
Validated Y2H
32814053
种属内
HOXB13 Q92826 YWHAG Homo sapiens P61981
Y2H Array
32814053
种属内
HOXB13 Q92826 YWHAG Homo sapiens P61981
Y2H Pooling
32814053
种属内
HOXB13 Q92826 SETDB1 Homo sapiens Q15047-2
Y2H Pooling
32814053
种属内
HOXB13 Q92826 SETDB1 Homo sapiens Q15047-2
Validated Y2H
32814053
种属内
HOXB13 Q92826 SETDB1 Homo sapiens Q15047-2
Y2H Array
32814053
种属间: 跨种属相互作用 种属内: 同种属相互作用

HOXB13 抗体

目录号 产品名 应用 反应物种
HY-P81453 HOXB13 Antibody (YA1198) IHC-P Human

关联疾病

疾病名称 别名
Prostate Cancer, Hereditary, 9

HPC9

Cancer, Prostate, Hereditary, Type 9
Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer
Small Cell Carcinoma

Small Cell Carcinoma, Intermediate Cell

Intermediate Cell Small Cell Carcinoma

Small Cell Carcinoma - Intermediate Cell

Small Cell Carcinoma Of Lung

Carcinoma, Small Cell
Pancreatic Cancer

Pancreatic Carcinoma

Carcinoma Of Pancreas

Familial Pancreatic Carcinoma

Pancreatic Neoplasm

Pancreatic Carcinoma, Familial

Malignant Neoplasm Of Pancreas

Pancreatic Acinar Carcinoma

Pancreatic Tumor

Familial Pancreatic Cancer

Neoplasm Of The Pancreas

Cancer Of The Pancreas

Pancreatic Carcinoma, Somatic

Pancreatic Cancer, Somatic

Ca Body Of Pancreas

Ca Head Of Pancreas

Ca Tail Of Pancreas

Malignant Neoplasm Of Body Of Pancreas

Malignant Neoplasm Of Head Of Pancreas

Malignant Neoplasm Of Tail Of Pancreas

Pancreas Neoplasm

Exocrine Cancer

Exocrine Pancreas Carcinoma

Hereditary Pancreatic Cancer

Hereditary Pancreatic Carcinoma

PNCA

Pancreatic Cancer, Susceptibility To

Carcinoma Of Head Of Pancreas

Pancreatic Neoplasms

Pancreatic Tumors

Cancer, Pancreatic

Cancer Of Pancreas

Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Inflammatory Bowel Disease 2

IBD2
Spinal Cord Ependymoma

Ependymal Neoplasm Of The Spinal Cord

Spinal Ependymoma

Ependymoma Of Spinal Cord
Myxopapillary Ependymoma

Ependymoma Myxopapillary
Preaxial Deficiency, Postaxial Polydactyly, And Hypospadias

Guttmacher Syndrome

Preaxial Deficiency, Postaxial Polydactyly And Hypospadias

Autosomal Dominant Preaxial Deficiency, Postaxial Polydactyly, And Hypospadias

Preaxial Deficiency-Postaxial Polydactyly-Hypospadias Syndrome

GUTTS
Basal Cell Carcinoma

Basal Cell Cancer

Basal Cell Neoplasm

Basal Cell Carcinoma Of Skin

Malignant Basal Cell Tumor

Basal Cell Tumor

Epithelioma Basal Cell

Malignant Basal Cell Neoplasm

Rodent Ulcer

Carcinoma Basal Cell

Neoplasms, Basal Cell

Basal Cell Carcinomas

Experimental Organism Basal Cell Carcinoma

Nodulo-Ulcerative Basal Cell Carcinoma

Basalioma

Basal Cell Epithelioma Of Skin

Bcc - [Basal Cell Carcinoma] Of Skin

Rodent Ulcer Of Skin

Rodent Ulcer Of Unspecified Site

Basal Cell Epithelioma Of Unspecified Site
Lynch Syndrome

Hereditary Nonpolyposis Colon Cancer

Hereditary Nonpolyposis Colorectal Cancer

Hereditary Nonpolyposis Colorectal Carcinoma

Hereditary Nonpolyposis Colorectal Neoplasms

Familial Nonpolyposis Colon Cancer

Hnpcc

Coca 1

Hereditary Defective Mismatch Repair Syndrome

Hereditary Non-Polyposis Colon Cancer

Hereditary Non-Polyposis Colon Cancer Syndrome

Hereditary Non-Polyposis Colorectal Cancer

Hereditary Non-Polyposis Colorectal Cancer Syndrome

Hereditary Nonpolyposis Colon Cancer Syndrome

Hereditary Nonpolyposis Colorectal Cancer Syndrome

Hereditary Nonpolyposis Colorectal Neoplasm

Hnpcc - Hereditary Nonpolyposis Colon Cancer

Cancer Family Syndrome

Familial Nonpolyposis Colorectal Cancer

Colon Cancer, Familial Nonpolyposis

Colorectal Neoplasms, Hereditary Nonpolyposis

Cancer, Colorectal, Nonpolyposis, Hereditary

Colorectal Cancer, Hereditary Nonpolyposis, Type 1
Hereditary Breast Ovarian Cancer Syndrome

Hereditary Breast And Ovarian Cancer Syndrome

Brca1- And Brca2-Associated Hereditary Breast And Ovarian Cancer

Breast And/Or Ovarian Cancer

Breast And Ovarian Cancer Syndrome

Hboc Syndrome

Hereditary Breast And Ovarian Cancer

Brca1- Brca2-Associated Hboc
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-125051 SG3-179 Inhibitor / 否
HY-RS06305 HOXB13 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus HOXB13 VGNC VGNC:67622
Macaca mulatta HOXB13 VGNC VGNC:104617
Rattus norvegicus HOXB13 RGD RGD:1309113
Canis familiaris HOXB13 VGNC VGNC:41750
Bos taurus HOXB13 VGNC VGNC:29917
Mus musculus HOXB13 MGD MGI:107730
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z